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Biomedical subjects

K Kuokkanen

Publications and source records attributed to K Kuokkanen.

At least 37 records · Page 2Linked to original sources
PubMed1983

Hyperkeratosis lenticularis perstans (Flegel's disease).

A 62-year-old female with a 20-year history of small horny papules on the skin of the legs is described. Light microscopy revealed a hyperkeratotic papule with atrophic epidermis and a dense dermal inflammatory cell infiltrate with many cerebriform lymphocytes not earlier described in connection with hyperkeratosis lenticularis perstans (HLP). The electron-microscopic picture showed membrane-coating granules (MCG) and keratohyalin located in different cells, indicating that the disorder of keratinization in HLP is possibly caused by reduced co-operation between these cells and that the keratinization process occurs in the absence of MCG. Perpetual treatment with oral retinoid was successful.

Female↗
PubMed1982

Lymphoma in dermatitis herpetiformis: report on four cases.

Four patients suffering from protracted dermatitis herpetiformis (DH) developed lymphomas while undergoing gluten-free diet treatment. This had lasted between 6 months and 4 years. The first patient died of histiocytic lymphoma involving mesenterial lymph nodes, liver, spleen and blood marrow. The second patient died of histiocytic lymphoma disseminated in the ileum, colon, stomach and mesenterium. This patient had been operated on 14 years earlier for a solitary ulcerating lymphoma in the ileum. The third patient had a localized histiocytic lymphoma in the colon. This was successfully removed by hemicholectomy. The fourth patient had a lymphocytic lymphoma of B-cell origin in the inguinal lymph nodes which was treated with radiotherapy. These 4 patients with lymphomas suggest that, like coeliac disease patients, DH patients also run an increased risk of developing lymphomas.

Adult↗
PubMed1980

Evaluation of delayed type immune reactivity in patients with acne vulgaris.

The delayed-type immune reactivities of 39 patients suffering from moderate to severe papulopustular or nodulo-cystic forms of Acne vulgaris were compared with healthy acne-free controls. In vivo reactivity was assessed by skin testing with four common recall antigens. In vitro the afferent arm of the immune system was assayed by antigen and mitogen simulated lymphocyte transformation and the efferent arm by granulocyte random migration and by granulocyte responsiveness to a standard migration inhibitory lymphokine preparation. Spontaneous lymphocyte transformations were also evaluated. In acne patients the skin test reactivities were in general only slightly decreased. Their lymphocytes showed relatively normal responses to mitogen stimulation, but antigen responsiveness was significantly diminished. Furthermore the patients' lymphocytes showed increased spontaneous transformation. All these changes correlated, to some extent, with the severity of the disease. The granulocytes of acne patients showed increased random migration, of borderline significance, but the granulocyte responses to the lymphokine preparation were completely normal. The results suggest that immunologic abnormalities are mild and probably secondary to the inflammatory process.

Acne Vulgaris↗
PubMed1979

Antihypertensive effect of prazosin in combination with methyldopa, clonidine, or propranolol.

Seventeen hypertensive out-patients, more or less unresponsive to previous treatment with antihypertensive drugs, were treated in a cross-over fashion with placebo, prazosin (Pz), methyldopa (MD), Pz + MD, Pz + clonidine (C) and Pz + propranolol. The antihypertensive responses to Pz 2 mg t.i.d. and MD 250 mg t.i.d. were poor, and only modest when the drugs were combined. The combination of Pz with low doses of C was about as effective as Pz + MD, and some patients failed to respond to it. Nor was the combination of Pz + propranolol effective in those cases but the addition of a diuretic produced good responses in all patients. Side effects were few. It is concluded that a combination of central and peripheral sympathetic blockade does not necessarily produce normotension, and that a diuretic added to this combination greatly improves the response.

Adult↗
PubMed1978

The effect of transfer factor on cystic acne.

A chromatographically purified component of human dialysable transfer factor, previously described as causing a non-specific stimulation of cell-mediated immunity, was used as a therapeutic agent in three cases of stage IV cystic acne. The treatment caused a marked strengthening of skin test responses and had a promising effect on skin eruption in each case.

Acne Vulgaris↗
PubMed1977

Comparison of a new antihistamine HC 20-511 with cyproheptadine (Periactin) in chronic urticaria.

The effect and tolerance of a new antihistamine, HC 20-511, in daily doses of 2 and 4 mg was compared with cyproheptadine (Periactin) 8 mg daily in 50 cases of chronic urticaria. HC 20-511 4 mg daily proved to be the most effective, rapid and long-lasting. HC 20-511 had less sedative effect than cyproheptadine, but both possessed the same appetite-stimulating effect. However, this was not noted with the smaller dosage of HC 20-511.

Adult↗
PubMed1976

Erythema nodosum and erythema multiforme associated with milker's nodules.

An epidemic of 44 cases of milker's nodules was recorded in the Tampere Central Hospital catchment area in Finland during the autumn of 1974. Exanthema or erythema multiforme-like secondary eruptions were seen in 10 cases. One female patient is reported in detail because of the simultaneous occurrence of erythema nodosum and erythema multiforme. The virological diagnosis was confirmed by electron microscopy.

Adult↗
PubMed1975

A new antihistamine hc20-511 compared with dimetinden (fenistil retard) in the treatment of chronic urticaria and other pruritic dermatoses.

The new antihistamine, HC20-511 (Sandoz), was compared with Dimetinden (Fenistil retard) in a single-blind comparative study in 42 patients with dermatoses, 28 of whom suffered from chronic urticaria. HC20-511 had a better effect, especially in chronic urticaria, where pruritus, erythema and papules quickly disappeared. The effect appeared somewhat faster than and lasted as long as that of Dimetinden, although HC20-511 is not a retard-preparation unlike the Dimetinden preparation used for comparison. HC20-511 also caused less side effects.

Adolescent↗