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Biomedical subjects

K L Kubos

Publications and source records attributed to K L Kubos.

24 records · Page 2Linked to original sources
PubMed1984

Asymmetrical effects of unilateral cortical suction lesions: behavioral characterization.

Behavioral effects of unilateral frontocortical suction lesions in the right and left hemisphere were characterized by a computerized activity monitoring system. Lesions of the right frontal cortex produced postoperative hyperactivity consisting of increases in the total distance traveled, average distance per movement, and average speed of movement. Vertical, rotational, and stereotypic measures were not changed. Animals receiving left hemisphere lesions did not differ from sham-operated controls on any behavioral variable. The lateralized hyperactivity resulting from lesions of the right frontal cortex was confined to increased length and speed of horizontal movement and did not appear to represent a generalized increase in all components of spontaneous activity.

Animals↗
PubMed1983

A positioning fixture for L-shaped rotating undercutting microknives.

A simple, inexpensive device which controls the insertion, positioning and withdrawal of cortical undercutting microkinives is described. The device aids the "rolling" insertion of an L-shaped microknife which produces a minimum amount of overlying tissue damage while it holds the knife steady during undercutting and allows the blade to be withdrawn by way of the same track through which it was inserted.

Animals↗
PubMed1982

Intracortical kainic acid induces an asymmetrical behavioral response in the rat.

Five nanomolar doses of kainic acid injected into the right frontal cortex of rats produced a significantly greater spontaneous hyperactivity than identical injections into the left hemisphere. Hyperactivity began one week after injection and slowly continued to increase throughout the 30 day postoperative period. These results taken with our previous studies suggest that the neural asymmetry which leads to hyperactivity following right hemisphere lesions may be postsynaptic to cortical noradrenergic terminals.

Animals↗
PubMedDate not supplied

A two-year longitudinal study of post-stroke mood disorders: findings during the initial evaluation.

A consecutive series of 103 stroke patients capable of undergoing a psychiatric interview were evaluated for mood disorders. Nearly 50% of patients studied in the acute stroke period had clinically significant depressions and one fourth had symptom clusters found in major depressive disorders. We confirmed our previous findings that lesion location is most important in determining frequency and severity of depression. In addition, we have identified other variables including functional physical impairment, intellectual impairment, quality of social support, and age which contribute to or modify depression. Post-stroke depressive disorders are multifactorial in their determination and expression and include both neurophysiological-neurochemical mechanisms and psychological factors in their etiology.

Age Factors↗