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Biomedical subjects

K Limpaphayom

Publications and source records attributed to K Limpaphayom.

30 records · Page 2Linked to original sources
PubMed1997

Bone loss in oophorectomized Thai women.

This prospective analysis was done in 95 postmenopausal women to observe bone loss rate between 59 natural and 36 surgical menopausal women with or without hormonal replacement therapy (HRT). Bone mass measurement was performed at lumbar spines (L1-L4) and hip by dual energy X-ray absorptiometer at 0, 6 and 12 months. The results revealed that in the non-HRT group there was significant faster bone loss rate of lumbar spines (LS) and hip (H) of the surgical group at 12 months (Natural group: LS = -1.11%, H = +2.38%; Surgical group: LS = -4.51%, H = -0.66%, P < 0.05). However, there was no significant difference in bone changes of lumbar spines and hip between natural and surgical group with HRT at 12 months (Natural: LS = +2.0%, H = +4.06%; Surgical: LS = +0.62%, H = +2.28%, P > 0.05). This observation showed that without HRT oophorectomized women had greater magnitude of bone loss than women who entered menopause naturally.

Bone Density↗
PubMed1996

Assessment of tubal patency by transvaginal sonographic hydrotubation with color Doppler flow.

OBJECTIVE: To assess the value of transvaginal sonographic hydrotubation with color Doppler flow (TSH) as a test of tubal patency. METHODS: Thirty-nine women undergoing infertility investigation at Chulalongkorn Hospital participated in this prospective, blind comparative study. Before diagnostic laparoscopy (DL) with chromopertubation, TSH was performed using the SSD 680, 5 MHz vaginal ultrasound probe and 20-50 ml of saline was injected into the uterine cavity. RESULTS: Nine cases could not be evaluated properly. Of the 30 cases, there were complete agreements between TSH and DL in 24 (80%), partial agreement in 5 (16.67%) and non-agreement in 1 (3.33%). TSH had sensitivity 100%; specificity 84.62%, positive predictive value 50%, negative predictive value 100%, false positive rate 15.38%, but no false negative rate. CONCLUSION: TSH is a simple diagnostic procedure for screening of tubal patency. However, other confirmatory test is needed if tubal occlusion is suspected.

Fallopian Tube Patency Tests↗
PubMed1996

The effectiveness of hormone in relieving menopausal symptoms.

To assess the effectiveness of hormone replacement in relieving menopausal symptoms, 75 natural menopausal women suffering from these symptoms were recruited for this double-blind, placebo controlled study. These women were randomized into 2 groups. In the first eight weeks, the first group received a sequential regimen of Estradiol valerate 2 mg/day for 21 days and Norgestrel 0.5 mg/day from day 12 to 21, with seven days of drug-free interval, for two cycles. In the last eight weeks, placebo was given in the same fashion. In the second group, placebo was given in the first eight weeks, then hormone in the last eight weeks. The menopausal scores were recorded by the patients at weeks 0, 4, 8, 12 and 16. Sixty women completed the 16 week study, of which there were 30 women in each group. The mean menopausal score by eight weeks decreased significantly in the first group compared to the pretreatment value (The scores at week 0 and 8 = 20.03 and 12.63 respectively, p < 0.05). However, there was no significant change of the score in the second group. (The scores at week 0 and 8 = 21.20 and 19.43 respectively, p > 0.05). After switching from hormone to placebo in the first group, there was no significant change in mean menopausal score (The scores at week 8 and 16 = 12.63 and 13.73 respectively, p > 0.05). Nevertheless, when switching from placebo to hormone in the second group, the score decreased significantly. (The scores at week 8 and 16 = 19.43 and 13.20 respectively, p < 0.05). In conclusion, this study demonstrated the beneficial effects of hormone replacement in relieving menopausal symptoms.

Cross-Over Studies↗
PubMed1996

Hormonal replacement and lipid changes in postmenopausal women.

