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Biomedical subjects

K M Peters

Publications and source records attributed to K M Peters.

50 records · Page 3Linked to original sources
PubMed1989

The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat.

To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet-induced fibrosis, rats were fed a control or cirrhogenic diet for 6 months and treated with either subcutaneous vehicle or the hepatoprotective prostaglandin 16,16-dimethyl prostaglandin E2 (100 micrograms per kg) twice daily. Pair-fed rats from each group were killed after 2, 4 or 6 months. The value of serum procollagen type III peptide to body weight integrated over time (Kt) correlated linearly with hepatic hydroxyproline content (r = 0.97) at killing time t. Good correlations were also seen between Kt and histopathological assessment of aniline blue-stainable collagen (r = 0.93) and between the histopathology and hydroxyproline content (r = 0.97). Rats receiving 16,16-dimethyl prostaglandin E2 had lower values of all three parameters compared to rats receiving vehicle, confirming the previously demonstrated hepatoprotective effect of 16,16-dimethyl prostaglandin E2. The excellent correlation between Kt and the two other traditional parameters of hepatic collagen suggest that sequential measurements of serum procollagen type III peptide can be used to predict alterations in liver collagen deposition in rats.

16,16-Dimethylprostaglandin E2↗
PubMed1989

16,16 Dimethyl prostaglandin E2 decreases the formation of collagen in fibrotic rat liver slices.

The effect of 16,16 dimethyl prostaglandin E2 (DMPG) on fibrogenesis was studied in slices from normal and fibrotic rat liver. Rats received a cirrhogenic diet for seven months; supplemented controls received a diet with the deficient nutrients restored. Slices from fibrotic livers incorporated more 14C-proline and produced more 14C-hydroxyproline in TCA precipitable proteins than slices from control livers. DMPG (10(-10) M) decreased the incorporation of labeled proline and the synthesis of labeled hydroxyproline in slices from fibrotic livers to the same extent, suggesting that DMPG did not affect the hydroxylation of proline per se. The magnitude of the DMPG induced decrease in labeled proline incorporation correlated with the hydroxyproline content in the liver (i.e. with increasing fibrosis there was a greater effect of DMPG: while in control rat liver slices, DMPG had no effect). DMPG did not change the size of the proline pool, its specific activity, or the activity of proline oxidase. We conclude that under these conditions of enhanced fibrogenesis, DMPG decreases the formation of collagen in vitro, possibly by lowering the incorporation of proline into collagen precursors. This may explain, at least in part, the inhibition of fibrogenesis by DMPG in vivo.

Animals↗
PubMed1989

[The value of tumor markers in colorectal cancer].

In 137 patients with colorectal carcinoma carcinoembryonic antigen (CEA) was preoperatively measured in serum. Sensitivity of CEA was dependant on the tumor stage. Patients in early tumor stages (TNM stages I + II) demonstrated only in 10% grossly elevated CEA levels compared with 43% of patients with progressive tumor stages (TNM III + IV). The main importance of tumor markers lies still in postoperative follow-up. In patients with a local recurrence of colorectal carcinoma we measured in 57% CEA levels greater than 10ng/ml, in patients with distant metastases even in 75%. CA 19-9 achieved a lower sensitivity in postoperative follow-up of colorectal carcinoma than CEA. Only 22% of patients with a recurrence of colorectal carcinoma had CA 19-9 levels beyond the normal range (37 U/ml) compared with 67% elevated CEA levels in the same group of patients. CEA is still the most important tumor marker in colorectal carcinoma. Measurement of CA 19-9 in postoperative follow-up is no substitute for CEA, it can only be a supplement.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1988

[Threatening preoperative conditions in hyperparathyroidism].

Within 10 years in 2 out of 44 patients with pHPT (4.5%) a hypercalcemic crisis, in 3 other patients symptoms of hypercalcemic syndrome were observed. A quick diagnosis of the life threatening situation and a therapy of decreasing calcium led to an elective operation.

Aged↗
PubMed1988

[Fiber in the diet--certainties and speculation].

This report defines dietary fibre and summarizes its effects on dental, gastrointestinal and metabolic diseases. A higher intake of dietary fibre is important in prophylaxis of caries, paradentosis, constipation, diverticulosis, colon cancer, diabetes and hypercholesteraemia. An ideal preparation must have the following abilities: It should be coarse, hard and swallowable and without cariogenic sugars in order to prevent dental diseases. It should be a mixture of several kinds of fibre getting water binding capacity and bile acid binding capacity. Mechanical crushing and heatening of fibre are to be avoided. The preparation should not contain phytic acid.

Colonic Neoplasms↗
PubMed1987

[The effect of cephalexin on thrombocyte function in diabetics and normal persons].

