Although nervous system complications often appear in hemolytic uremic syndrome (HUS), the relationship between HUS and the nervous system is still not clear. We suspect that damage to the nervous system may play a role in the pathophysiology of HUS. In this context, rats received different doses of lipopolysaccharide (LPS) or saline to celiac ganglia or peritoneum. In rats treated with LPS on the celiac ganglia, a significant decrease in platelet count (p < 0.05) and a significant increase in blood urea nitrogen (p < 0.05) were found, and at the same time plasma levels of adrenaline and noradrenaline increased markedly (p < 0.05). The renal arterioles and glomeruli showed endothelial swelling and narrowing of the lumina. Intense immunostaining for von Willebrand factor and fibrinogen in glomeruli and renal vessels was also observed. These parameters were accompanied by a systolic blood pressure elevation. The results suggest that the sympathetic nervous system plays an important role in the pathogenesis of HUS.

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PubMedDate not supplied

Systemic effects of the occlusal destruction in guinea pigs.

Although there is an increasing amount of information pertaining to the systemic effects of malocclusion, its mechanisms still remain unclear in many ways. This study was conducted to find out the systemic effects of the occlusal destruction in guinea pigs. The animals showed an abnormality in posture and a reversal of the T wave in electrocardiogram (ECG) about 6 days after the grinding of all molar teeth. All the animals died about 7 days after the occlusal destruction. We established the optimal condition of occlusal destruction for the induction of the above symptoms in guinea pigs: at least 6 molars, both side premolar, 1st and 2nd molar of upper jaw, because of the ease for repair. The following results were obtained: 1. The experimental group died about 5 days earlier than the fasting group. 2. The animals could not hold their head positions and dropped the head to the earth. 3. The animals died about 12 hours after the onset of postural abnormality. 4. Ninety percent of the animals with postural abnormalities showed T wave inversion on ECG. 5. None of the above symptoms occurred with bite rising. These results indicate that occlusal destruction affects head position, preventing the animals to hold their head positions and causing the head to drop to the ground. Occlusal destruction may also cause abnormality of the masticatory muscles, which control posture and modulate cardiac function via the trigeminal system. This experimental model is suitable for the analysis of the systemic effects of occlusal destruction.

Animals↗