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Biomedical subjects

K Lindenhayn

Publications and source records attributed to K Lindenhayn.

At least 37 records · Page 2Linked to original sources
PubMed1982

On the action of prednisolone and ethane-1-hydroxy-1,1-diphosphonate (EHDP) on rabbit bone.

Ethane-1-hydroxy-1,1-diphosphonate (EHDP) (0.1 mg and 1 mg P/kg) and prednisolone (3.7 mg/kg) were administered separately and in combination to young rabbits for a period of 100 days. The results of the experiment show that EHDP is able to reduce the loss of bone substance per unit volume caused by prednisolone. The histological changes in the epiphyseal cartilage noted after prednisolone are not influenced by diphosphonate. The marked formation of fat marrow demonstrable in the prednisolone group does not occur in the prednisolone-diphosphonate group.

Animals↗
PubMed1980

[On the influence of D-penicillamine on collage metabolism - investigations of the rupture of strength in tailfibre in rats of several ages (author's transl)].

The tensile strength of rat tail tendons of animals wtih a different age is more influenced by D-Penicillamine (DPA) in younger rats than in elderly rats. DPA has the best effect in the regions with the highest collagen turnover. After the use of DPA the collagen of tails of the elderly rats resembles the collagen of the younger animals. The reason of this alteration is probably a lower degree of cross-links of the collagen after the use of DPA.

Aging↗
PubMed1979

[Phosphonates and their importance for dental practice].

In the light of a literature review, the author deals with the significance of anorganic pyrophosphate in the mineralization process in the organism. Diphosphonates are synthetic substances which act on mineralisation. The author made experiments with them, the results of which might be of importance in the stomatological sphere with regard to caries reduction and plaque inhibition.

Animals↗
PubMed1979

Effect of dimethylaminomethylendiphosphonate on the immobilisation osteoporosis in rats.

The influence of the immobilization on the bone by the resection of the N. ischiadicus has been examined in rats, 130--150 g and 400 g of weight. The simultaneous administration of dimethylaminomethylendiphosphonate uses to lower the differences in respect to osteodissimilation between the immobilized and not immobilized extremity, caused by immobilization.

Animals↗
PubMed1978

[On the treatment of the osteodystrophia deformans (Paget's disease) with synthetic salmon calcitonin (author's transl)].

Sixteen patients with Paget's disease of bone aged from 51 to 80 years was treated daily with 20 micrograms (equivalent to 80 MRCU) synthetic salmon calcitonin. Fourteen patients was observed on a long time. In all cases was observed significant reductions in increased serum alkaline phosphatase. The urinary hydroxyproline excretion was also decreased. Other laboratory dates as serum calcium, serum phosphorus, serum acide phosphatase, urinary calcium and phosphorus excretion was not significantly influenced by the therapy. The treatment produced a clear remission of pain. After treatment of 6 months the dose was reduced (2 or 3 injections subcutaneously of 20 micrograms salmon calcitonin weekly). There was observed a recurrence of pain and an increase of serum alkaline phosphatase, but not until the pretreatment values. These results confirm the effectiveness of calcitonin treatment in Paget's disease of bone.

Aged↗
PubMed1975

On the effect of prednisolone on hamster bone.

Over a period of 10.8 weeks 0.4, 4.0 or 40.0 mg, respectively of prednisolone bisuccinate/kg/day were injected intramuscularly into Syrian golden hamsters with a body weight of about 100 g. The dosage of 4.0 mg of prednisolone/kg did not produce any osteoporotic changes. The modulus of elasticity and the fracture load of the bones under investigation did not differ from the values obtained in control animals. At a dosage of 0.4 mg of prednisolone/kg/day the values of analysis (density, ash/cm3, calcium/cm3 and hydroxyproline/cm3) decreased by 5-8 percent, and at a dosage of 40.0 mg of prednisolone/kg/day even by 20-34 per cent as compared with the control group. The modulus of elasticity and the fracture load were significantly changed.

Animals↗