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Biomedical subjects

K M Hanson

Publications and source records attributed to K M Hanson.

At least 37 records · Page 2Linked to original sources

A new substrate for the rapid evaluation of enteric microbial overgrowth.

The possibility of a new approach to diagnosis of intestinal bacterial overgrowth has been evaluated in laboratory animals. The diagnostic test involves oral administration of an enzyme-labile substrate consisting of para-aminobenzoic acid (PABA) conjugated to a bile acid. In the presence of enteric bacteria, PABA is split from the bile acid and is rapidly absorbed and excreted in the urine. The amount of PABA recovered during the 6 hr following the administered dose of the conjugate may be used as an index of bacterial overgrowth in the upper-gastrointestinal tract. The procedure has been shown to be a reliable index of this condition in laboratory animal models.

Aminobenzoates↗

Splanchnic vascular responses to the infusion of prostaglandins A1, A2 and B1.

The effects of PGA1, PGA2 and PGB1 on the vasculature of the liver and small intestine were studied in 73 dogs. Infusions were made into a branch of the superior mesenteric artery, the hepatic artery, portal vein or femoral vein. They decreased systemic arterial pressure and dilated the hepatic arterial and prehepatic splanchnic (small intestinal) vascular beds, PGA being most active. Dilator response was not decreased by beta-adrenergic blockade. Compounds appear to be inactivated by liver and decreased systemic pressure less when infused directly into liver circulation. Dilator response was transient, particulary in small intestine, and abated or even converted to constriction when infusion was continued for a period of time. Intrahepatic portal venous vasculature appeared to be constricted by PGA.

Animals↗

Hepatic, vascular and biliary responses to infusion of gastrointestinal hormones and bile salts.

The effects of secretin, cholecystokinin, synthetic pentagastrin, sodium dehydrocholate and sodium taurocholate on hemodynamics of the canine liver were studied in a total of 57 dogs. Bile flow was also measured. Dehydrocholate and cholecystokinin significantly decreased systemic arterial pressure while the other substances did not. Hepatic arterial vessels were dilated by pentagastrin and the bile salts; however, flow was not increased in the latter case. Intraheptic portal venous resistance was decreased by pentagastrin and increased by the bile salts. Portal flow was decreased by the bile salts and increased by pentagastrin. Apart from this, mean changes in portal venous flow and portal pressure were not statistically significant. All were potent choleretic agents except pentagastrin which produced only a relatively small transient increase in bile flow.

Animals↗

Determinants of variability among nations in child growth.

This cross-national study aimed at understanding variability in growth among nations and its determinants. It examined the variability of growth among nations, the factors most important for explaining this variability, how these factors jointly determine growth, and the consistency of the patterns and relationships. A conceptual model was adapted from U. Jonsson. National data on height and weight of children, sex, ethnicity, and 15 social, economic, health, education, and political factors were combined from three secondary sources. A sequence of multiple linear regression models was used with three age groups: 1-2, 3-5, and 6-10 years. Substantial variability in growth among nations was seen in comparison to that within nations. Regression models with sex, ethnicity, food security, maternal and child care, and health services and environment explained a large percentage of this variability. Institutions, politics/ideology, economic structure, and potential resources contributed little additionally to the models. Ethnic differences among nations were observed and persisted even when models controlled for other factors, but should not necessarily be interpreted as genetic differences. Determinants for height, weight, and weight adjusted for height were somewhat different. Adjustment for only previous growth and sex explained about 90% of variability in growth, supporting the assumption that growth patterns are generally established early in life. As policy decisions and programmes addressing mild-to-moderate malnutrition are increasingly considered, the implications of cross-national variability in growth may assume greater importance. Future work should examine simultaneously the effects of national, community, family, and individual characteristics on growth using data from individuals in a number of nations.

Anthropometry↗

Detectability in computed tomographic images.

The detection limitations inherent in statistically limited computed tomographic (CT) images are described through the application of signal detection theory. The detectability of large-area, low-contrast objects is shown to be chiefly dependent upon the low-frequency content of the noise power spectral density. For projection data containg uncorrelated noise, the resulting ramplike, low-frequency behavior of the noise power spectrum of CT reconstructions may be conveniently characterized by the number of noise-equivalent x-ray quanta (NEQ) detected in the projection measurements. The NEQ for a given image may be determined either from a measurement of the noise power spectrum or from the noise granularity computed with an appropriate weighting function. A measure of the efficiency of scanner dose utilization is proposed which compares the average dose to that required by an ideal scanner to obtain the same NEQ.

Humans↗

Evaluation of edge-induced streaking artifacts in CT scanners.

A phantom is presented which permits the evaluation of streaking artifacts produced in CT reconstructions by abrupt edges. Its application is demonstrated by results obtained from nine CT scanners. It is observed that even in regions where streaking is not readily apparent, edge-induced artifacts can significantly increase the variance in the reconstruction.

Evaluation Studies as Topic↗