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Biomedical subjects

K Kuwabara

Publications and source records attributed to K Kuwabara.

107 records · Page 6Linked to original sources
PubMed1979

Levels of organochlorine pesticides and polychlorinated biphenyls (PCBs) in mothers' milk collected in Osaka Prefecture from 1969 to 1976.

Long-term investigations of polychlorinated hydrocarbon levels in mothers' milk were made from 1969 to 1976. The levels of p,p'-DDE, p,p'-DDT, dieldrin and PCB in mothers' milk were within the range reported by others. However, beta-BHC(Hexachlorocyclohexane) levels in the milk were 10 times that found in non-Japanese. A gradual decrease in the beta-BHC level in the milk was observed during this period. In contrast, the levels of p,p'-DDE, p,p'-DDT, dieldrin and PCB were consistent for the 7-year period. A significant correlation between the levels of PCB and p,p'-DDE in mothers' milk and blood was observed in the 1974-1976 samples. However, after prohibition of the use of chlorinated hydrocarbons, this relationship was less apparent in the 1972-1973 samples.

Female↗
PubMed1979

Surveillance of the daily PCB intake from diet of Japanese women from 1972 through 1976.

A survey of the daily PCB intake from the total diet of Japanese women was made for the years 1972 through 1976. All but one sample of 177 samples analyzed were contaminated with PCBs. Only one sample exceeded the acceptable daily intake (ADI) of PCBs of 5 micrograms/kg body weight in Japan. The average daily intake of PCBs per person was approximately 10 micrograms, which was very low compared to the ADI value. The main source of PCBs in the diet in Japan was inshore fishes, in contrast to fresh water fishes as in the U.S.A. The data obtained from this surveillance showed no statistically significant change of daily PCB intake from the diet during this 5-year period. However, there has been a marked decrease in the estimated intake of PCBs since 1972. Gas chromatograph analysis of the residual PCB patterns in the diet showed that the patterns in the marine products were somewhat different from those in dairy, meat, and poultry products. The former was similar to the pattern of the PCB standards mixture and the latter was similar to the PCB pattern found in human milk and tissue samples from the Japanese population.

Adult↗
PubMed1978

Identification of low chlorinated biphenyls in human milk by gas chromatography--mass spectrometry.

Trichlorobiphenyl and tetrachlorobiphenyls in human milk were analysed by gas chromatography--mass spectrometry and mass fragmentography using silicone OV-1 and Apiezon L grease as stationary phases. Low-chlorinated biphenyls had been considered to be excreted rapidly from the body, but in this work quantities of tri- and tetrachlorobiphenyls amounting to approximately 30% of the total of polychlorinated biphenyls (PCBs) accumulated in the milk were identified. This result is important in relation to the quantification of PCBs and in studies of the mechanism of biological degradation.

Chromatography, Gas↗
PubMedDate not supplied

Postnatal transfer of PCBs from exposed mothers to their babies: influence of breast-feeding.

Polychlorinated biphenyl (PCB) concentrations in the blood of mothers who were occupationally exposed to PCBs in a capacitor manufacturing facility, and their children, were analyzed from 1975 to 1979. The factory terminated PCB use in 1972, and environmental PCBs were eliminated artificially. Despite this, blood PCB levels of the mothers were very high, i.e., 10-100 times higher than that of non-occupationally exposed persons. In a previous report, we discussed the relationship between breast-feeding and PCB levels in the blood. This relationship is confirmed further by the present investigation which continued during a 5-yr period. The PCB levels in blood of children were influenced greatly by the duration of breast-feeding, but showed little relationship to the PCB levels in maternal blood. The PCB exposure period of the mothers, time of birth, and age of the children were less clearly related to the PCB levels in the children. The PCB concentration in the children's blood decreased at a constant rate and was independent of their blood PCB levels. A similar result was noted for their mothers' PCB levels. A slight difference, however, was found in the rate of decrease of blood PCB levels between the mothers and children. The results of questionnaire research on the health conditions and the medical examinations for the children showed that frequency of complaints, e.g., red eye, fever, itchy skin, and carious teeth, related favorably to the duration of breast-feeding. Less severe findings, i.e., decay of nails, pigmentation, mottled enamel, carious teeth, which were typical symptoms in yusho patients, were observed in some children. They were not, however, diagnosed as having PCB poisoning inasmuch as medical treatments were unnecessary.

Breast Feeding↗