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Biomedical subjects

K Kusakabe

Publications and source records attributed to K Kusakabe.

150 records · Page 9Linked to original sources
PubMedDate not supplied

Myocardial dysfunction and depressed fatty acid metabolism in patients with cyanotic congenital heart disease.

BACKGROUND: Myocardial contractile dysfunction has been frequently observed in adolescents or adults with cyanotic congenital heart disease. Impaired energy metabolism may be present in such dysfunctional myocardium. METHODS AND RESULTS: To evaluate the findings of myocardial free fatty acid metabolism, and its relations to ventricular wall motion and myocardial perfusion in cyanotic congenital heart disease, we performed a combined study of iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) scintigraphy, thallium scintigraphy, and contrast cine-angiography in seven patients with single right or left ventricle. The results showed that wall motion was reduced in 17 of 35 ventricular segments (49%), which were mostly identical in location to decreased BMIPP uptake. The severity of BMIPP uptake deficit correlated positively with the degree of impairment of wall motion. On the other hand, thallium uptake was abnormal only in 5 of 35 segments (14%), and the severity of the perfusion defect did not correlate with the degree of wall motion abnormality. CONCLUSIONS: Contractile dysfunction in cyanotic heart disease was primarily linked to impaired free fatty acid metabolism rather than to myocardial scar as represented by perfusion defect on thallium imaging.

Adolescent↗
PubMedDate not supplied

A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and alpha-methyl-p-tyrosine.

A 47-year-old man had surgery for paraaortic paraganglioma in 1980 and 1985. In 1987, his urinary excretion of catecholamines and metabolites was extremely high. Scintigraphy with 131I-metaiodobenzylguanidine (MIBG) showed multiple bone and liver metastases. He was treated twice with infusions of 3.7 GBq of 131I-MIBG. After the first treatment, he had transient hypertension and pain in the back and right leg. Subsequent 131I-MIBG scintigraphy showed that the number of metastatic tumors had decreased. The second treatment was less effective. Excess catecholamines were treated with alpha-methyl-p-tyrosine (MPT), a catecholamine synthesis inhibitor, at doses between 250 and 2000 mg/day, which significantly decreased urinary NE excretion. This is the first case treated with 131I-MIBG in Japan.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Study report--clinical application of Ga-67 DFO-DAS-fibrinogen.

The purpose of this study was to apply a new radiopharmaceutical for thrombus imaging. Forty patients with thrombus, including 18 with aortic aneurysm and seven with graft replacement, were studied using the planar imaging technique. Thrombus imagings were obtained 6-96 hours after intravenous administration of 2 mCi of 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen). The best images were achieved 48-96 hours after 67Ga-fibrinogen administration. Twenty-one of 40 patients with proven thrombus had positive planar images. A high positive ratio (83%) was obtained in patients with aortic aneurysm. In the remaining patients, the planar images were interpreted as showing no evidence of active thrombus formation of fibrinogen. These studies demonstrate the potential of 67Ga-fibrinogen for the noninvasive localization of active thrombi.

Adult↗