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Biomedical subjects

K L Ho

Publications and source records attributed to K L Ho.

At least 91 records · Page 5Linked to original sources
PubMed1981

Concurrence of multiple sclerosis and primary intracranial neoplasms.

The concurrence of multiple sclerosis and primary intracranial neoplasms is uncommon. The literature contains 20 cases of multiple sclerosis associated with gliomas and nine cases with non-gliomatous neoplasms. This report describes a protoplasmic astrocytoma and arteriovenous malformation found incidentally at autopsy of a 63-year-old woman with a 25-year history of multiple sclerosis. This is the first demonstrated association of multiple sclerosis with an arteriovenous malformation. Although neoplastic transformation of reactive glial cells in multiple sclerosis plaques has been proposed as the source of gliomas, the association of multiple sclerosis with astrocytoma and arteriovenous malformation in the present case is considered to be coincidental. Gliomas reported in association with multiple sclerosis are more frequently (30%) multicentric than are uncomplicated gliomas.

Astrocytoma↗
PubMed1981

The medial medullary syndrome.

In a 55-year-old woman, the medial medullary syndrome developed owing to infarction of the left medullary pyramid, ventromedial portion of the inferior olivary nucleus, medial lemniscus, and hypoglossal nerve. The previously reported 14 cases of the medial medullary syndrome are reviewed, and their clinical features and topography of the medullary lesions are discussed. Like the lateral medullary syndrome, the medial medullary syndrome is closely associated with hypertension and atherosclerosis but has a higher incidence of bilateral involvement and a worse prognosis.

Brain↗
PubMed1981

Primary leptomeningeal gliomatosis: symptoms suggestive of meningitis.

Gliomas that arise primarily in the leptomeninges are rare. Of the 15 reported cases of primary leptomeningeal glioma, only two diffusely involved the leptomeninges. We report the third case of primary leptomeningeal gliomatosis, this in a 55-year-old man who died three months after the onset of symptoms. The clinical manifestations, CSF findings, and the gross appearance of the brain resembled meningitis rather than neoplasm. Results of cytologic examinations of the CSF were normal and the diagnosis was made at necropsy. The diffuse form of primary leptomeningeal glioma has a shorter clinical course and poorer prognosis than the solitary form. Primary leptomeningeal gliomas are believed to arise from heterotopic neuroglial tissue in the leptomeninges.

Brain↗
PubMed1981

A mouse model of dilated-type cardiomyopathy due to coxsackievirus B3.

Myocardial scarring was induced in 111 mice (group 3) inoculated at 14 days of age with coxsackievirus B3 and forced to swim for 30 min daily during the initial nine days of infection. The animals were observed until age 15 months. Control animals included mice infected but not forced to swim (group 2), neither infected nor forced to swim (group 1), and not infected but forced to swim (group 4). The cumulative mortality was 45% among mice in group 3 but was significantly lower in the control animals. At 15 months, mice in group 3 showed heavy deposits of calcium in the injured myocardium, atrial hypertrophy with thrombi, and myocardial fiber disintegration with replacement by fibrous scar. Mononuclear infiltration was no longer present. Pathologic changes were concentrated in the left ventricle, interventricular septum, and atrioventricular junction. Titers of type-specific neutralizing antibodies had declined to one-fifth the level present at one month. These findings represent a model of dilated-type cardiomyopathy.

Animals↗
PubMed1981

Schwannoma of the trochlear nerve. Case report.

There are only seven reported cases of intracranial schwannomas originating from the cranial nerves innervating the extraocular muscles. The present case, an incidental finding at autopsy, is the third case of schwannoma of the trochlear nerve and the first to illustrate the morphological relationship between this tumor and nerve. Reported cases of schwannoma of the oculomotor and trochlear nerves are summarized in a table.

Cranial Nerve Neoplasms↗
PubMed1980

Primary meningioma of the nasal cavity and paranasal sinuses.

A case of primary meningioma of the nasal cavity and ethmoidal sinus of a 65-year-old man is described. The clinical and pathologic characteristics of the 18 cases previously reported in the literature are reviewed. Although the histological features and biological behavior of the tumors were found to be similar to that of intracranial meningioma, primary meningiomas of the nasal cavity and paranasal sinuses were found more often to involve male patients and young individuals. Meningiomas should be considered in the differential diagnosis of any lesion in a young patient with progressive exophthalmos, nasal obstruction, or episodes of epistaxis. The pathogenesis of extracranial meningiomas is briefly discussed.

Age Factors↗
PubMed1980

Fatal spinal cord infarction caused by fibrocartilaginous embolization of the anterior spinal artery.

A fatal case of massive infarction of the cervical cord caused by fibrocartilaginous embolization of the anterior spinal artery in a 22 year old woman is reported. The source of such emboli is believed to be intervertebral disc material, but the pathogenesis of this entity is obscure. The previously reported 10 cases are reviewed and the clinical and pathological features summarized, showing that this unusual condition seems to affect females predominantly. The cervical cord is the most common site of involvement. The importance of multiple sections from various levels of the spinal cord and the application of special stains in order to determine the cause of spinal cord infarction are emphasized.

Adult↗
PubMed1980

Rhabdomyosarcoma of the trachea: first reported case.

This report describes the first case of rhabdomyosarcoma of the trachea in a 65 year old man with a five week history of cough, wheezing, and hemoptysis. The tumor, presumably originating in the submucosal tissue, was characterized as an intratracheal polypoid mass showing no local invasion or distant metastasis. Rhabdomyosarcoma of the lower respiratory tract and its histogenesis are briefly reviewed and discussed.

Humans↗
PubMed1979

Acute subdural hematoma and intracerebral hemorrhage. Rare complications of rhinocerebral mucormycosis.

Rhinocerebral mucormycosis is a short-term and often rapidly lethal fungal disease. It is generally seen in uncontrolled cases of diabetes with ketoacidosis. This case exhibits many of the features of a typical fulminating rhinocerebral mucormycosis. However, the fatal complications of acute subdural hematoma and massive intracerebral hemorrhage due to rupture of aneurysm, as demonstrated by angiography, are unique clinical manifestations of patients with rhinocerebral mucormycosis.

Antifungal Agents↗
PubMed1979

Endodermal sinus tumor of the pineal region: case report and review of literature.

This is a case report of an endodermal sinus tumor occurring in the pineal region of a 14-year-old boy who died 4 weeks after surgery and irradiation. Germ cell tumors of this type demonstrate a selective overgrowth of yolk sac endoderm associated with extraembryonic mesoblast and arise preferentially in the gonads of young children. This tumor in the pineal region is rare and carries a grave prognosis as in other extragonadal sites. A summary of previously reported cases is also presented.

Adolescent↗
PubMed1979

Sarcoidosis of urethra simulating carcinoma.

Sarcoidosis of the urethra was found during endometrial curettage in a thirty-nine-year-old woman with a history of menometrorrhagia and decreased urine stream. Sarcoidosis is known to occur in many parts of the body, but an extensive search of the literature has failed to reveal any previous report of urethral involvement.

Adult↗