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Biomedical subjects

K Müller

Publications and source records attributed to K Müller.

At least 343 records · Page 19Linked to original sources
PubMed1986

[Dextran 40 or HES 200/0.5? Hemorheology of the long-term treatment of ischemic cerebral attacks].

Haemorheological parameters on long-term treatment of ischaemic stroke were measured in two groups of 12 patients receiving dextran 40 or hydroxyethyl starch (HES 200). Both substances similarly lowered haematocrit and whole-blood viscosity. Dextran produced a clear-cut increase in plasma viscosity and red-cell aggregation. The effects were due to a marked increase in the plasma concentration of dextran caused by an accumulation of large molecules. HES 200 improved plasma viscosity and red-cell aggregation. Since these haemorheological parameters are of special importance for improving a disordered microcirculation as would occur at the margins of the ischaemic lesion, HES 200 would seem to be the appropriate plasma expander in long-term treatment with haemodilution. The differences between dextran 40 and HES 200 become the more marked the higher the volume infused.

Blood Viscosity↗
PubMed1986

Influence of insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) on influenza virus multiplication.

Insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) interfere with the multiplication of fowl plague virus, an influenza A virus, in primary chick embryo cells. Specifically the production of the viral glycoproteins hemagglutinin and neuraminidase are affected by the drugs. A decrease or omission of glucose from the culture medium enhances this effect, which is in agreement with the idea that these drugs act on virus replication via a shortage of glucose in the host cell. Virus replication in cells of different organs is affected to different extents by insulin and TPA.

Animals↗
PubMed1986

Mast cell sarcoma of the larynx.

A 74 year old woman presented with a primary subglottic tumour. Neither cutaneous mastocytosis (urticaria pigmentosa) nor spread to the bone marrow, liver, or spleen were detected. About two years after initial manifestation of the tumour nodular skin metastases appeared, as well as local recurrence in the larynx. Despite chemotherapy and radiation the disease progressed and was fatal. The terminal phase was characterised by generalisation of the mast cell tumour with diffuse infiltration of bone marrow and, shortly before death, leukaemic transformation. The patient died four years after onset of disease with symptoms of a hemorrhagic diathesis. As far as we know this is the first case of mast cell sarcoma to be reported in man.

Aged↗
PubMed1986

[Effect of the delivery procedure on perinatal mortality and neonatal morbidity of underweight infants in the breech position].

The paper deals with the effect of the delivery technique used on perinatal mortality and neonatal morbidity rates. Overall mortality of 236 underweight breech babies (less than 2,500 g) and a number of morbidity parameters of 68 new-born children of 1,000 to 2,000 g birth weight are studied collected over a period of comparable perinatological management. The results show that cesarean section is the most favourable technique for children of 1,000 to 2,000 g birth weight. To do so, it is necessary to exclude non-viable malformations prenatally and to ensure a reliable neonatological intensive care. Another major problem is to prevent premature birth. On the basis of the results obtained and taking into account anamnestic and obstetrical risks, we give preference to an adequate selective section to deliver underweight children from breech presentation, but do not rule out vaginal methods of delivery using good techniques and proceeding as carefully as possible.

Birth Weight↗
PubMed1986

[1,000 pancreolauryl tests: evaluation of sensitivity, specificity and use in clinical routine].

1115 examinations with the Pancreolauryl-Test (PLT) were carried out and assessed on 918 non-selected patients with various gastro-enterologic diseases. Depending on the severity of the exocrine insufficiency, sensitivity varied in confirmed chronic pancreatitis (n = 54). Overall sensitivity was 69%, in chronic pancreatitis with steatorrhoe 100%, and 54% in moderate insufficiency. In all patients not suffering from pancreatic diseases (n = 789) specificity was 77%. Since the PLT was frequently pathological in patients with subtotal gastrectomy (gastric resection) and active peptic lesion, specificity was also determined excluding these cases (29% of all patients without pancreatic disease). This resulted in a specificity of 86%. Gastric hyperacidity should be taken into consideration as a possible source of errors (for example, in the condition following an ulcer). Age, weight and alcohol consumption as well as diseases of the bile duct and liver, had no influence on specificity. Urine collection errors, occurring in 10% of the patients investigated, could be avoided by determination of fluorescein in the serum. Our results from a series of examinations on non-selected patients with a 6% prevalence of chronic pancreatitis indicated that PLT is likely to increase predictive value in selected application. If the oesophagus-gastro-duodenoscopy is non-pathological but the PLT gives a pathological result, further pancreatic investigative procedures should be carried out.

