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Biomedical subjects

K Kuzuhara

Publications and source records attributed to K Kuzuhara.

At least 37 records · Page 2Linked to original sources
PubMed1993

In vivo examination of the dynamic properties of the human heel pad.

The shock-absorbing characteristics of the heel pad in vivo were examined in adults (N = 16) and 7-year-old children (N = 5) using a drop-impact tester (wt = 5 kg). Impact velocities were 0.72 m/s and 0.93 m/s. It was found that in adults the average peak deceleration was 11.6 G at an impact velocity of 0.93 m/s. The maximum deformation of the heel pad was 11.3 mm, and the computed energy absorption during impact amounted to 79% (range = 75%-89%). These mechanical characteristics remained nearly the same even after 6 min of repeated impacts by the impact tester and even after a 10 km run. The children had larger values of peak deceleration and maximum deformation and smaller energy loss than the adults. It was concluded that the heel pad was a fairly effective shock attenuator and high energy absorber, and that these characteristics remain nearly unchanged even after a relatively long period of repeated impacts. It was also concluded that the mechanical properties of the children's heel pads were different from those of the adults.

Acceleration↗
PubMed1993

[The clinical significance of albuminuria in renal transplantation].

Urinary excretion of albumin was measured after renal transplantation in 37 patients who received cyclosporine quadrotherapy (cyclosporine A, azathioprine, prednisolone and antilymphocytoglobulin). In 26 patients with a favorable clinical course, daily urinary albumin level increased significantly on the first operative day. Subsequently, it decreased gradually, and remained at about 40mg/day after 3 weeks. In these patients, the urinary albumin level did not correlate with blood pressure, whole blood cyclosporine level, serum creatinine level nor urinary enzyme level, i.e. beta 2-microglobulin, NAG, gamma-GTP. As for correlation between the urinary albumin level and biopsy findings in 21 patients who underwent renal graft biopsy, the urinary albumin level was significantly increased in 5 patients with high degree of lymphocyte infiltration in the renal graft as compared with 16 patients with low degree of infiltration. However, there was no significant correlation between the urinary albumin level and the degree of tubular damage. In 4 patients of allograft rejection, a clinical course was reflected better in the albumin level than in the urinary enzyme level, these results show that the measurement of urinary albumin is a useful clinical examination to evaluate the allograft rejection of renal transplantation in cyclosporine era.

Albuminuria↗
PubMed1987

Acute changes in C3a and C5a in an anaphylactoid reaction in hemodialysis patients.

Blood sample were collected from both the arterial and venous lines of the patients undergoing hemodialysis using cuprophan membrane at several time intervals. Radioimmunoassay was then applied to measure the C3a and C5a levels. C3a levels from the arterial lines of patients undergoing uneventful hemodialysis were 463.2 +/- 51.3 ng/ml (mean +/- S.D.), 1112.9 +/- 109.9, 956.0 +/- 72.1, and 721.2 +/- 49.6 at 0, 15, 120 and 360 min, respectively. C5a levels did not change significantly during uneventful hemodialysis. C3a and C5a levels were significantly higher in the blood from the venous lines than those from the arterial lines, a finding indicating that complement activation via alternative pathway takes place in the dialyzer. C3a and C5a levels were markedly elevated in patients with anaphylactoid reaction. Reuses of dialyzers on the patients having a history of an anaphylactoid reaction during hemodialysis suppressed not only the rise of C3a levels, but also the recurrence of the reaction. From these findings, it is concluded that rises of C3a and C5a in the arterial lines of patients are causally related to the induction of anaphylactoid reaction during hemodialysis.

Anaphylaxis↗