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Biomedical subjects

K M Krishnamoorthy

Publications and source records attributed to K M Krishnamoorthy.

At least 37 records · Page 2Linked to original sources
PubMed2003

Prediction of atrial fibrillation in patients with severe mitral stenosis--role of atrial contribution to ventricular filling.

OBJECTIVE: Atrial contribution to ventricular filling was studied to assess its role in predicting the future development of atrial fibrillation (AF) in patients with severe mitral stenosis (MS) and sinus rhythm. DESIGN: Two hundred and eight patients with severe MS and sinus rhythm were followed up for 1 year. Baseline data were compared between group I (who developed AF at follow-up) and group II (who maintained sinus rhythm). Left atrial size, severity of MS, velocity time integral (VTI) of mitral valve flow and VTI due to atrial systole (A-VTI) were noted. Percentage contribution of A-VTI to the total VTI (A-%) was calculated. Sensitivity and specificity of A-% to predict the onset of AF was obtained. RESULTS: Left atrial size, severity of MS and total VTI were similar in the two groups. Group I patients were older (31.1 +/- 9.1 and 18.4 +/- 6.5 years, respectively, p < 0.03) with smaller A-VTI (5.3 +/- 2.2 and 6.7 +/- 3.4 cm, respectively, p < 0.01) and A-% (8.9 +/- 1.8 and 11.2 +/- 2.7, respectively, p < 0.003). A-% of <9% (mean value of A-VTI in group I) had high sensitivity (84%, positive predictive value 76%) and specificity (80%, negative predictive value 87%) to predict the development of AF. CONCLUSION: Atrial contribution to ventricular filling is reduced in patients prone to develop AF (due to inefficient left atrial contraction, much before its dilatation). It can be used for early identification of patients likely to develop AF with high sensitivity and specificity. It is simple, easily available, cost-effective and will guide earlier intervention and more frequent follow-up. There is a preclinical loss in atrial pump function much before the eventual onset of AF.

Adolescent↗
PubMed2002

Comparison of percutaneous transmitral commissurotomy with Inoue balloon technique and metallic commissurotomy: immediate and short-term follow-up results of a randomized study.

BACKGROUND: The Inoue balloon technique for mitral commissurotomy is well established and carried out worldwide. Metallic commissurotomy is reported to be a cheaper and effective alternative to balloon mitral commissurotomy. METHODS: One hundred patients were randomized into 2 groups to undergo percutaneous transmitral commissurotomy (PTMC) by means of the Inoue balloon technique (IBMC, n = 49) or metallic commissurotomy (PMMC, n = 51). Patients were crossed over to the other technique when the initial technique was a failure. Success of valvotomy, procedure-related complications, and follow-up events of the 2 techniques were compared. RESULTS: Basal echocardiographic and hemodynamic data were similar in both groups. Procedural success was similar in both groups: 45 of 49 procedures (91.8%) in the IBMC group, compared with 46 of 51 procedures (90.18%) in the PMMC group (P = 1.0). Crossover was also comparable, with 1 occurring in the IBMC group, compared with 3 in the PMMC group. Complications such as cardiac tamponade and mitral regurgitation (requiring or not requiring mitral valve replacement) were similar in both groups, with 3 complications in the IBMC group, compared with 4 complications in the PMMC group (P =.29). After a follow-up period of approximately 4 months, both groups had similar event rates and comparable hemodynamic parameters (P = not significant). CONCLUSIONS: Both IBMC and PMMC are successful means of providing relief from severe mitral stenosis with a gain in valve area and reduction in transmitral gradient. Both techniques have similar procedural success, complication rates, and follow-up events.

Adult↗
PubMed2001

Congenital bilateral aplasia of external iliac arteries.

A child with bilateral aplasia of external iliac arteries with normal internal iliac arteries, demonstrated by vascular Doppler and digital subtraction angiography is presented. Popliteal artery is reformed by collaterals. This anomaly is extremely rare.

Angiography, Digital Subtraction↗
PubMed2001

Pulmonary artery to left atrial fistula.

A patient with type I right pulmonary artery to left atrial fistula is being presented. He had cyanosis with no precordial findings. Diagnosis was made by transoesophageal echocardiography. Simple ligation of the fistula without cardiopulmonary bypass resulted in complete cure. Early operation to prevent complications is highlighted. Transoesophageal findings of the lesion have not been reported in literature.

Adult↗