A case of West Nile (WN) virus encephalitis.
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Biomedical subjects
Publications and source records attributed to K M Pavri.
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Acute-phase stool samples collected from hepatitis cases during outbreaks of water-borne epidemic hepatitis were examined by immune electron microscopy (IEM). Spherical virus-like particles (27 nm in diameter) were visualized in the stool of a hepatitis patient with serological evidence of non-A, non-B (NANB) hepatitis. The IEM demonstrated serological specificity of the antigen with the patient's own convalescent serum as well as a known pool of NANB hepatitis convalescent sera. It is suggested that these virus-like particles may be the aetiological agent of faeco -orally transmitted NANB epidemic hepatitis in India.
The isolation of West Nile virus from the brain tissue of three children who died of encephalitis in Mysore and Kolar districts of Karnataka State, India, is reported. This is the first such report from India. The significance of these isolations with reference to the role of West Nile virus in encephalitis in children in southern India is discussed.
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During the course of continuous surveillance of influenza in 1980 in Pune, India, which has a tropical monsoon climate, three outbreaks of acute respiratory infection (ARI) were investigated in March (hot season), in July-September (rainy season), and in November (cold season); sporadic cases during the interepidemic months were also studied. The first outbreak was associated with influenza A virus (H3N2), the second with influenza A viruses (H3N2) and (H1N1) and influenza B virus, but fewer influenza viruses were isolated during the third outbreak. The illnesses affected all age groups including infants and adults over 60 years of age, although the paediatric age group was mainly affected. The ARI outbreaks associated with the hot and cold seasons commenced at about the time the weather changed whereas the mixed influenza A (H3N2) and A(H1N1) outbreaks occurred in the middle of the rainy season.
69 serum pairs from two common-source water-borne outbreaks and one series of endemic cases of hepatitis in three parts of India were tested for hepatitis A and hepatitis B virus infections. None of the patients had evidence of HAV infection and only 10.1% had evidence of HBV infection. A large proportion of hepatitis in India seems to be caused by previously unrecognised agents.
Significantly high levels of immunoglobulin E in the acute sera of encephalitis cases (suspected or confirmed as Japanese encephalitis) declined sharply during early convalescence.
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