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Biomedical subjects

K Lee

Publications and source records attributed to K Lee.

At least 919 records · Page 51Linked to original sources
PubMed1979

Alcoholism and cerebrovascular thrombosis in the young.

The etiology of cerebrovascular thrombosis in normotensives has not been elucidated. This controlled retrospective study examines the association between alcoholism and cerebrovascular thrombosis in patients under age 50. The hospital records of 49 patients under age 50 with a diagnosis of cerebrovascular thrombosis without hypertension were reviewed for possible predisposing factors. Alcohol abuse is the one common denominator among the males in the study.

Adolescent↗
PubMed1978

Effect of cimetidine on renal function in normal man.

To evaluate the effect of acute histamine H2-receptor blockade on renal function, renal function studies were performed in a control state and after cimetidine. Studies included acid excretion in response to acid loading, bicarbonate reabsorption during bicarbonate infusion, and urinary concentrating ability. Cimetidine produced no significant effect on any of these functions. During bicarbonate infusion, inulin clearance remained constant while creatinine clearance fell, possibly because of an effect on tubular creatinine secretion.

Adult↗
PubMed1978

Iron sources used in food fortification and their changes due to food processing.

The effect of food processing on the biological availability of iron in iron-fortified foods is critically reviewed. Studies on changes in the chemistry of the iron in processed foods are examined. Various iron sources currently used in food fortification in the U.S. are defined with emphasis on their biological availabilities under various conditions. The availability of iron in foods depends upon numerous factors, most of which are not fully understood. A factor which is often overlooked is the interaction of the iron with the food during events such as cooking or processing. Chemical changes in the iron compounds occur which may correlate with changes in the biological availability.

Adult↗
PubMed1978

Acute lymphocytic leukemia-associated cell membrane antigen.

Antisera were raised in New Zealand White rabbits against non-B, non-T acute lymphocytic leukemia (ALL) cells coated with antilymphocyte serum. Following minimal absorption with chronic lymphocytic leukemia (CLL) cells, the antiserum reacted mainly with non-B, non-T ALL cells. The following numbers of patients had leukemia cells that reacted with the ALL antisera: 13 of 18 with ALL, 3 of 27 with acute myelocytic leukemia, 1 of 8 with chronic myelocytic leukemia (CML), and 0 of 12 with CLL. The positive CML was a patient in CML blast crisis. Normal peripheral blood B- and T-lymphocytes and normal bone marrow were negative. Reactions of the anti-ALL serum (136K) were compared with the reactions of a rabbit anti-B-cell antiserum (63K) that reacted with approximately 70% of leukemia cells. Cultured lymphoblastoid cell lines from normal donors were negative by both cytotoxicity and immunofluorescence tests. However, by immunofluorescence testing, 8 of 17 known malignant lines from a variety of lymphoproliferative disorders were positive; 4 of these lines were of T-cell origin. By immunoprecipitation and polyacrylamide gel electrophoresis, the ALL antigen appeared to consist of a single polypeptide chain of approximately 98,000 daltons. The anti-ALL antiserum was not cytotoxic for normal myeloid stem cells (colony-forming units).

Adult↗
PubMed1977

Mutagenicity of 22 N-nitrosamides and related compounds for Salmonella typhimurium TA1535.

Twenty-two N-nitrosamides and related compounds, including 14 nitrosoureas, 5 nitrosocarbamates, and one nitrosocyanamide, were tested at various concentrations for mutagenic activity towards Salmonella typhimurium TA1535 without the use of microsomes. The ether-water partition coefficient, solubility in water, and half-life in aqueous solution were also measured. Twenty compounds were mutagenic, with "standard mutagenic concentrations" (i.e. those producing 100 mutants/dish) of 0.0024--6500 micron. Standard mutagenic concentration was negatively correlated with the partition coefficient. Three compounds (ethyl 2-acetoxyethylnitrosocarbamate, nitrosocarbaryl, and methylnitrosobenzamide) were more active than the classic mutagen methylnitrosonitroguanidine. Nitrosocarbamates were at least 50 times more mutagenic than the corresponding nitrosoureas. Nitrosodihydrouracil and propylene-nitrosourea were more active than related compounds. Ethylnitrosocyanamide was 730 times more mutagenic than ethylnitrosourea. Fifteen of the test compounds (of which 14 were mutagenic) had previously been assayed in rats for carcinogenicity, all with positive results.

