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Biomedical subjects

K Kurisu

Publications and source records attributed to K Kurisu.

318 records · Page 18Linked to original sources
PubMedDate not supplied

Subtracted 3D CT angiography for evaluation of internal carotid artery aneurysms: comparison with conventional digital subtraction angiography.

BACKGROUND AND PURPOSE: 3D computed tomographic angiography (3DCTA) has been used recently for the evaluation of intracerebral aneurysms, but it is difficult to use this technique to visualize aneurysms near the base of the skull because of the presence of bone. Subtracted 3DCTA could replace digital subtraction angiography (DSA) for evaluation of aneurysms near the base of the skull if the 2 methods were to give similar results. The aim of this study was to compare the evaluation of aneurysms of the internal carotid artery (ICA) near the base of the skull by subtracted 3DCTA and DSA. METHODS: CTA and DSA were obtained in 25 patients with unruptured aneurysms of the ICA. To create subtracted 3DCTA images, we used a volume subtraction (VS) method, wherein nonenhanced volume data are subtracted from enhanced volume data. CTA and DSA were reviewed by 2 neuroradiologists who performed the detection and characterization of aneurysms of the ICA by using 2D multiplanar reformatted (MPR) and VS- and nonsubtracted (NS)-3DCTA images with volume rendering techniques. RESULTS: DSA detected 29 aneurysms in the 25 patients. VS-3DCTA detected all 29 aneurysms in the 25 patients and was equivalent to DSA for evaluating their characteristics (location, size, and direction). NS-3DCTA detected 19 (1 cavernous, 4 ophthalmic, 1 superior hypophyseal, 7 posterior communicating, and 6 anterior choroidal artery) of these 29 aneurysms, but it could not characterize ophthalmic and superior hypophyseal artery aneurysms because they were only partly visible on NS-3DCTA because of bony structures. 2D-MPR images detected all but the small aneurysms (24 of 29 detected). VS-3DCTA and 2D-MPR could visualize all branching arteries (ophthalmic, posterior communicating, and anterior choroidal) detected by DSA, but NS-3DCTA could not visualize ophthalmic arteries because of the presence of bony structures. CONCLUSION: VS-3DCTA can be used as an alternative to DSA for preoperative examination of aneurysms near the skull base, where it provides equivalent identification and characterization.

Adult↗
PubMedDate not supplied

Osteosarcoma following radiotherapy: a case report.

The case of a patient with postirradiation osteosarcoma is presented. The 20-year-old female was diagnosed as having osteosarcoma by histological examination of an open biopsy specimen. She underwent surgery for pure dysgerminoma and received adjuvant postoperative radiotherapy, 40 Gy to the pelvis and 30 Gy to the para-aortic region, 11 years ago. This case satisfied the criteria for radiation-induced osteosarcoma proposed by Cahan et al. Radiation-induced osteosarcoma is rare, but the possibility of that must be borne in mind.

Adult↗
PubMedDate not supplied

High-dose-rate intraluminal brachytherapy for postoperative residual tumor of gallbladder carcinoma: a case report.

The case of a patient with gallbladder carcinoma who had a postoperative residual tumor treated with high-dose-rate intraluminal brachytherapy (HDRIBT) and external radiotherapy (ERT) is presented. HDRIBT (20 Gy/2 fr) was performed at one point 10 mm from the 60Co source on 27 and 34 days after simple cholecystectomy. ERT (30 Gy/15 fr) was also given two weeks after HDRIBT. Following radiotherapy, she has been alive and well without signs of recurrence for one year and ten months as of this writing. HDRIBT combined with ERT is recommended for the treatment of post-operative residual tumors of advanced gallbladder carcinomas.

Adenocarcinoma↗
PubMedDate not supplied

Aneurysmal bone cyst treated by high-energy, low-dose radiation therapy: a case report.

Aneurysmal bone cysts (ABC) are frequently treated surgically, but recurrence is not uncommon and surgery is hazardous when the lesion is large and adjacent to the growth plate. High-energy, low-dose radiation to an 8-year-old girl with ABC of the distal tibia was found to be successful, with no recurrence during the five-year follow up. No complications have ensued, and excellent function has been sustained. Further evaluation of this radiation treatment is important for similar situations in which surgical excision of ABC may involve high risk.

Bone Cysts↗
PubMedDate not supplied

Primary rectal cancer treated with high-dose-rate intraluminal brachytherapy following external radiotherapy.

An 80-year-old man with rectal cancer who had diabetes and angina was treated with high-dose-rate intraluminal brachytherapy (30 Gy) following external radiotherapy (30 Gy). After this treatment, anal pain and bleeding improved greatly, and he was able to evacuate the bowels. However, the endoscopic biopsy taken five months after treatment revealed active cancer cells.

Adenocarcinoma↗
PubMedDate not supplied

Total lymphoid irradiation and total body irradiation for allogeneic bone marrow transplantation in aplastic anemia.

