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Biomedical subjects

K Kuroda

Publications and source records attributed to K Kuroda.

At least 325 records · Page 18Linked to original sources
PubMed1989

[Clinical results of endourologic technique for upper urinary calculi].

Between May, 1985 and September, 1987, percutaneous nephrolithotripsy (PNL) and transurethral ureterolithotripsy (TUL) have been performed at our hospital and five affiliated hospitals. We report on the therapeutic results of 216 cases treated during this period. PNL and TUL were performed 168 times on 120 patients (119 males and 41 females) and 57 times on 56 patients (35 males and 21 females), respectively. Rate of success with PNL was 80.7% (103/130) for renal calculus, 85.7% (18/21) for upper ureteral calculus, and 47.1% (8/17) for middle-lower ureteral calculus. Rate of success with TUL was 57.9% (33/57). Of these, cases of ureteral lower edge calculus showed the lowest rate of success, being 33.3% (2/6). Complications of the cases undergoing PNL and TUL were: ureteral damage in 13; hemorrhage in 6; renal pelvic damage in 4; ureteral lower edge stenosis in 3; pyrexia in 3; cardiac insufficiency in 2 and retention of perfusate in posterior peritoneal cavity, pneumonia and renal insufficiency in 1 case each.

Adolescent↗
PubMed1989

[Hepatic artery and portal vein infusion of adriamycin in experimental liver metastasis].

Hepatic artery and portal vein infusion of adriamycin (ADM) to normal rabbit and the experimental liver metastasis model of VX2 tumor were discussed in this study. The concentration of ADM in the peripheral blood, liver, myocardium, lung of normal rabbit and metastatic tumor were measured in the HPLC method. There was no difference between arterial infusion and portal infusion in the normal rabbits. In the metastatic tumor, one hour after the infusion, concentration of ADM showed no difference between arterial and portal infusion, but two and three hours later, the concentration was significantly higher after portal infusion than arterial infusion. It was suspected that portal infusion would be more effective for liver metastasis. The number of tumor nodules for estimation of the anti-tumor effect on metastatic models was decreased significantly after arterial and portal infusion compared with the controls, but there was no statistical difference between arterial and portal infusion.

Animals↗
PubMed1989

[A case of exostosis based on the left first rib].

Exostosis of the rib is uncommon, especially in the prime of manhood. A 51-year-old man came to our hospital with coin lesion in his left apical region, revealed on routine chest X-ray film. Thoracotomy was done to remove the tumor and the histological diagnosis was exostosis. The tumor, 18 by 18 mm in size, was based on the first rib and grew into the thoracic cavity.

Bone Neoplasms↗
PubMed1988

Characterization of a pantropic variant of Sendai virus derived from a host range mutant.

A variant (F1-R) was isolated from a temperature-sensitive host range mutant (ts-f1) of Sendai virus. F1-R was no longer temperature-sensitive but it retained the host range phenotype. Unlike wild-type virus, F1-R and ts-f1 undergo multiple cycles of replication in several cell lines in the absence of trypsin. This was attributed to proteolytic activation of the fusion (F) glycoprotein of the host range mutants, in cell nonpermissive to wild-type virus. In mice infected intranasally the variant F1-R caused a generalized infection. This was shown by immunohistology and with infectious virus being recovered from several organs whereas infection with wild-type virus was restricted to the lung. These observations indicate that the pantropic property of F1-R is the result of proteolytic activation of the virus by ubiquitous proteases. Nucleotide sequence analyses revealed that ts-f1 and F1-R differed from the wild-type virus by mutations at the region of the cleavage site of F and at the glycosylation site of the F2 subunit. The findings indicated that these mutations are responsible for the increased cleavability of the F protein of ts-f1 and F1-R and therefore are important determinants for the pantropism of F1-R.

Animals↗
PubMed1988

Preparation of tubulin from Caulerpa, a marine green alga, using casein as a protective agent against proteolytic degradation.

Bidirectional organelle movements taking place in the cytoplasm of the rhizomes of Caulerpa, a coenocytic marine green alga, have been indicated to be dependent on microtubules (Kuroda, K. & Manabe, E. (1983) Proc. Jpn. Acad. 59B, 131-134; Manabe, E. & Kuroda, K. (1984) Proc. Jpn. Acad. 60B, 118-121). However, when a crude extract of Caulerpa rhizomes was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and subjected to immunoblotting with monoclonal anti-tubulin antibody, no reacting band could be detected. This apparent absence of tubulin in the extract was found to be a result of the complete degradation of tubulin by potent intrinsic proteolytic activity. All of the commercially available protease inhibitors so far tested (p-chloromercuriphenylsulfonic acid, phenyl methylsulfonyl fluoride, 1-chloro-4-phenyl-3-tosylamido-2-butanone, 7-amino-1-chloro-3-tosylamido-2-heptanone, p-tosyl-L-arginine methyl ester, soybean trypsin inhibitor, antipain, chymostatin, leupeptin, and pepstatin) failed to inhibit the activity completely. But addition of casein at the concentration of 1% (weight per volume) to the solutions used for preparation was effective in protecting tubulin from proteolytic degradation, thus making it possible to prepare tubulin from the crude extract of Caulerpa. On SDS-PAGE, the Caulerpa alpha-tubulin thus prepared was a little smaller in molecular weight than that of rabbit brain.

Animals↗
PubMed1988

Total venous obstruction--a possible complication of transvenous dual-chamber pacing.

