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Biomedical subjects

K Levine

Publications and source records attributed to K Levine.

23 records · Page 2Linked to original sources

Sodium restriction in hypertension.

Hypertensive patients, treated or untreated, benefit from sodium restriction. Need for fewer drugs, less hypokalemia if thiazide-diuretic treated, and lower blood pressures should result from successful reduction of sodium intake. A planned program using behavior modification principles can help patients make the necessary changes in their eating habits. Monitoring blood pressure and urinary sodium excretion will give evidence of adherence to the diet.

Behavior Therapy↗

Femoropopliteal bypass: the preferred site for distal anastomosis.

In many patients undergoing femoropopliteal bypass, an occluded superficial femoral artery may reconstitute at the adductor canal and the popliteal artery will be patent. For these patients, uncertainty exists as to whether the preferred site for the distal anastomosis is an above-knee (AK) or below-knee (BK) bypass graft. Operation is, therefore, often based on personal preference rather than fact. To evaluate this problem, we undertook a 6-year review of the cases of 90 patients who had femoropopliteal bypass to a patent popliteal artery. Seventy AK bypass grafts were performed: 20 with autogenous vein, 25 with Dacron, and 25 with polytetrafluoroethylene (PTFE). Based on the life table analysis method, the late patency rate was 70% for vein, 68% for PTFE, and 64% for Dacron. These results were compared against results in 25 patients who had BK femoropopliteal bypass with autogenous vein, in whom the late patency rate was 65%. There was no statistical difference between these groups (P less than 0.25). An AK femoropopliteal bypass with a prosthesis yielded long-term patency rates that were similar to those of AK or BK vein grafts. When the popliteal artery is patent and the distal anastomosis can be done proximal to the knee joint, a prosthetic graft should be used. A prosthetic graft will reduce operative time, shorten recuperation time, and spare the saphenous vein for use in the coronary or infrapopliteal vessels if the need arises.

Adult↗

Hycanthone: a frameshift mutagen.

Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.

Anthelmintics↗

A simplified approach for correction of bilateral renal and aortoiliac occlusive disease.

Aortorenal bypass procedures have utilized autogenous artery, vein, and synthetic materials in the surgical management of atherosclerotic renal artery occlusive disease. When concomitant bilateral renal artery and aortic occlusive disease is identified, transaortic bilateral renal artery endarterectomy and aortoiliac/femoral bypass grafting is a safe and simplified technique which does not share the attendant problem and technical difficulties of aortorenal bypass operations.

Adult↗