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Biomedical subjects

K M Kim

Publications and source records attributed to K M Kim.

234 records · Page 13Linked to original sources
PubMed1976

Cellular pathophysiology of hepatitis.

This paper represents an analysis of the subcellular events that occur in the human liver in viral hepatitis. They involve both hepatocytes and sinusoidal lining cells, including Kupffer cells. We present a new hypothesis concerning the sequence of events that occurs in hepatic parenchymal cells. These events begin with a virus-hepatocyte interaction that involves primary damage to the cell membrane. This is assumed to trigger a complex sequence of events that results in the characteristic hepatocellular impairment of this disease. These events center around ionic shifts resulting from an altered plasma membrane, leading to interactive events in hepatocyte organelles, mostly reversible, but resulting in the characteristic hepatocellular impairment.

Bile Ducts↗
PubMed1975

Amorphous calcium precipitations in human aortic valve.

Spheroidal, granular, and fibrillar particles were observed in human aortic valve calcifications. Spheroids were similar to amorphous calcium phosphate shown previously in syn thetic preparations and in bone. The frequent coexistence of needle shaped hydroxyapatite crystals with granular and fibrillar particles suggests that the latter are also amorphous calcium phosphate and may be precursors of hydroxyapatite. All three types of particles had a tendency to form laminated and spherular secondary and failed to give a crystalline pattern by electron diffraction.

Aging↗
PubMedDate not supplied

Pedunculated exogastric leiomyoblastoma presenting as a wandering abdominal mass.

We report the imaging findings in a case of pedunculated exogastric leiomyoblastoma presenting as a wandering abdominal mass. Ultrasound and computed tomography showed a large, mixed solid and cystic mass in the peritoneal cavity. Computed tomography clearly showed that the mass was connected to the stomach by a narrow stalk. Small bowel follow-through showed subtle extrinsic indentation of the gastric body. The mass wandered from the right to the left side of the peritoneal cavity during various radiologic examinations.

Abdomen↗
PubMedDate not supplied

Depression in late life: age of onset as marker of a subtype.

Late-onset depression may be pathogenetically and prognostically distinct from early-onset, recurrent affective disorder. The authors reviewed records of 94 consecutively admitted unipolar major depressives over the age of 60 years, divided subjects into groups based on their age of onset, and examined demographic and clinical features. Late-onset elderly depressives had a lower incidence of family history of affective illness, longer hospital stay, and more residual symptoms at discharge. However, there was no demonstrable relationship between age of onset and presence of psychosis, melancholia, medical illness, symptom severity at admission, or indicators of neuropathology. Although late-onset elderly depressives did less well than those with early-onset illness, the data do not support the notion of late-onset depression as a distinct pathological process.

Adolescent↗
PubMedDate not supplied

Prediction of the development of atopic symptoms in early childhood by cord IgE-binding factors (soluble Fc epsilon R2).

The relationship of cord serum sFc epsilon R2 levels to the development of atopic symptoms in early childhood was studied. Cord sFc epsilon R2 was 444.2 +/- 235.1 pg/ml (n = 77), which was not significantly different from maternal serum sFc epsilon R2 (541.7 +/- 346.9 pg/ml, n = 42). However, there was no correlation between cord and maternal serum sFc epsilon R2, suggesting that most, if not all, of cord serum sFc epsilon R2 was produced by the fetus itself. Cord serum sFc epsilon R2 in infants who developed atopic symptoms later was significantly higher than that in infants who were free of atopic symptoms (P less than 0.01 at 7 and 13 months of age). The incidence of the development of atopic symptoms increased with the increase of cord serum sFc epsilon R2. These results suggest that sFc epsilon R2 is related to the development of atopic disorders and that the measurement of cord serum sFc epsilon R2 may be of value in predicting the development of atopic disorders in early childhood.

Antibodies, Monoclonal↗
PubMedDate not supplied

Adenoid cystic carcinoma of the maxillary antrum.

PURPOSE: To investigate characteristic clinical features and outcome for patients with adenoid cystic carcinoma (ACC) of the maxillary antrum. PATIENTS AND METHODS: Twenty-two patients with ACC of the maxillary antrum were initially treated with surgery alone (3 patients), radiation alone (9 patients), or a combination of surgery and radiation (10 patients). Salvage treatment for initial failure was individualized. Patterns of failure, survival, and prognostic factors were retrospectively analyzed. RESULTS: The most frequent site of failure was local recurrence at the primary site (72.7%). All patients treated with either surgery alone or radiation alone experienced one or more local recurrences, whereas patients who received planned combined surgery and radiation had a much lower local recurrence rate (40%). Neck node failure (4.6%) was an uncommon event, whereas distant metastases were clinically documented in seven patients (32%). Most of the treatment failures appeared within 5 years, but treatment failures after 5 years were not uncommon. The overall survival and disease-free survival rates at 10 years were 37.6% and 13.6%, respectively. Clinicopathological factors, such as location of primary tumor, tumor stage, and histological grade were of no value in predicting a favorable survival. The significant prognostic factors influencing 10-year survival were the pathological finding of perineural invasion and the initial mode of treatment. CONCLUSION: ACC of the maxillary antrum represented a unique natural history characterized by a more aggressive tumor behavior and an unfavorable prognosis. Combined surgery and radiotherapy is recommended for optimal local control and survival.

Adult↗
PubMedDate not supplied

Development of a method for measuring myocardial contractility with gated myocardial SPECT and arterial tonometry.

