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Biomedical subjects

K L Richards

Publications and source records attributed to K L Richards.

41 records · Page 3Linked to original sources
PubMed1978

131I-labeled fibrinogen in the diagnosis of deep vein thrombosis of the lower extremities.

Autologous 131I-labeled fibrinogen was administered to 17 patients during 19 episodes of suspected lower extremity deep vein thrombosis in an attempt to assess its diagnostic accuracy. Serial rectilinear scanning and probe counting of the lower extremities and pelvis were performed and compared with ascending contrast venography. The sensitivities of imaging and counting were 67% and 47%, respectively, and both had a specificity of 95%. The experience with evaluation of deep vein thrombosis of the pelvic and iliac veins was small but suggested that 131I fibrinogen will be of limited use in those vessels.

Fibrinogen↗
PubMed1976

Noninvasive diagnosis of deep venous thrombosis.

Eighty-five patients suspected of having lower-extremity deep venous thrombosis (DVT) participated in a prospective study to test the diagnostic accuracy of four noninvasive techniques: Doppler ultrasonic flow study, electrical impedance plethysmography, the serial dilution protamine sulfate test, and an extensive physical examination. Ascending radiocontrast phlebography was the diagnostic standard of reference. We found that (1) when both Doppler and impedance examinations were positive, the diagnosis of DVT could be considered virtually certain; (2) impedance and Doppler examinations, when used in combination, were reliable screening tests capable of establishing or excluding the presence of thigh DVT; (3) physical examination and the serial dilution protamine sulfate test were unreliable screening techniques for DVT; (4) techniques other than the noninvasive methods investigated were needed to reliably detect or to exclude popliteal and call DVT.

Diagnostic Errors↗
PubMedDate not supplied

Molecular definition of the retention parameters of peptides separated by RP-HPLC.

Different physicochemical properties of the constituent amino acid side chains have been employed in order to investigate the molecular basis of the experimentally derived retention parameters, S and log k0, of peptides separated by reversed-phase high performance liquid chromatography (RP-HPLC). The results demonstrate that the S-value is strongly related to the total surface area of a peptide but correlates poorly with the corresponding predicted hydrophobicity based on the summated amino acid group retention coefficients. In contrast, the experimentally derived log k0 value correlates well with both the total surface area and the predicted affinity values derived from the incremental free energy of transfer calculated from the summated amino acid retention coefficients. Since the S and log k0 values are parameters useful to the interpretation of peptide and protein chromatographic behavior in RP-HPLC, the results of the present study document the physicochemical relationships that exist between these retention parameters and peptide structure.

Chemical Phenomena↗