Transvenous endocardial pacing has been widely accepted as an effective means to treat patients with bradycardia, though there are some complications unique to this approach. For example, occlusion of the major vessels can be induced by the presence of a single pacing electrode, though it is an extremely rare occurrence. In this paper, we describe 2 cases of venous obstruction complications caused by dual-chamber pacemaker implantation. Venographic studies were useful to confirm the diagnosis, and immediate anticoagulant therapy resulted in a good course. It is speculated that this phenomenon will increase as physiological, dual-chamber pacing becomes more widely performed. Physicians must pay careful attention to the complication of venous obstruction when managing patients with implanted transvenous dual-chamber pacemakers.

Aged↗
PubMed1988

[Cystitis in 8 patients treated with tranilast].

We encountered 8 cases of cystitis probably caused by Tranilast. Bladder biopsy performed on 6 of the 8 cases revealed eosinophilic cystitis in 3 cases. In the lymphocyte stimulation test using Tranilast as an antigen, a positive and false positive reaction was seen in one case each. This disease seemed to occur as a result of allergy of the bladder specific to Tranilast.

Adult↗
PubMed1988

Fatal Yersinia enterocolitica septicemia complicated by unique hemosiderosis. A case report.

A fatal case of Yersinia enterocolitica septicemia which was complicated by unique hemosiderosis is reported. On admission, the patient had diabetes and showed unusual hyperferritinemia. Postmortem examination revealed that the liver was studied with abscesses, and Yersinia antigen was expressed in foamy macrophages within these abscesses. Moreover, the cadaver showed generalized hemosiderin deposition, which was mainly observed in the liver and, to lesser degrees, in the pancreas, spleen, lymph nodes, brain, thyroid and kidneys. Since there was no apparent cause of the hyperferritinemia and generalized hemosiderosis, consideration was given to possible primary hemochromatosis. However, no liver or pancreatic fibrosis was demonstrated. Kupffer cells were also loaded with hemosiderin, and therefore it was considered that these cells had lost their ability to phagocytize the microorganism adequately, leading to major liver involvement. Interestingly, hemosiderin deposits in the kidneys were mostly present in glomerular epithelial cells. To our knowledge, this unique presentation has not been previously described in humans.

Adult↗
PubMed1988

[Considerations in determining indication for valvular surgery].

Between 1970 and 1987 valvular operations with cardiopulmonary bypass were performed on 636 patients, with an overall early mortality of 7.5%. To determine the critical indication for valvular surgery, preoperative clinical characteristics were examined by comparing 35 patients, who had died of surgery because of low cardiac output syndrome or multiple organ failure, with operative survivors. The multivariable logistic analyses demonstrated that NYHA functional class IV, multiple valvular disease, large CTR more than 70%, high left ventricular end-diastolic pressure more than 15 mmHg, depressed left ventricular ejection fraction less than 40%, and renal and hepatic dysfunction were powerful independent clinical characteristics concerning operative mortality. The mortality was highly significant when a patient was associated with more than three of the above factors in addition to being NYHA class IV. It should be emphasized, however, that there are three survivors among 11 patients with all six factors. On the other hand the prognosis of such patients without surgery was very poor, fifteen of 21 patients, medically treated during the same period, died within two years after reaching NYHA class IV condition. These results show that several predictors are useful for decision making regarding the indication for valvular surgery. Surgery, however, should not be denied because of the severity of the disease.

Heart Valve Diseases↗
PubMed1988

Efficient oligoadenylate synthesis catalyzed by uranyl ion complex in aqueous solution.

Polymerization of adenosine-5'-phosphorimidazolide in an aqueous solution was conducted with uranyl ion as a catalyst. Oligoadenylate formation took place efficiently with high regio-selectivity (2'-5' linkage). The oligoadenylates up to hexadecamer were obtained in a high total yield. The chain length and the regio-selectivity of the resulting oligoadenylates varied greatly depending on the concentration of the uranyl ion catalyst. The oligonucleotide formation is likely to be mediated by uranylnucleotide complex.

Adenine Nucleotides↗
PubMed1988

Effects of cadralazine on systemic blood pressure, renal function and plasma renin activity in anesthetized dogs.

Renal effects of ethyl 6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinecarbazate (cadralazine), a newly synthesized vasodilator with a pyridazine ring, were studied in anesthetized dogs. 30 min after intravenous (i.v.) injection of cadralazine in a dose of 1 mg/kg diastolic blood pressure (DBP) decreased from the control value of 115 +/- 4 mmHg to 108 +/- 3 mmHg. The decrease continued, being accompanied by an increase in heart rate, throughout the experimental period of 5 h. Renal vascular resistance was decreased significantly, while glomerular filtration rate and urine volume remained unchanged. Urinary excretions of sodium and potassium were increased about 1.5 to 2 times as compared to pre-injection control values. Hypotension and natriuresis were followed by increased plasma renin activity in the artery or renal vein. On the other hand, i.v. injection of hydralazine (0.3 mg/kg) promptly decreased DBP and urinary sodium excretion, 15 min after administration, with blood pressure tending to revert to the control value. These results indicate that cadralazine has hypotensive and renal vasodilating actions, characterized by a slow onset and long duration, when compared with hydralazine.

Anesthesia↗
PubMed1988

Veno-occlusive disease of the liver in a patient with allergic granulomatous angiitis.

A 45-yr-old woman, with asthma and skin erythema, was diagnosed as having allergic granulomatous angiitis. Leukocytosis accompanied by hypereosinophilia and characteristic histological findings of skin lesions also were present. Upon laparoscopy and liver biopsy, the liver showed a congestive appearance and, histologically, showed thickening of the central vein walls, as well as narrowing of the lumens with collagenous fibers, and pericentral hemorrhage with hepatocyte degeneration. A diagnosis of veno-occlusive disease of the liver was made. This is the first report on a case of veno-occlusive disease of the liver occurring in association with allergic granulomatous angiitis.

Female↗