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Biomedical subjects

K Laake

Publications and source records attributed to K Laake.

At least 73 records · Page 4Linked to original sources
PubMed1988

Prevalence of dementia in a Norwegian sample aged 75 years and over and living at home.

The prevalence of dementia in the age group 75 and over was studied in a random sample of elderly living at home. The MMS and the GMS were used as screening instruments, supplemented by medical history and a physical examination. The dementia diagnosis was confirmed by psychogeriatric assessment and a follow-up after 18 months. The prevalence of dementia in this sample was 10.5%; for severe dementia 3.8%, and for mild dementia 6.7%. Its occurrence was found to be unrelated to gender, marital status, domestic status, and duration of schooling.

Aged↗
PubMed1986

Pharmacokinetics of temazepam in geriatric patients.

A single dose of temazepam 10 mg, as a solution in soft gelatin capsules, was given to 10 fasting geriatric in-patients (mean age 83 years) in a stable clinical condition. The mean peak plasma concentration was 306 ng/ml, with a median time of 0.75 h to peak concentration. Temazepam was eliminated from plasma in a biexponential manner, with a distribution phase (mean t1/2 alpha = 0.7 h) predominating for 3 h. The drug had a mean elimination half-life of 8.7 h. In a chronic study, in which temazepam 10 mg p.o. was given nightly to 13 patients, the plasma concentrations on Days 3, 5, 8, 12 and 15 were not significantly different from each other, showing rapid attainment of steady state levels and the lack of drug accumulation.

Aged↗
PubMed1985

On the problem of measuring the distance between distribution functions: analysis of hospitalization versus mortality.

The relationship between hospitalization, as a measure of morbidity, and mortality is examined. The difference between age at hospitalization in a general medical department and age at death in Oslo, Norway, is studied. The problem is transferred to the one of examining the difference between two cumulative distribution functions F and G. For this purpose, a quantile distance function based on the inverses of the distribution functions is applied. We give the natural estimate of the quantile distance function, and some asymptotic properties of the corresponding empirical process. For the particular situation where one of the distribution functions is known, a confidence band for the quantile distance function is derived. Applying these results, we show that there are reasons to believe that age at hospitalization and age at death are equally distributed, apart from a constant shift.

Adult↗
PubMed1984

Side-effects of piroxicam (Feldene). A one-year material of 103 reports from Norway.

In the first year after registration, 103 reports on suspected adverse reaction to piroxicam (Feldene) were submitted to the Norwegian Adverse Drug Reaction Committee. Eighty-three reactions were classified as probable side-effects, and 73 of these were related to the upper gastrointestinal tract. Peptic ulcer and upper gastrointestinal haemorrhages predominated. Two deaths were classified as probably due to piroxicam. There were 8 life-threatening reactions, all due to haemorrhages. No severe cutaneous reactions were reported. A significant fraction of the gastrointestinal reactions occurred in patients with a previous history of peptic ulcer disease. Nearly every fourth patient with proven ulcer or haematemesis/melaena had simultaneously been taking other drugs with the propensity of causing gastrointestinal haemorrhage. The gastrointestinal adverse reactions to piroxicam can probably be reduced by a more accurate selection of patients.

Aged↗
PubMed1981

Convulsions and possible spasm of the lower oesophageal sphincter in a fatal case of propranolol intoxication.

A fatal case of propranolol intoxication is described. The patient had ingested 3-5 g of the drug and probably no other drugs. Gastric lavage could not be performed due to some kind of obstruction in the distal part of the oesophagus. At autopsy, the oesophagus was normal, and a spasm due to B-blockade is suggested. Epileptiform seizures resistant to treatment with diazepam and barbiturates were frequent and probably not solely caused by cerebral ischaemia.

Adult↗