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Biomedical subjects

K L Austin

Publications and source records attributed to K L Austin.

10 recordsLinked to original sources
PubMed1992

Lipid and hormonal profile of Panamanian women during the menstrual cycle.

Forty-one women of reproductive age were included in the study, to establish the variation of serum lipids during the menstrual cycle and simultaneously, to determine the physiological fluctuation of FSH, LH, prolactin (PRL), progesterone (P4) and estradiol (E2) concentration in serum, during the menstrual cycle. A significant decrease of total serum cholesterol (165.29 +/- 3.6 mg/dl) and triglycerides (108.99 +/- 9.65) occurred during the luteal phase, as compared with the follicular phase (176.16 +/- 3.51, 108.99 +/- 9.65). Changes were not observed with HDL-cholesterol during the cycle. On the other hand, FSH showed an initial rise (mean 5 IU/l) followed by a surge (10 IU/l) and a progressive fall toward the midcycle. In contrast LH secretion showed a steady increase with a maximal concentration at surge (32.1 IU/l). PRL mean value was observed, with a discrete increase after day 13 of the menstrual cycle, that was more noticeable at the end of the cycle. Forty-eight hours after the FSH and LH midcycle surge, elevation of progesterone was observed, with maximal concentration occurring on day 24 (23 nmol/l) and later on progesterone levels fell rapidly. Thirty-six to 24 h before the surge of LH and FSH at midcycle was observed the peak serum concentration of estradiol (1300 pmol/l) followed by a progressive fall. Changes in the concentration of serum lipids during the menstrual cycle are presumably due to a direct or indirect effect of physiological fluctuation of sex hormones.

Adolescent↗
PubMed1992

[The premenstrual tension syndrome. The role of molimina].

The author reviews the premenstrual syndrome, from its aetiological and physiopathological characteristics, as well as considerations in regards to its clinical manifestation and therapeutical possibilities. The concept of "molimina" and its hormonal characteristic is defined, as well as its manifestations within the PMS.

Adult↗
PubMed1979

A pharmacokinetic approach to postoperative pain: continuous infusion of pethidine.

In an attempt to improve postoperative pain management an intravenous infusion of pethidine was designed to provide stable therapeutic blood concentrations. Ten female patients undergoing elective abdominal hysterectomy were studied. After commencement of the infusion, blood pethidine concentrations increased rapidly and exceeded 0.46 microgram/ml after four hours. The mean steady-state concentration of 0.67 microgram/ml was reached by twenty-four hours. This infusion regimen resulted in the abolition of severe pain after three hours and analgesia continued for the duration of the two day study. Significant blood concentrations of the metabolite norpethidine were found although clinically no toxic effects were observed. Side effects of pethidine were infrequent. Controlled continuous intravenous infusion of pethidine produced stable blood concentrations and provided excellent pain control.

Adult↗
PubMed1979

Intensive care data--I: Computer controlled analysis.

A flexible, simple computer-controlled system for analysis of administrative and clinical data in intensive care is described. The system uses an interactive data input programme to facilitate data entry, an editor to correct errors, and the Statistical Package for the Social Sciences (SPSS) for data selection, retrieval and analysis. The system has the following features: data input is simple; large amounts of data can be handled rapidly and accurately; old data is readily available for comparison with new data and can be included in the present analysis; available statistical packages remove the need for a programmer; complex analyses are possible. The system has been successfully used for two years to provide administrative and clinical data which is pertinent to patient care.

Australia↗
PubMed1979

Intensive care data--II: A new unit's first two years.

Intensive care units now exist in a large number of hospitals. They vary from one another in many respects, but have one thing in common--high running costs. There are few published reports in recent years of the workload, results and effectiveness of intensive care units. This paper presents data obtained from a new unit in 1977 and 1978, using a computer-controlled system of data storage and analysis. This has provided useful information of an administrative and clinical nature, and has enabled us to compare data from year to year, as well as allowing comparisons with data from other units. The potential exists for such a system to be useful in evaluating criteria for admission and termination of care, and for cost-effectiveness studies.

Adolescent↗
PubMed1978

Simultaneous quantitation of morphine and paraben preservatives in morphine injectables.

A high-performance liquid chromatographic method for the simultaneous determination of morphine sulfate, methylparaben, and propylparaben in morphine sulfate injection was developed. A reversed-phase system, based on an octadecylsilane stationary phase, was used with a binary solvent mobile phase consisting of methanol--phosphate buffer (pH 4.0) containing methanol (5%) delivered at a constant rate (0.6:0.4 ml/min) using a two-pump system. The detector response at 254 nm was linear with the amount injected over a wide range, allowing rapid and reproducible quantitation of each component.

Chromatography, High Pressure Liquid↗
PubMed1977

Screening for malignant hyperpyrexia.

Skeletal muscle from normal human subjects produced linear contracture responses in vitro to caffeine at concentrations of between 4 and 32 mmol/litre. In the presence of 0.4% halothane, caffeine contractures were greater but the magnitude of halothane potentiation decreased as the caffeine concentration was increased. The contractures produced by caffeine 4 and 8 mmol/litre at 37 degrees C were significantly reduced by decreasing the temperature of the incubation solution to 25 degrees C. Among 57 normal subjects, 18% had fibres which responded to halothane treatment with contracture. On the basis of these findings, it is suggested that screening for malignant hyperpyrexia by in vitro pharmacological testing of skeletal muscle should be carried out at 37 degrees C, and should include exposure of the sample to halothane, caffeine, suxamethonium and potassium rather than to halothane alone.

Caffeine↗
PubMed1977

Drug treatment of malignant hyperpyrexia.

Of the various drugs currently suggested for the treatment of malignant hyperpyrexia, dantrolene sodium was the most effective in reversing and inhibiting drug induced contractures in vitro, both in normal muscle and in muscle from patients who are susceptible to malignant hyperpyrexia. It is suggested that dantrolene sodium is the drug of choice for lowering the raised myoplasmic calcium concentrations in malignant hyperpyrexia.

Caffeine↗
PubMed1975

Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor.

We conducted a double-blind study to determine the efficacy of 17alpha-hydroxyprogesterone caproate in preventing premature delivery in 43 high-risk patients. Premature delivery did not occur in 18 patients receiving the progestational agent, whereas 41 per cent of the 22 receiving the palcebo had premature delivery (P less than 0.01). The mean duration of pregnancy and the mean birth weight in the former group (38.6 weeks +/- 1.6 S.D., and 2836 g +/- 412 S.D.) were both significantly greater (P less than 0.025) than that in the latter (35.2 weeks +/- 6.7 S.D.; 2361 g +/- 1085 S.D.). The perinatal mortality rate in the group given the progestational agent (O per cent) was significantly less than that observed in the placebo group (27 per cent) (P less than 0.05). Although there were no complications attributable to the progestational drug, the study population was too small for assessment of immediate or long term safety. However, the results indicate a possible obstetric use for this drug.

Adult↗