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Biomedical subjects

K M Smith

Publications and source records attributed to K M Smith.

At least 235 records · Page 13Linked to original sources
PubMed1967

Intracellular inclusions in the gut epithelial cells of Piesma cinereum Say.

Intracellular inclusions in the epithelial cells of the midgut of Piesma cinereum (Hemiptera) are described. Three types of inclusions have been observed in both viruliferous and "virus-free" insects. Two of them, alpha and beta, are free in the cytoplasm and are of two different basic configurations: one exhibits bilateral symmetry, the other a fivefold radial symmetry. Still another type of inclusion is contained in membrane-bounded bodies and consists of elongate, irregularly shaped crystals. A description of the structure of the inclusions is given and their nature and significance are discussed.

Animals↗
PubMedDate not supplied

Comparative in vivo sensitizing efficacy of porphyrin and chlorin dimers joined with ester, ether, carbon-carbon or amide bonds.

The anti-cancer activity of dimers joined with ether, ester or carbon-carbon bonds by photodynamic therapy (PDT) was compared by using DBA/2 mice transplanted with SMT/F tumors. Dimers with ether and carbon-carbon linkages were found to be more effective than those linked with ester bonds. Variation of the substituents at peripheral positions made a significant difference in in vivo efficacy. Among the ether and carbon-carbon linked dimers, the divinyl analogs were found to be most effective. The preliminary in vivo results also suggest that the position(s) of the hydrophilic substituents in the molecules make a remarkable difference in photosensitizing activity. An unsymmetrical dimer with an amide linkage, obtained from 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) was found to be less effective than HPPH.

Amides↗
PubMedDate not supplied

Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris.

Prunellin, an anti-HIV active compound, was isolated from aqueous extracts of the Chinese medicinal herb, Prunella vulgaris, and purified to chromatographic homogeneity. Infrared and NMR spectroscopy identified prunellin as a polysaccharide. Elemental analyses, precipitation with calcium(II), barium(II), or 9-aminoacridine suggest a sulfated polysaccharide. Paper chromatography of the exhaustively hydrolyzed material indicates the presence of glucose, galactose, xylose, gluconic acid, galactonic acid and galactosamine as the constituent monosaccharides. The molecular size of prunellin, as determined by gel permeation chromatography and the Squire method on Sephadex G-75, is about 10 kDa.

Antiviral Agents↗
PubMedDate not supplied

The innocent heart murmur in children.

Most children have an audible murmur at some point from infancy through adolescence. Fortunately most of these murmurs are innocent. These murmurs are asymptomatic and require no follow-up care. On the other hand, pathologic murmurs are symptomatic and do require assessment by a pediatric cardiologist. Referrals are not only anxiety-provoking for the family but are also costly. The pediatric nurse practitioner must therefore be able to differentiate between the innocent and pathologic murmur. Auscultation of heart sounds is the most effective method used to assess murmurs. Given that innocent murmurs are asymptomatic, they require minimal follow-up care, and the expected outcome for a child with the diagnosis of such a murmur is excellent.

Adolescent↗