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K M Butt

Publications and source records attributed to K M Butt.

At least 55 records · Page 3Linked to original sources
PubMed1986

Visualization of c-Ki-ras-2 oncogene sequences in human pancreas, a chemically induced transplantable carcinoma, and carcinomas of pancreas by in situ hybridization.

c-Ki-ras-2 sequences were visualized in paraffin-embedded sections from normal fetal and adult human pancreases, a chemically induced transplantable human pancreas carcinoma (PT-1) and three carcinomas of pancreas by in situ hybridization technique. A biotinylated 1-kilobase-pair (kb) EcoRI fragment of pHiHi3 DNA was used as probe and the oncogene was visualized as one or two large grains of reaction products produced by streptavidin-peroxidase complex and diaminobenzidine tetrachloride in more than 9% of normal pancreas nuclei. Its amplification in the chemically induced cell line was detected as one or more large grains in 72% of the nuclei and numerous cytoplasmic grains. The detection of oncogene in normal pancreases and its amplification in PT-1 cells was validated by Southern analysis of EcoRI digests of genomic DNA extracted from normal pancreases and PT-1 cell line. The oncogene was also demonstrated to be equally amplified in two adenocarcinomas and one undifferentiated carcinoma of human pancreas by in situ hybridization.

Adenocarcinoma↗
PubMed1985

Stenotic lesions in dialysis-access fistulas: treatment by transluminal angioplasty using high-pressure balloons.

Eighty-four balloon dilatations of dialysis-access fistulas have been performed over a five year period. Fifty-two were done with polyethylene balloons and the last 32 with high-pressure Olbert balloons. Initial success was significantly greater with the high-pressure balloons, but long-term patency rates were similar. Use of high-pressure balloons and long inflation times is the method of choice for dilating venostenotic lesions in access fistulas.

Angioplasty, Balloon↗
PubMed1985

Posttransplant diabetes in kidney transplant recipients.

We retrospectively reviewed the course of 1,000 renal transplants performed in 835 recipients (758 nondiabetics) to assess the incidence of new onset posttransplant diabetes in former nondiabetics. A total of 119 (15.7%) recipients manifested posttransplant diabetes, of whom 64 (53.8%) became hyperglycemic within 3 weeks of transplantation. Actuarial survival analysis indicated a statistically significant selection of blacks; 68 (57.1%) in the group of posttransplant diabetics contrasted with 30.4% of the overall series who were black (p = less than 0.01). Males comprised 73 (61.3%) of posttransplant diabetics, consistent with the male proportion of 66.6% in the entire series. The total dose of methylprednisolone administered before onset of posttransplant diabetes was less than 2.5 g in 86 (69%) and less than 5 g in 110 (92%) patients. Familial diabetes had been noted in 12 (10%) posttransplant diabetics and in 10 (9%) controls. New cases of posttransplant diabetes occurred at a relatively constant annual rate over the decade of study (+/- 15%/year). Patient survival in controls was greater than in posttransplant diabetics, reaching significance (83 vs. 67%) at 2 years. Kidney graft survival in controls and posttransplant diabetics was similar. We conclude that posttransplant diabetes is of greater prevalence in blacks, is not proportional to total dose or duration of intravenous methylprednisolone therapy, and imposes a threat to recipient survival.

Actuarial Analysis↗
PubMed1985

Cefoperazone therapy of complicated urinary tract infections: pharmacokinetics in renal transplant recipients.

Cefoperazone was used to treat patients with complicated urinary tract infections due to multiple antibiotic-resistant gram-negative rods who had failed prior courses of intravenous antibiotic therapy. Cure was achieved in 44% (4/9) of cases; 44% of patients improved but relapsed and 11% (1/9) of patients were reinfected. Relapse and reinfection were associated with Pseudomonas aeruginosa and/or with conditions not normally responsive to medical therapy alone including prostatitis, reflux and chronic indwelling Foley catheters. The pharmacokinetics of cefoperazone were studied in renal transplant recipients. Peak serum concentrations (range 146-241 micrograms/ml) and 2-hour noncumulative urine concentrations (range 161-291 micrograms/ml) exceeded the minimal inhibitory concentrations of the bacteria in all cases. There was no accumulation of cefoperazone despite the presence of impaired renal function.

Adult↗
PubMed1985

The use of captopril to control hypertension in post-transplant renal artery stenosis.

Captopril is a new orally active angiotensin converting enzyme inhibitor that is useful for the treatment of hypertension. Prior reports have cautioned against its use for the control of blood pressure in patients with transplant renal artery stenosis since it caused a reversible renal failure. We describe a four year old child with radiographically proven transplant renal artery stenosis and severe hypertension that was safely managed with long-term administration of captopril. This case highlights the continued therapeutic role of this drug in the treatment of post-transplant hypertension, provided one carefully monitors the renal function in such patients.

Captopril↗
PubMed1984

Cavitary Legionnaires' pneumonia: nosocomial infection in renal transplant recipients.

