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Biomedical subjects

K Lawrence

Publications and source records attributed to K Lawrence.

At least 73 records · Page 4Linked to original sources
PubMed1984

A preliminary study on the use of carbenicillin in snakes.

The results of a 10 year survey on the in vitro antibiotic resistance patterns of Pseudomonas spp. isolated from clinically ill reptiles, showed a high degree of sensitivity to carbenicillin. On the basis of sensitivity testing, carbenicillin was used to treat nine snakes of four different species, with confirmed Pseudomonas infections. Plasma carbenicillin levels were assayed, by a microbiological agar diffusion technique, at intervals of time after a single intramuscular injection at a dose rate of 400 mg/kg. Peak plasma levels of 177 and 270 micrograms/ml were reached 1 h after the initial injection and therapeutic levels persisted for at least 12 h. This initial study indicated that a suggested dose regime in snakes, derived by extrapolation from mammalian dosages, of 100-125 mg/kg daily was insufficient to produce plasma levels of sufficient magnitude and duration to effectively treat Pseudomonas infections in snakes.

Animals↗
PubMed1984

Preliminary study on the use of ceftazidime, a broad spectrum cephalosporin antibiotic, in snakes.

Ceftazidime, a broad spectrum cephalosporin antibiotic with an enhanced anti-pseudomonal activity, was tested in vitro against a variety of reptilian bacterial isolates. Blood concentrations of this antibiotic were determined in clinically ill snakes following an intramuscular injection at a dose rate of 20 mg kg-1. Peak plasma levels of up to 70.5 micrograms ml-1 were reached one to eight hours after the injection and therapeutic plasma levels were maintained for at least 96 hours. A series of snakes treated with ceftazidime at a dose rate of 20 mg kg-1 every 72 hours showed a rapid and obvious clinical response to treatment. The snakes were maintained at 30 degrees C during treatment and the effect of environmental temperature on antibiotic half-life is discussed. Ceftazidime proved to be a highly active antibiotic against the bacteria known to cause disease in reptiles, with no obvious adverse effects having been so far described.

Animals↗
PubMed1983

Efficacy of fenbendazole against nematodes of captive birds.

Fenbendazole was used to treat nematode infestations (Ascaridia species and Capillaria species) in 230 birds of six orders and 38 different species. Using a single dose of 100 mg/kg bodyweight initial treatment eliminated parasitic nematodes from 221 birds. A further course of treatment at a dose rate of 30 mg/kg daily for seven days eliminated the infestation from the remaining nine birds.

Animals↗
PubMed1983

Alphaxalone/alphadolone anaesthesia in reptiles.

The use of alphaxalone/alphadolone in 40 reptiles of 13 species is described. In lizards and chelonians the effect of the drug combination varied from sedation to deep anaesthesia, depending on the dose. For other reasons, the effect in snakes varied, from none at all to deep anaesthesia. No fatalities occurred and there were no apparent clinical side effects in healthy reptiles. The results are discussed and attention is drawn to the apparently equivocal results in snakes.

Anesthesia↗
PubMed1981

Continuing education of health professionals: proposal for a definition of quality.

The present reality of continuing education of health professionals is briefly reviewed: what it can and cannot do and how it differs from preparatory professional education. It is hoped that the application of educational theory and the analysis of the successes and failures of continuing education of the past will result in continuing education being an effective bridge between academia and practice. From a study of educational theory, of adult learning, of management, and of past experience, a model was developed. The model describes quality continuing education and encourages the health professional to assume personal responsibility for learning. The listed elements of quality can be used to introduce a measure of quality to the planning and implementation of continuing education activities. Agencies responsible for the quality of continuing education activities can use the elements to assess activities, products, and services.

Education, Medical, Continuing↗