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Biomedical subjects

K Long

Publications and source records attributed to K Long.

At least 37 records · Page 2Linked to original sources
PubMed1993

Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.

Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and 7.74 mumol.L-1, respectively. Gla A 10 and 100 mumol.L-1 increased the cAMP levels in platelets. In combination with imazodan hydrochloride, Gla A (1-100 mumol.L-1) caused a marked increase of platelet cAMP levels, while no effect with PGE1.

Animals↗
PubMed1993

Tamoxifen.

Explore the source record for details and available documents.

Breast Neoplasms↗
PubMed1992

Emergent leadership and female sex role identity.

The effects of female sex role identity on self- and rater evaluations of emergent leadership behavior were compared in two studies. We used the same consensus-seeking procedure in both studies to collect the data; only the biological sex composition of the groups in the second study was changed. Study 1 examined 15 mixed-sex groups of 39 female and 21 male students; Study 2 contained 96 female students in 22 same-sex groups. Sex role orientation was measured with the Bem Sex Role Inventory (BSRI: Bem, 1974). Androgynous and feminine-oriented self-ratings of leadership were significantly higher than peer ratings and were also significantly higher than the undifferentiated self-ratings. The self-ratings of masculine-oriented women agreed most closely with peer ratings. Contrary to research and theory, peer evaluation of leadership behavior by sex role orientation did not differ.

Adult↗
PubMed1991

[Effects of econazole and clotrimazole on TXB2 and PGE2 production in calcimycin-stimulated neutrophils and arachidonic acid-stimulated platelets].

The effects of econazole and clotrimazole which are used as antifungal agents, on TXB2 and PGE2 production in calcimycin (A-23187)-stimulated rat pleural neutrophils and arachidonic acid (AA)-stimulated washing rabbit platelets were examined by radioimmunoassay. Econazole and clotrimazole 0.05-100 mumol.L-1 inhibited TXB2 production both in rat pleural neutrophils and in rabbit platelets with a dose-dependent manner. The most potent inhibition was found in rabbit platelets. At the concentration of 50 mumol.L-1, econazole and clotrimazole were sufficient to inhibit TXB2 production in rabbit platelets by up to 99% and 98% respectively. Econazole and clotrimazole 0.05-5 mumol.L-1 also increased PGE2 biosynthesis in rabbit platelets. But econazole and clotrimazole 50 mumol.L-1 reduced the PGE2 production in rabbit platelets to 11% and 37% of the amounts of 5 mumol.L-1 econazole and clotrimazole respectively. The results suggest that econazole and clotrimazole at lower concentration may have a selective inhibitory effect on thromboxane synthetase, at higher concentration they also inhibit cyclooxygenase.

Animals↗
PubMed1991

Effects of CI-930 on hemostasis, thrombosis, and AA-induced hemodynamic reaction.

In mice, CI-930 0.5-2 mg.kg-1 ip not only prolonged the tail bleeding time but also protected the mice from sudden thromboembolic death induced by arachidonic acid (AA, 100 mg.kg-1, i.v.) or TXA2/PGH2 mimetic U46619 (200 micrograms.kg-1, i.v.). CI-930 0.625 and 2.5 mg.kg-1 i.v. exhibited a dose-dependent inhibitory effect on thrombus formation in rat arteriovenous shunt. All these effects of CI-930 were more potent than those of dazoxiben, a known antiplatelet drug. In rabbit, AA 0.75 mg.kg-1 i.v. caused a rapid and marked increase in pulmonary vascular resistance and a concomitant sharp decrease in cardiac output and carotid arterial pressure. CI-930 itself 0.5 mg.kg-1 i.v. resulted in a long-lasting fall in carotid arterial pressure, systemic vascular resistance, and a slight decrease in cardiac output. In addition, CI-930 protected rabbit from all the harmful hemodynamic responses to the occlusion of pulmonary microcirculation, which was induced by AA. The results suggest that CI-930 possess a potent anti-hemostatic, antithrombotic, and probably antihypertensive effects on experimental animals.

Animals↗