Between April 1980 and June 1989, 15 patients with severe aplastic anemia (SAA) were treated at Hyogo College of Medicine with bone marrow transplantation (BMT) after preparation consisting of cyclophosphamide (CY) and total lymphoid irradiation (TLI) or total body irradiation (TBI) for the purpose of reducing the incidence of graft rejection. All patients had initial evidence of engraftment after the first transplantation except for one patient who died of heart failure due to CY on the third day after transplantation and could not be evaluated for engraftment. Rejection later occurred in four of these 14 patients, who then underwent successful regrafting. One of these patients, who was conditioned with CY alone at the first grafting, underwent successful regrafting after a conditioning regimen of CY and TBI. In the other three patients, irradiation was performed twice as the conditioning regimen. Thus, 14 of 15 patients underwent successful BMT and are alive with restored hematopoietic function. From the above results, the combination of TLI or TBI and CY was considered to be very useful as a conditioning regimen for BMT in patients with SAA.

Adolescent↗
PubMedDate not supplied

Inhibitory effect of TNP-470, a new anti-angiogenic agent, on the estrogen induced rat pituitary tumors.

An angiogenic inhibitor, TNP-470, is an analogue of fumagillin. This study reports the effects of TNP-470 and bromocriptine on the normal pituitary glands and estrogen-induced rat pituitary tumors. TNP-470 inhibited the increase of normal pituitary weight and the tumorigenesis induced by estrogen. The decreased labelling index in the pituitary cells, showed that TNP-470 may suppress the activity of cell proliferation as the result of anti-angiogenesis. Combination treatment with TNP-470 and bromocriptine was much more effective than TNP alone. These results suggest that TNP-470 is a potentially beneficial drug for pituitary tumors.

Animals↗
PubMedDate not supplied

Effects of pump flow rate on oxygen use during moderate hypothermic cardiopulmonary bypass.

The authors investigated the effects of pump flow rate on oxygen use during a moderate hypothermic cardiopulmonary bypass (CPB) in 31 patients during either coronary artery bypass grafting or valve replacement and aortic cross clamping. Intravenous anesthesia was performed with high dose fentanyl. A neuromuscular blockade was achieved with an intravenous infusion of pancuronium. After a stable rectal temperature of 29 degrees C was obtained by both surface cooling with a blanket and core cooling with CPB, the pump flow rate was changed from 2.4 L/min/m2 to 2.2, 2.0, 1.8 and 1.6, keeping the same flow rate for at least 5 min. Both arterial and venous blood was sampled for blood gas analysis; serum lactate measurement and hemodynamic changes were monitored and recorded at each flow rate. In 10 of 31 patients, whose aortic cross clamping time was longer than 90 min, the same measurements were followed 10 min after the induction of prostaglandin E1 (PGE1) (40 +/- 13 ng/kg/min) at pump flow rates of 2.4, 2.0, and 1.6 L/min/m2. Oxygen consumption significantly decreased at 1.6 L/min/m2 compared to the other flow rates (52.4 +/- 13.6, 54.3 +/- 11.8, 56.4 +/- 14.7, and 56.7 +/- 11.0 ml/min/m2, at flow rates of 2.4, 2.2, 2.0 and 1.8 L/min/m2, respectively, versus 48.4 +/- 10.9 ml/min/m2, at 1.6 L/min/m2, p < 0.01, paired t-test). After the induction of PGE1, both aortic pressure and systemic vascular resistance decreased significantly (p < 0.01, paired t-test) at flow rates of 2.0 and 1.6 L/min/m2.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Antitumor effect of TNP-470 on glial tumors transplanted in rats.

Anti-angiogenic agents were be clinically useful for the therapy of solid tumors, as the growth and proliferation of tumors require neovascularization. Previous reports have been made on the antitumor effect of TNP-470, an angiogenic inhibitor, on medulloblastomas implanted subcutaneously into nude mice. The present study was undertaken for the purpose of investigating possible antitumor effects on two model subcutaneous and intracranial tumors transplanted into rats. 9-L gliosarcomas were transplanted into the left femoral region subcutaneously and the left frontal region of Fisher 344 female rats, and the TNP-470 was then administered subcutaneously. The rats were divided into two treatment groups and a control group. TNP-470 resulted in dose-dependent inhibition of 9-L gliosarcoma growth and also prolonged survival in treatment groups. Therefore TNP-470 was considered to be effective for the treatment of malignant brain tumors, although it caused dose-dependent decreases in body weight.

Animals↗
PubMedDate not supplied

Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation.

We examined the genomic status of the p16 gene in 5 human glioma cell lines by Southern blot analysis. The p16 gene was located in the 9p21 chromosomal region and homozygous deletion was detected in 4 of 5 (80%) human glioma cell lines and 5 of 15 (33%) clinical samples. We transfected the full-length human p16 gene into p16-null human glioma cell line, U251MG cells, using the plasmid vector pRc/CMV-p16 and evaluated the effect of p16 gene transfer on the growth suppression of malignant glioma cells. The transfection of p16 cDNA caused growth suppression through G1 cell cycle arrest in U251MG cells. We also examined the effect of p16 gene transfer on the chemosensitivity to cis-diamminedichloroplatinum II (CDDP), 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl) -3-nitrosourea hydrochloride (ACNU), and 5'-azacytidine (AZC). We did not detect any change in them after p16 gene transfer. These results might suggest that deletion of p16 genes promoted unrestrained growth in human glioma but has no relationship to the chemosensitivity to CDDP, ACNU and AZC.

Antineoplastic Agents↗