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Biomedical subjects

K Larsson

Publications and source records attributed to K Larsson.

At least 361 records · Page 20Linked to original sources
PubMed1977

Prostaglandin-induced parturition in swine -- a field study on its accuracy after treatment with different amounts of PGF.

This trial was performed within one large piglet producing herd in Sweden during June-August 1976. One hundred and sixty sows were randomly assigned to one of the following treatments: (1) 15 mg PGF2alpha i.m., (2) 20 mg PGF2alpha i.m., (3) two injections of 10 mg PGF2alpha i.m. at c. 8 h interval, (4) untreated countrol sows. PGF2alpha was administered in the morning of days 111, 112 or 113 of pregnancy. Of the PGF2alpha-treated sows, 83--85% farrowed within 48 h after treatment. No effect of day of treatment was found. Nor was any difference between groups observed. Neither of the treatments had a significantly negative influence of the viability of the piglets born. A numerically lower incidence of agalactia post partum was demonstrated in sows treated once with 15 mg or 20 mg PGF2alpha. A possible effect of PGF2alpha for prevention of agalactia post partum is discussed.

Animals↗
PubMed1976

Sexual behavior in castrated male rats treated with monoamine synthesis inhibitors and testosterone.

Castrated male rats treated daily with the 5-HT synthesis inhibitor p-chlorophenylalanine (PCPA, 20 mg/kg) started to display mounts, intromissions and ejaculations more rapidly in response to daily treatment with testosterone propionate (TP, 0.15 mg/kg) than NaCl-treated rats. Daily treatment with the catecholamine (CA) synthesis inhibitor alpha-methyl-p-tyrosine (alpha-MT, 20 mg/kg) had no effect on the behavioral response to subsequent TP treatment. The acceleration of TP-induced sexual behavior by PCPA pretreatment was inhibited by pretreatment with DL-5-HTP (20 mg/kg) but not with L-DOPA (12.5 mg/kg). Analyses of brain monoamines showed that the PCPA treatment reduced brain 5-HT levels and produced a marked inhibition of the 5-HT synthesis. The 5-HTP treatment restored brain 5-HT levels to normal. Daily treatment with PCPA also reduced brain CA levels and inhibited the CA synthesis but these biochemical effects were not related to the effects of PCPA on sexual behavior. Daily treatment with PCPA (40 mg/kg for 12 days) or treatment with 126 mg/kg PCPA for 3 days induced the complete pattern of sexual behavior in 5 of 9 and 19 of 30 castrated rats respectively without concurrent TP treatment. It is suggested that 5-HT exerts a modulating influence on sexual behavior in male rats.

Animals↗
PubMed1976

Stimulation of mounting behavior but not lordosis behavior in ovariectomized female rats by p-chlorophenylalanine.

Treatment with 126 mg/kg of the 5-hydroxytryptamine synthesis inhibitor p-chlorophenylalanine (PCPA) for 3 days or daily treatment with 40 mg/kg of PCPA stimulated the display of mounting behavior, including ejaculatory patterns, by ovariactomized hormonally untreated female rats. PCPA treatment failed to induce lordosis behavior and did not affect the induction of lordosis behavior by daily injections of 2.0 mug/kg estradiol benzoate. These results show that mounting and lordosis behavior can be dissociated and it is suggested that these two sexual behavior patterns may be regulated by different neurotransmission mechanisms.

Animals↗
PubMed1976

Surface balance study of the interaction between microorganisms and lipid monolayer at the air/water interface.

Using the surface balance technique, we have compared the interaction between Acholeplasma laidlawii and some marine bacteria towards different types of monolayered lipid films. Cells from A. laidlawii and Serratia marinorubra penetrate the film, whereas cells from Psuedomonas fluorescens form a layer underneath the film. The forces that bind microorganisms to the air/water interface are not strong enough to scatter a condensed monolayer but increase the strength of loosely packed monolayers.

Acholeplasma laidlawii↗
PubMed1976

A new skin protecting ointment against acrylic resins.

In order to protect the hands of dentists, dental technicians and dental nurses from direct contacts with acrylic monomer, a new type of protective monoglyceride containing ointment has been introduced. The monoglyceride-based ointment was found to prevent penetration of the monomeric part of an autopolymerising acrylic resin and was also shown to have significantly smaller decreasing influence on the ability to manipulate instruments and materials than a compared silicone-based ointment. Furthermore, even with addition of 1% by volume of the monoglyceride-based ointment there was no marked influence on the mechanical properties (elastic modulous and ultimate tensile strength) of an investigated acrylic tray material.

Acrylic Resins↗
PubMed1976

Sequential changes of estrogens and progesterone at prostaglandin-induced parturition in the sow.

Parenteral administration of prostaglandin F2alpha (PGF2alpha) is efficient in inducing parturition in late pregnant swine. The purpose in the present study was to investigate the sequential changes of progesterone and estrogens at prostaglandin-induced parturition in the sow. Six of 7 sows (86%) treated once intramuscularly with 12.5 mg of PGF2alpha on days 110, 111, 112, or 113 of pregnancy farrowed within 39 hours after the injection. One PGF2alpha-treated sow and 2 sows given placebo injections on days 110 and 111 of pregnancy farrowed 90 to 130 hours later. The injection of PGF2alpha decreased the peripheral plasma concentration of progesterone in a manner similar to that observed immediately prepartum in normally farrowing sows. Estrogen patterns were similar in PGF2alpha-treated and control sows.

Animals↗