Cavitation is an unusual manifestation of legionnaires' pneumonia. Mortality rates range from 24 to 58 percent with effective therapy. Antibiotic therapy is not standardized and is largely based on anecdotal reports. This report has described nosocomially acquired cavitary legionnaires' pneumonia in five renal transplant recipients. The diagnosis was made by seroconversion and immunofluorescent staining of lung tissue or transtracheal aspirates. Frequently seen associated symptoms were not present. All patients were successfully treated with 2 to 4 g of erythromycin for at least 4 weeks.

Adult↗
PubMed1984

Dialysis access fistulas: treatment of stenoses by transluminal angioplasty.

Fifty-six balloon dilatations in 51 patients with upper-extremity dialysis access fistulas were performed over a 4-year period. Forty-four venous anastomotic lesions in patients with either internal or graft fistulas were dilated. Three arterial anastomotic lesions and nine distant venous stenoses were treated. Thirty-nine of 56 (70%) dilatations were initially successful. Of the initial successes, 28/35 (80%) were patent at 3 months, 19/27 (70%) at 6 months, 12/22 (55%) at 1 year, 7/14 (50%) at 2 years, and 3/9 (33%) at 3 years. Three complications (5%) were encountered. These included two graft thromboses and one pseudoaneurysm at the dilatation site. The procedure may be performed on an outpatient basis.

Adult↗
PubMed1984

Hypertension jeopardizes diabetic patients following renal transplant.

Hypertension is highly prevalent in both types I (87%) and type II (95) uremic diabetics at the time of kidney transplantation. Hypertension was diagnosed a mean of 16.9 yrs in type I, and 2.9 yrs in type II diabetics after the clinical diagnosis of diabetes was made. The majority (81%) of our patients were hypertensive postkidney transplant. Only 13% of hypertensive recipients became normotensive post-transplant. This group had a lower mortality rate (1/8, 12.5%), and all survivors (100%) had good graft function (mean creatinine = 1.6 +/- 0.6, range 0.9 to 2.5 mg/dl). By contrast, recipients who remained hypertensive post-transplantation had a much higher mortality rate (25/54, 48%), and loss of graft function necessitating dialysis occurred frequently (19/54, 35%). Of hypertensive diabetic recipients alive at a mean of 21 mos post-transplant, renal function was worse (mean creatinine = 3.1 +/- 3.0, range 1.0 to 13.7 mg/dl) than in nonhypertensive recipients. We conclude that while renal transplantation may be the treatment of choice in patients with diabetes mellitus, failure to control hypertension negatively biases the ultimate post-transplant course.

Diabetes Mellitus, Type 1↗
PubMed1983

Long-term evaluation of children with nephrotic syndrome and focal segmental glomerular sclerosis.

We studied the long-term outcome of a group of children with the nephrotic syndrome who showed the histological lesion of focal segmental glomerular sclerosis (FSGS) during the course of their illness. Of 25 such children studied, a complete follow-up ranging from 3 to 19 years was available in 24. Two distinct groups could be identified. Patients in the first group were characterized by steroid resistance (SR) from the onset, whereas those in the second group were initially steroid sensitive (SS), and had the histological lesion of minimal change which, over time, evolved into FSGS. SR patients had a mean age of 7.7 +/- 3.7 years compared to SS patients who were 3.5 +/- 2.5 years old (p less than 0.01). There were more females (11 of 14) in the SR group than in the SS group (3 of 10; p less than 0.02). The incidence of hematuria was higher in the SR patients (9 of 14) than SS patients (2 of 10; p less than 0.05). SR patients also exhibited a greater degree of growth retardation at the end of the follow-up period (9 of 13 compared to 1 of 8 SS patients; p less than 0.02). SR patients reached end-stage renal failure earlier (2.3 +/- 1.3 years) than SS patients (10 +/- 5.8 years; p less than 0.01) after the initial biopsy. Of the 13 kidney transplanted into 9 SR patients, recurrence of FSGS was noted in two allografts. Of the 4 kidneys transplanted into 2 SS patients, recurrence was seen in 1. The overall recurrence rate of FSGS in allografts was 17.6%. Our study suggests that the two varieties of FSGS occurring in nephrotic patients may be distinct nosologic entities rather than a single disease with varied manifestations.

Adolescent↗
PubMed1982

Pseudohypoaldosteronism following kidney transplantation.

A 56-year-old woman received a kidney transplant and presented subsequently with evidence of volume contraction, hyponatremia and hyperkalemia. Urinary sodium excretion was inappropriately high for the degree of volume contraction and urinary potassium excretion inappropriately low for the degree of hyperkalemia. Marked elevation of plasma renin activity and plasma aldosterone suggested that the renal tubules were unresponsive to mineralocorticoids. The defect was shown to be transient. The mechanisms leading to the defect are discussed.

Aldosterone↗
PubMed1981

Focal angiographic findings in renal transplant rejection.

The angiographic signs of renal allograft rejection are usually diffusely seen throughout the kidney. Three cases of focal rejection are presented including one with histologic confirmation. Possible etiologic mechanisms are discussed. The presence of focal findings at angiography should not rule out the diagnosis of rejection.

Adult↗