Western Norway: a high-risk area for MS.
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Humans↗
Biomedical subjects
K Lauer
Publications and source records attributed to K Lauer.
Epidemiological investigations into multiple sclerosis in Southern Hesse. III. The possible influence of occupation on the risk of disease.
In order to discover possible exogenous risk factors in the etiology of multiple sclerosis, the pattern of the patients' occupation during adolescence and at disease onset was analysed in an epidemiological group of MS patients in Southern Hesse (West Germany) and compared with that of the German population in the corresponding years. During adolescence, male patients were more frequently occupied in metal processing and electrical trades and female patients more commonly in commerce and administration than expected. At onset, some more female patients than expected were working in commerce and administration whereas male patients did not deviate from the pattern in the general population.
Adolescent↗
Epidemiological investigations into multiple sclerosis in Southern Hesse. IV. The influence of urban and rural environment on disease risk.
Residence during childhood and at disease onset in urban, semirural and rural communities respectively was investigated in an epidemiological group of MS patients in Southern Hesse (West Germany). Patients originated more frequently from small rural communities and less frequently from provincial towns than expected, whereas residences at onset corresponded to the distribution in the general population. The size of the community of residence did not influence age at onset, the later progression rate or the symptoms at onset.
Adult↗
On the diagnostic value of different CSF investigations in multiple sclerosis.
An assessment was made of the relative values of different methods of calculating intrathecal IgG synthesis in multiple sclerosis. In 60 patients with definite, probable or possible multiple sclerosis the IgG/protein and IgG/albumin ratios, the IgG index, the Tourtellotte formula and the graphic evaluation according to Reiber were applied. All the patients had oligoclonal IgG in the CSF. Reiber's method was the most sensitive, yielding 66% of abnormal findings. Only the cell count showed significant differences between active and inactive stages. There was a correlation between the cell count and the daily rate of intrathecal IgG synthesis and between the latter and the number of oligoclonal bands in CSF, but none of these parameters correlated with duration of disease or the number of previous bouts.
Adolescent↗
Epidemiological investigations into multiple sclerosis in southern Hesse. I. Methodological problems and basic epidemiologic characteristics.
An epidemiological field-survey on multiple sclerosis (MS) was carried out in the southern part of the state of Hesse (West Germany). Out of 472 patients primarily ascertained, 75% could finally be accepted as definite or probable MS cases. Cross-checking of the 3 sources for case-finding (practitioners and specialists, neurological hospital, MS society) revealed that case-finding in all and especially that of definite and probable MS cases was rather complete. The overall prevalence rate was 58.3, the annual incidence 2.15 and the mortality rate 2.0 per 100,000. Male patients showed a faster course than females. The prevalence in immigrants who mostly originated from Mediterranean countries, was significantly lower (14.3 per 100,000) than the prevalence in the German population (63.1 per 100,000).
Adolescent↗
Epidemiological investigations into multiple sclerosis in southern Hesse. II. The distribution of cases in relation to exogenous features.
In order to discover possible exogenous variables associated with a higher multiple sclerosis risk, the distribution of cases with definite and probable multiple sclerosis ascertained in the course of a micro-epidemiologic study in Southern Hesse was evaluated and compared with some environmental factors. The prevalence in 1980, the prevalence of cases with disease-onset within the region according to locality of onset and the rate of native Southern Hesse patients according to childhood residence all showed a similar geographical distribution, with the highest values in the south-eastern, mountainous part of the region. This district has a lower annual mean temperature, more annual snow-days and a higher annual precipitation compared to the remaining area. A statistical comparison revealed no association with industrial or agricultural activities, with a particular type of land use, with cattle, pig- or horse-breeding, or with sanitary or housing standards. On the other hand, a slight association with the soil type could be demonstrated, with higher rates on loam and clay subsoils when compared to predominantly sandy regions. Whether this finding has any significance or not remains to be clarified.
Agriculture↗
[Excretion pattern of cell membrane protein from the proximal tubule in pyelonephritis and toxic kidney damage].
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Adolescent↗