Biomedical subjects

K Lehmann

Publications and source records attributed to K Lehmann.

At least 145 records · Page 8Linked to original sources

PubMed1975

[The correlation of clinical-electrocardiographic criteria with pathologic-anatomical findings in myocardial infarct].

Electrocardiographic signs of myocardial infarction obtained in 591 patients by the corrected orthogonal lead system according to Frank were compared with corresponding results of autopsy-proven material and corrected. By the corrected orthogonal lead system myocardial infarction could be recognized in 89% of the autopsy-proven cases. Moreover, electrocardiographic alterations which suggest accompanying mono- or biventricular hypertrophy were demonstrated.

Adult↗

PubMed1975

[Mechanism of action and kinetics of lithium. I. Biochemical and experimental pharmacological findings after administration of lithium-conclusions on the mechanism of the therapeutic effect of lithium].

A comprehensive consideration of biochemical and pharmacodynamic lithium (Li) effects enabled an explanation of the Li mechanism (Fig 1). According to this concept, Li might possibly affect the activity of membrane-bound ATPases in dependence on the initial situation, dose and duration of application. Research into Li-kinetics suggested the participation of active process in the transport of the ion through the organism. Li-kinetics describes distribution within a multiple-compartment system and, with the exception of the resorption phase, its independent of the anion used. The elimination (half-life time 22 to 25 hrs) is limited by backward flow form the tissue.

Adenosine Triphosphatases↗

PubMed1975

[Kinetics of lithium].

After administration of easily soluble or ready dissolved lithium salts two phases can be defined in the changes of the blood level, and three in the case of lithium salts with a lesser solubility in water. The first phase from the time 0 to tmax is denoted by a massive invasion into the blood, this is counteracted by the beginnings of absorption into the tissue and elimination through the kidneys. In the second phase the absorption into the blood is returned to a constant even distribution; the absorption in the tissue and renal excretion rise notably. When the distribution is completed, the renal excretion is dominant. The kinetics of lithium are independent of the salt used. The salt, however, because of its solubility in oral administration can influence the absorption kinetics, tmax and the absolute blood level. By using Li2CO3 with a suitable speed of solubility a depot effect can be shown.

Biotransformation↗

PubMed1974