[Determination of the approximate value of the glomerular filtration by the method of indirect radioisotope clearance].
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Biomedical subjects
Publications and source records attributed to K Kupka.
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Mass-treatment campaigns against trachoma and seasonal conjunctivitis, using chlortetracycline ointment, were started in 1952 in parts of southern Morocco. This paper reports the results of a survey carried out between 1962 and 1965, under the auspices of the Moroccan Government, WHO and UNICEF, to evaluate the effects of the mass-campaign.The survey assessed the prevalence, gravity and frequency of complications of trachoma by ophthalmological examinations, conducted in the home, and the results are compared with data published elsewhere which were obtained before treatment started in the 1950s in parts of the study area. Additional studies were made of the relation between trachoma and the availability and use of water, and between the prevalence of trachoma in females and their exposure to infection.The over-all prevalence of trachoma was unaffected by the mass-treatment campaign but a larger proportion of the cases were at stage IV of the disease (healed). In one region, however, the prevalence of active cases (stages I-III) in the younger age-groups had decreased considerably. The occurrence of pannus decreased and while trichiasis decreased in children under 15 years of age, its prevalence increased in adults. This result may be important in planning future mass-campaigns.
It has been noted in many parts of the world that bacterial conjunctivitis is a major cause of total or partial loss of vision. In addition, trachoma is aggravated if there are associated bacterial infections and these lead to more frequent corneal complications.In the trials described the seasonal variation of bacterial infections was studied in addition to trachoma in 3 pilot sectors in southern Morocco. The frequency of complications and late sequelae from these infections in the whole population of these sectors was also studied.In one of the sectors 3 different methods of limiting the regular seasonal increase in bacterial infections and of curing trachoma were evaluated separately or in combination. These included the effect of fly-suppression on the transmission of infection, a possible method of chemoprophylaxis, and intermittent treatment with chlortetracycline ointment.The effect of the latter, when applied to a whole population group by auxiliary personnel, was compared with the long-term effect of self-treatment, in this and the two other sectors.The total observation period covered 12 years.