To assess the effect of hormonal replacement therapy on lipid changes, measurement of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein A-1 (Apo-A) and apolipoprotein B (Apo-B) was performed on 93 postmenopausal women. Women in the study group (HRT) (51/93) received estrogen with or without progestin. The control group (Non-HRT) (42/93) did not receive any hormone regimen. The measurement was done at 0, 6 and 12 months. The results revealed that triglyceride increased significantly more in the non-HRT than the HRT group at 6 and 12 months. (Non-HRT: +21.7%, +21.7%; HRT: -2.8%, +2.4%, respectively P < 0.05). However, there was no significant difference in changes of other lipid profiles between the two groups at 6 and 12 months (Non-HRT: TC -2.7%, +0.7%, HDL +2.9%, +5.1%, LDL -5.2%, -4.1%, Apo-A +0.5%, +0.9%, Apo-B +3.8%, +1.3%: HRT: TC -1.4%, -2.8%, HDL +4.7%, +6.2%, LDL -1.5%, -4.9%, Apo-A -0.9%, +1.6%, Apo-B -2.6%, -1.6%, respectively P > 0.05). The paradoxical changes of triglyceride and HDL might partly be explained by the effect of progestins used in this study.

Estrogen Replacement Therapy↗
PubMed1995

Bone changes in postmenopausal Thai women with or without hormonal replacement therapy.

UNLABELLED: Bone mass measurement was performed in 95 healthy postmenopausal women to assess the effect of hormonal replacement therapy (HRT) on bone changes. Women in the study group (51/95) received estrogen with or without progestin. The control group (44/95) did not receive any hormone regimen. The measurement was done at lumbar spines (L1-L4) and hip by dual energy X-ray absorptiometer at 0, 6 and 12 months. The results revealed significantly higher per cent changes of bone density of lumbar spines and hip, at 12 months, in the study group than in the control. ( STUDY: Lumbar Spine +1.76%, Hip +3.57%; CONTROL: Lumbar spines -2.32%, Hip +1.32%, P < 0.05). In conclusion, this study showed the value of hormonal replacement therapy for prevention of postmenopausal bone loss in Thai women.

Absorptiometry, Photon↗
PubMed1991

Sterilization.

Sterilization has become the most widely used method of family planning in both the developed and developing world. This article discusses the importance of presterilization counseling and describes the timing of the procedure, methods of anesthesia, and occlusion techniques (eg, tubal ligation and the use of rings and clips) in female sterilization. Other topics covered in sterilization of women are long-term follow-up and complications, reversal of sterilization, impact of national sterilization policies, and nonsurgical sterilization. The article includes a short section on surgical contraception for men.

Anesthesia↗
PubMed1986

Tubotubal anastomosis for reversal of female sterilization in Thailand.

From September 1979 to December 1983, 168 women requested sterilization reversal. Forty-four of them were selected for tubotubal anastomosis, employing a microsurgical technique. The mean age was 28.7 years (range, 22-37), the mean number of pregnancies was 2.0 (range, 0-3), and the mean number of living children was 1.6 (range, 0-3). The main reason for the reversal request was remarriage (63.63%). The overall crude rate of full-term intrauterine pregnancies resulting in live births was 61.4%. The ectopic pregnancy rate was 4.5% and the abortion rate, 2.3%. Three cases were lost to follow-up. Life-table analysis revealed a cumulative pregnancy rate of 77% one year after surgery and 80% two years after surgery.

Abortion, Spontaneous↗
PubMed1984

Microsurgical tubal anastomosis: a controlled trial in four Asian centers.

An international program to determine the reversibility of female sterilization in Asia using microsurgical technique was established in 1980. One hundred eleven of 219 patients (51%) conceived following tubal anastomosis; of these, 79 delivered living children. The overall cumulative probability of conception at the end of follow-up, as determined by life-table analysis, was 63%. A decreased pregnancy rate was associated with anastomosis of tubes sterilized by electrocautery methods.

Adult↗
PubMed1980

Laparoscopic tubal electrocoagulation for sterilization: 5000 cases.

Five thousand cases of laparoscopic tubal electrocoagulation were performed for voluntary interval sterilization in outpatient Thai women from January 1974 through June 1978. Immediate complications occurring during surgery resulted from mesosalpingeal hemorrhage, which was successfully managed by omental packing with or without repeated electrocoagulation. The overall failure rate was 0.40%. The authors find this method of tubal electrocoagulation for fertility management to be reliable and safe as an outpatient procedure and to provide rapid convalescence.

Electrocoagulation↗