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Biomedical subjects

K Kunze

Publications and source records attributed to K Kunze.

At least 73 records · Page 4Linked to original sources
PubMed1989

The Hamburg Stroke Data Bank: goals, design and preliminary results.

A stroke data bank has been developed which consists of 1500 items, including clinical and laboratory findings, past medical history, treatment and outcome. In addition to previously published registries, the Hamburg Stroke Data Bank allows storage of time-dependent data: multiple findings can be entered at different times after stroke onset. The data bank runs on any MS-DOS microcomputer and can be operated without computer knowledge. The stroke registry is conceived to support a prospective, local, multicentre study of stroke. This paper describes objectives, data bank structure and preliminary results of the pilot phase, which includes data of 441 patients with completed stroke and reversible ischaemic deficits. Demographic characteristics, incidence of stroke types, associated risk factors and outcome are evaluated.

Adolescent↗
PubMed1989

NERVTRACK--a neuroanatomical data bank.

To provide the neurologist with a detailed and easily accessible neuroanatomical reference, we have developed a data bank including all relevant efferent and many afferent neuroanatomical pathways. NERVTRACK contains 4000 anatomical data items arranged in a tree-like manner reflecting structural and functional relationships. The program is able to address problems like the following: (1) What is the spinal, radicular, and peripheral innervation of a given muscle? (2) Which muscles are affected by a lesion of a given peripheral nerve, a root, or a segment of the spinal cord? (3) For a given muscle, what are synergists and antagonists, and which clinical test is applicable to evaluate its strength? NERVTRACK runs on IBM-compatible microcomputers, even on lap tops. It is a fast and comfortable reference for clinical practice and serves as a readily accessible teaching aid.

Expert Systems↗
PubMed1989

The MICROSTROKE expert system for stroke type diagnosis.

MICROSTROKE is a prototype expert system designed to categorize and diagnose stroke types based on clinical information. The knowledge base of MICROSTROKE includes information from large stroke registries. The system first queries the physician-user for details of the patient's history, information about the onset of stroke, accompanying symptoms, and pertinent neurologic findings and then sums the individual data items, factors in the a priori odds, and arrives at the probabilities of different stroke types for a given patient. Specific diagnosis of stroke type includes thrombosis, embolus, lacune, intracerebral hemorrhage, and subarachnoid hemorrhage. Stroke type diagnoses by MICROSTROKE were correct in 72.8% of 250 cases in the Hamburg Stroke Data Bank. MICROSTROKE runs on any MS-DOS microcomputer and is intended as a practical aid for physicians not fully familiar with the diagnosis of stroke types.

Cerebrovascular Disorders↗
PubMed1989

The TOPOSCOUT expert system for stroke localization.

Clinically, strokes are localized by the findings on neurologic examination. TOPOSCOUT is an expert system designed to diagnose the anatomic location and the corresponding vascular territory of strokes based on the clinical signs and symptoms. The inference engine of TOPOSCOUT uses a backtracking algorithm and a rule-based data base that includes associations of neurologic signs with vascular and anatomic areas. TOPOSCOUT is capable of detecting typical stroke patterns, for example, "top-of-the-basilar" or Wallenberg's syndromes. The accuracy of TOPOSCOUT's diagnoses has been tested for conformity with the final diagnoses of 129 patients in the Hamburg Stroke Data Bank, and a high level of agreement was found for hemispheric lesions. The program runs on microcomputers with MS-DOS and is intended as a practical aid for physicians not fully familiar with topologic stroke diagnosis and as an interactive teaching device.

Cerebral Arteries↗
PubMed1989

[Follow-up studies and results of dorsal stabilization of unstable spinal fractures].

Temporary dorsal plate spondylodesis with transpedunclar screwing has proved successful in the therapy of recent unstable injuries to the spine. This method allows a considerable reconstruction and stabilization of the vertebral body as well as an early mobilization of the patient. The mobility of the spine will not be essentially reduced if the spondylodesis plates are removed early, i.e. six to nine months after their insertion.

Adult↗
PubMed1988

Spontaneous subarachnoid haemorrhage: expert system for appraisal of the prognosis and computer-supported decision for therapy.

An expert system is presented which allows appraisal of the prognosis and a computer-supported decision for the therapy of patients with acute spontaneous subarachnoid haemorrhage (SAH). The knowledge of physicians as a synthesis of their own and other clinicians' experience is simulated with methods of artificial intelligence by setting up two data banks. In one data bank, selected information on the correlation between initial clinical parameters, on the one hand, and mortality, outcome and complications, on the other, from about 250 neurological publications is stored, taking into consideration the therapeutic regimens applied. A second data bank receives clinical and laboratory data profiles of a patient population which has already been treated. The expert system is able to compare the individual initial findings with the corresponding parameter combination stored in the data banks regarding the decision for therapy of a patient to be treated. This enables both calculation of the probable complications and prediction of the expected outcome in relation to various possible forms of therapy. The expert system can thus indicate the kind of therapy where the lowest number of complications and the best outcome can be expected, thus supporting the decision of the physician. As each new patient is treated, the volume of stored information increases, so the system possesses self-learning characteristics. To check the validity of the prognoses, the outcome estimated by the expert system for 51 patients with spontaneous SAH was compared with the actual outcome, and a high level of agreement was attained.

Decision Making, Computer-Assisted↗
PubMed1988

[Prognostic significance of initial clinical and instrumental parameters in spontaneous intracerebral hemorrhages].

We retrospectively analyzed the records of 63 consecutive patients with spontaneous intracerebral hemorrhage (ICH) who had been treated in our neurological intensive care unit from 1981 to 1985 (aged 17 to 84 years). In this sample, the prognostic value of initial clinical and laboratory findings was studied. The following factors were significantly correlated with mortality: concomitant cardiac failure, general atherosclerosis, and chronic obstructive pulmonary disease; coma or deranged brainstem reflexes on admission; concomitant intraventricular or subarachnoid hemorrhage, hydrocephalus and midline shift on CT scan. ICH location did not significantly correlate with outcome. Among lobar ICH occipital hematomas carried the best prognosis. No prognostic importance was detected for age and gender, initial blood pressure, time interval between ICH and admission, ECG or angiographic findings, or laboratory values.

Aged↗
PubMed1988

Ultralate cerebral potentials as correlates of delayed pain perception: observation in a case of neurosyphilis.

Evoked cerebral potentials were investigated in a patient with neurosyphilis, who showed the symptoms of delayed pain perception in the lower limbs: a pinprick to the legs was perceived with a latency of more than one second. After stimulation with CO2 laser radiant heat pulses, evoked cerebral potentials of upper limbs were observed in a latency range comparable to those of healthy subjects, with a negative peak at 250 ms and a positive peak at 370 ms. In contrast, after application of laser stimuli to body sites with delayed pain perception, latency of the evoked potentials drastically increased with a vertex negativity at 1300 ms and a positivity at 1420 ms. Evoked potential measurements with conventional electrical stimuli did not show any difference between affected and unaffected body sites, that is, stimulation of the affected body sites did not produce pathological potentials.

Afferent Pathways↗