BACKGROUND: Gated myocardial single photon emission computed tomography (SPECT) and radial artery applanation tonometry were used, respectively, to quantify the time-volume curve of the left ventricle and to estimate ventricular pressure wave. We developed ways of determining end-systolic elastance (Ees) with the normalized-single-beat method and tested the reproducibility of these measurements. METHODS AND RESULTS: In patients with coronary artery disease (male/female = 33:2, age 66 +/- 10 years, ejection fraction 22% to 77%), rest thallium-201 gated/poststress technetium-99m sestamibi gated SPECT/24-hour rest Tc-99m sestamibi gated SPECT and arterial tonometry were performed. Quantitative gated SPECT software yielded a systolic time-volume curve, and tonometrically measured radial artery pressure wave yielded central aortic pressure wave. With systolic half of pressure-volume curve, void volume (Vo) was estimated and Ees was calculated. Over 71 measurements Ees ranged from 1.7 to 5.3 and Vo from -4 to 200 mL. Ejection duration, other indexes of central pressure waveform, end-diastolic volume, end-systolic volume, and ejection fraction were reproducible. The reproducibility of Vo was excellent (r = 0.97). Ees at rest (n = 15) showed fair reproducibility between Tc-99m-sestamibi and TI-201 SPECT (r = 0.51). CONCLUSION: With gated myocardial SPECT, a noninvasive method of quantifying myocardial global contractility was developed. Reproducibility of this measurement was sufficient for use in clinical routine. Ees measured by this method warrants validation by invasively measured Ees.

Aged↗
PubMedDate not supplied

Electrophilic substitution of (diamine)tetrahydroxoplatinum(IV) with carboxylic anhydrides. Synthesis and characterization of (diamine)platinum(IV) complexes of mixed carboxylates.

A novel series of (diamine)platinum(IV) complexes of mixed carboxylates have been synthesized by electrophilic substitution of the tetrahydroxoplatinum(IV) complex (dach)Pt(OH)4 (dach = trans-(+/-)-1,2-diaminocyclohexane) with three different carboxylic anhydrides, pivalic, acetic, and trifluoroacetic anhydrides. Consecutive two-step acylations with two different carboxylic anhydrides in acetone or dichloromethane gave the mixed carboxylate complexes (dach)Pt(O2CR)x(O2CR')4 - x (R = C(CH3)3 or CF3, R' = CH3, x = 1-4) including all the possible stereoisomers, which could be separated and identified by means of HPLC, column chromatography, 1H NMR, and X-ray crystallography. From analysis of the reaction products we have found that the positions of electrophilic substitution of (dach)Pt(OH)4 were influenced by the kinds of carboxylic anhydrides exhibiting different electrophilicity or steric effects. The initial substitution by the first reactant occurs more favorably on axial OH, but in the case of pivalic anhydride, equatorial substitution is favored probably because of the bulkiness of the pivalate group. Such a result seems to be related to their stereochemical factors rather than to differences in electrophilicity. The lipophilicity of the title complexes was affected not only by the carbon numbers of substituents but also by the conformation of the resulting compound.

Journal Article↗
PubMedDate not supplied

A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates.

The interaction of 4-1BB and its ligand plays an important role in the regulation of T-cell-mediated immune responses. In this study, the authors examined the effect of a humanized anti--4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB molecule, was generated and characterized. Based on this antibody, a humanized version of 4B4 monoclonal antibody was constructed and the resultant antibody, H4B4, showed full recovery of the binding activity of the original antibody 4B4: a 1.5-fold increase in affinity for 4-1BB. In addition, H4B4 mediated antibody-dependent cellular cytotoxicity of activated human peripheral blood T cells and CEM cells in a dose-dependent manner. Weekly administration of H4B4 at doses of 1 or 4 mg/kg could suppress immunoglobulin G production against ovalbumin. This was not a result of the overall immune suppression, because the numbers of B and T cells and the total immunoglobulin G production were not altered during treatment with H4B4. These findings suggest that treatment with H4B4 may be a valid therapeutic approach to control unwanted immune responses in persons with autoimmune diseases.

4-1BB Ligand↗
PubMedDate not supplied

[Levels of family caregiving expected by elderly inpatients].

This study of elderly in-patient subjects' expected level of care given by family members and nurses is intended to provide foundational information for use by nurses in attending to elderly patients. The objects of the study were elderly in-patients over the age of 65 hospitalized at two General hospitals in Chonju; 102 subjects filled out the 60 question survey between December 16 and 24, 1996. The analysis process was conducted using SPSS producing percentage, mean and standard deviation, maximum and minimum values, t-test, ANOVA, and so on. The results are as follows: 1. From the general results of the survey, one can observe that statistically significant differences appeared in various levels of education of the subjects: no education(2.98), primary school completed(2.91), middle school or higher completed(2.77). As shown, the lower level of education correlates with higher care-giving expectation. 2. On a scale of 1(minimum) to 4(maximum), the mean levels of care expected by elderly in-patients from their families is 2.93, with a standard deviation of 0.28. The level of psychological care expected(mean 3.02, standard deviation 0.31) is higher than the level of care expected(mean 2.83, standard deviation 0.34). 3. The level of care expected among those of different levels of dependency for daily living (differentiated as dependent, partially dependent, independent) was highest among the partially dependent(mean 2.98, standard deviation 0.17), but the results were not statistically significant. 4. Elderly in-patients with high levels of emotive interaction with their families expected relatively high levels of physical care, while the highest levels of socio-psychological care were expected from those who reported normal levels of emotive interaction with their families. However, We can see that low levels of care are expected from those reporting low levels of emotive interaction with their families. Overall, the differences in the level of care expected between those reporting different levels of emotive interaction with their families was not shown to be statistically significant.

Activities of Daily Living↗