Amides↗
PubMed1977

Vibrio alginolyticus infections in Hawaii.

Clinical and bacteriological features of eight cases of Vibrio alginolyticus infections in Hawaii are presented. These isolates occurred in superficial sites, primarily related to infections caused by swimming.

Adolescent↗
PubMed1977

Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine.

Radiographs of 175 patients with diffuse idiopathic skeletal hyperostosis (DISH) of the spine or ankylosing spondylitis were reviewed. DISH most frequently began in the middle and lower portions of the thoracic spine; it was rare in the upper portion. A few vertebrae were first affected, and then involvement extended, sometimes throughout the thoracic spine. The anterior and lateral aspects of vertebral bodies were mainly affected. Hyperostosis vertically spanning the anterior aspects of the vertebrae varied in thickness up to 10 mm, and the rate at which the hyperostosis proliferated was not specific for any vertebra. Males were 12 times more frequently affected than females, especially in the older age groups. Diabetes mellitus and hypertension have reportedly been associated with DISH, but no such correlation was found in this study. Despite the existence of criteria for differential diagnosis, it is sometimes difficult to distinguish ankylosing spondylitis from DISH radiologically. The radiologic features helpful in the differential diagnosis are described, and a review of the pertinent literature is included.

Adult↗
PubMed1977

The effect of Marek's disease vaccination and day-old debeaking on the performance of growing pullets and laying hens.

In a 2 X 2 completely randomized factorial design, four hundred day-old Single Comb White Leghorn pullets were randomly assigned to four treatment combinations of vaccinated, non-vaccinated, debeaked and non-debeaked groups. Vaccination and debeaking were performed at day-old by administering 2,000 P.F.U. of HVT vaccine/chick and by removing approximately 2/3 of the upper beak, respectively. All the data were analyzed at 5% level of probability. Vaccination reduced feed consumption significantly only during the early growing period of the first 12 weeks, whereas debeaking caused a significant reduction in feed consumption throughout the experimental period of 80 weeks. Mortality during the 20-week growing period was not affected by either vaccination or debeaking. During the laying period (20-80 weeks of age), vaccination reduced the mortality numerically, while debeaking reduced the mortality significantly. Final body weight, hen-day egg production, egg weight, albumen height and egg shell thickness were not influenced by either vaccination, debeaking or a combination of the two. Debeaking had no effect on the incidence of blood-spotting in the eggs. Vaccination, however, significantly reduced percent blood spots in the eggs. Day-old debeaking effectively prevented the occurrence of cannibalism.

Animals↗
PubMed1977

Unconjugated hyperbilirubinemia in very low birth weight infants.

In very low birth weight infants, the occurrence of bilirubin-related brain damage has been repeatedly observed at low serum bilirubin concentrations in close association with altered pathophysiologic status (hypoxia, acidosis, hypothermia, and so on). This increased susceptibility is accompanied by increased severity and duration of unconjugated hyperbilirubinemia as compared with more mature infants. Clinical manifestations of kernicterus in very low birth weight infants are almost always nonspecific. No single biochemical or physiologic measurement is sufficient to predict the risk for development of the bilirubin-related brain damage in this group. Prevention of bilirubin-related brain damage in very low birth weight infants requires not only the maintenance of physiologic and biochemical milieu within normal limits, but also specific therapy to alleviate unconjugated hyperbilirubinemia. Although exchange transfusion has been the mainstay of therapy for unconjugated hyperbilirubinemia, the increased morbidity and mortality associated with exchange transfusion in these immature infants and the need to maintain very low serum bilirubin concentrations suggest that prophylactic phototherapy may be more beneficial for this group.

Bilirubin↗