Studies on the Effect of Cephalexin on Platelet Functions in Diabetics and Healthy Volunteers. The effect of cephalexin (Ceporexin) on platelet functions of diabetics with proliferative retinopathy and of healthy volunteers was studied. Cephalexin, 3 X 1 g for 7 days, reduced epinephrine- and collagen-induced platelet aggregation of the diabetics in a significant, but clinically not relevant manner. Platelet factor-3 availability and retraction remained unaffected by treatment with cephalexin. Cephalexin in vitro in a concentration of 500 mg/l reduced the rate and peak amplitude of platelet aggregation in diabetics and healthy volunteers to the same extent. The in vitro inhibition of epinephrine- and collagen-induced platelet aggregation was lacking clinical relevance. Platelet factor-3 availability was not changed by addition of cephalexin in vitro; the retraction was significantly increased, however, without clinical relevance.

Adult↗
PubMedDate not supplied

16,16-Dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver.

Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E2 on the deposition of collagen and fat was assessed by histological evaluation and measurement of hydroxyproline. Dose-response studies established that optimal protection was achieved by the twice daily administration of 16,16-dimethyl prostaglandin E2 at 100 micrograms per kg (subcutaneous) or 250 micrograms per kg (oral). 16,16-Dimethyl prostaglandin E2 and a crystalline analog [(p-acetamidobenzamido)phenyl ester of 16,16-dimethyl prostaglandin E2 significantly delayed both the deposition of collagen and the increase in hepatic hydroxyproline content. There was an excellent correlation between the histological assessment of collagen and the biochemical measurement of hydroxyproline. These data provide a rationale for the evaluation of prostaglandins in the treatment of human liver disease.

16,16-Dimethylprostaglandin E2↗
PubMedDate not supplied

[Functional and socioeconomic outcome of inpatient rehabilitation of patients with complex hand injuries].

PURPOSE: Evaluation of functional outcome and socio-economic results of patients with complex hand injuries after inpatient rehabilitation. PATIENTS AND METHODS: In a prospective investigation 36 patients with complex hand injuries received an intensive therapy regime under inpatient conditions. In all patients functional parameters of the hand (total active range of motion, palm to palm distance, spread between thumb and index finger, spread between thumb and little finger) and the score of Buck-Gramcko were registered initially and at the end of inpatient rehabilitation. Socio-economic data (kind of discharge, job reintegration, further treatment) were documented as well. RESULTS: The total active range of motion could be improved from 36% to 69%, spread D1-D5 from 18.5 to 20.7 cm and spread D1-D2 from 13.9 to 15.6 cm. The palp to palm distance of all fingers was reduced from 4.6 cm to 2.3 cm. The Buck-Gramcko score of all injured fingers improved from 4.2 points (poor) at admission, to 11.8 points (good) at discharge, At the end of inpatient rehabilitation 18 patients could return to their job either gradually or on full-time. CONCLUSION: Even patients with complex hand injuries, good functional results could be achieved by an intensive inpatient rehabilitation characterised by close medical supervision and guidance and tight clinical controls.

Adult↗
PubMedDate not supplied

[Neopterin determination in the screening for spongiosa donors].

HIV-1 and HIV-2 antibodies, erythrocyte sedimentation rate, leucocytes and additionally serum neopterin levels were measured in 100 potential spongiosa donors. HIV antibodies were negative in all patients, whereas in 24% neopterin levels were elevated (greater than 10 nmol/l). Enhanced neopterin production is related to activity in cell-mediated immune response. In further investigations of these patients we found in 29% infections, 38% tumor diseases and 13% autoimmune diseases, all being exclusion criteria for spongiosa transplantation. In 3 patients increased neopterin values were the only pathological screening parameters. The measurement of serum neopterin levels showed to be a helpful parameter for the selection of spongiosa donors.

Aged↗
PubMedDate not supplied

[Suppression of macrophage subpopulations in post-traumatic osteomyelitis].

Similar to other chronic inflammatory diseases such as rheumatoid arthritis the distribution of macrophage subtypes seems to be disturbed in post-traumatic osteomyelitis. This atypical distribution is clearly locally restricted in osteomyelitis. 27E10-positive macrophages found only during the acute phase of inflammation were reduced in 39%, the 25F9-positive subtype, predominating in the late stage of inflammation, was missing in 33%. The antiinflammatory macrophage RM3/1 was decreased in 40% of the osteomyelitis biopsies. Local suppression of macrophage subsets has to be discussed as one of the reasons for the persistence of chronic inflammatory processes in osteomyelitis.

Adolescent↗
PubMedDate not supplied

[Immune reactions in chronic post-traumatic osteomyelitis. Current status determination].

Investigations in patients with chronic post-traumatic osteomyelitis could demonstrate several deficits in immunologic response: Phagocytic activity of phagocytes is lowered accompanied by a functional deminution of leukocyte receptors for C3. Intracellular killing is diminished. Investigations concerning T lymphocyte subpopulations verified a decrease in total T cells and helper/inducer T cells. Dysfunctions in specific humoral immune response are still debatable.

Antibody Formation↗