Adult↗
PubMed1986

Lesions in the mesencephalic part of pedunculopontine nuclei modify goal-directed behaviour.

Eleven Long-Evans hooded rats were preoperatively tested in an open field (OF), then trained in a Y-maze and thereafter symmetrically lesioned in the mesencephalic part of the pedunculopontine nuclei (MPPN). The OF test on the 11th postoperative day revealed no significant changes in exploratory behaviour, but a significant increase of ambulatory activity during all periods of 10 min exposure. This points to the role of the lesioned structure in response inhibition and habituation. High postoperative retention of preoperatively learnt conditioned avoidance responses (CAR) and of brightness discrimination showed no memory deficit. Reaction times were significantly decreased in the MPPN rats without symptoms of enhanced emotional activation. The escape speed from start to goal box was significantly slowed down after lesion. The formation of a new CAR stereotype in the jump test was impossible after MPPN lesions, because the rats did not find the escape possibility. The results differ from that of other mesencephalic reticular lesions.

Animals↗
PubMed1985

Reversion of bovine papillomavirus-induced transformation and immortalization by a xanthate compound.

Bovine papilloma virus-transformed hamster embryo fibroblasts (HEF-BPV) reacted to exposure to tricyclodecan-9-yl-xanthogenate (D609) with immediate reversion to the growth kinetics and the flat morphology of the untransformed parental cells. After six population doublings in the presence of D609, clones which displayed an untransformed morphology in the absence of D609 arose with a high frequency (90%). Such clones had reacquired a limited in vitro lifetime and had lost the ability to induce tumors in athymic nude mice. At the molecular level the revertant clones had lost all extrachromosomal monomeric BPV-1 DNA molecules. Only high molecular weight (HMW) oligomeric BPV-1 DNA that was probably integrated into the cellular genome was still detectable in a methylated transcriptionally inactive state. In contrast to transformed cells, the revertant clones no longer transcribed BPV-1-specific mRNA molecules, but were stimulated by a tumor promoter to transient viral gene expression. This article provides direct evidence for the complete reversibility of the property of "immortality".

Animals↗
PubMed1985

[Esophageal carcinoma: surgery using transhiatal esophagectomy without thoracotomy].

During the period between 1982 and 1984, 25 patients with carcinoma of the esophagus underwent esophageal resection by the technique of blunt transhiatal esophagectomy without thoracotomy. The esophagus was replaced with stomach. The indications for blunt dissection of the esophagus are discussed and the operative technique is described. There was no postoperative mortality. Complications included pulmonary complications (19), anastomotic leak (9), left vocal cord paralysis (5) and stenosis of the cervical anastomosis (7). Postoperative hospitalization averaged 18 days. Following discharge from hospital patients are seen in follow-ups at 3-month intervals for 1 year, then at 6-month intervals. Quality of life is good. In the majority of patients with esophageal carcinoma, the goal of esophagectomy is palliation, not cure. Therefore, long-term prognosis of esophageal carcinoma is poor. Actual survival among the patients is 49% at 12 months, and mean survival 10.2 months. Transhiatal esophagectomy without thoracotomy is a safe procedure and far better tolerated by elderly and debilitated patients than a combined transthoracic and abdominal operation. We believe that this procedure is the treatment of choice for esophageal carcinoma at all levels.

Aged↗