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Biomedical subjects

K Kume

Publications and source records attributed to K Kume.

215 records · Page 12Linked to original sources
PubMed1977

Experimentally induced synovitis of chickens with Mycoplasma synoviae: effects of bursectomy and thymectomy on course of the infection for the first four weeks.

Specific pathogen-free chickens (bursectomized and x-irradiated (SBx-X), thymectomized and x-irradiated, x-irradiated, as well as nontreated) were inoculated (in the right tibiometatarsal joint) at the 4th week after hatching with a synovitis-derived Mycoplasma synoviae strain. Differences were not observed in recovery rate of mycoplasmas from tissues among these groups. The SBx-X chickens which were killed at 2 and 4 weeks after the intraarticular inoculation or which died during this period and bacteremia and severe synovitis with edema and heterophil infiltration in synovial fluid and in area from synovial membrane to subcutaneous tissue. Swelling of left leg joints or foot pads were observed mainly in the SBx-X group. A significant difference in the mortality rate and severity of airsacculitis was observed between SBx-X and other groups. The thymectomized and x-irradiated chickens did not show edema, synovial fluid, or swelling in the joint area. However, small lymph follicles composed of lymphoid and plasma cell were formed locally in synovial membranes of various joints. These results indicated that bursa-dependent lymphocytes are correlated with resistance to develop the lesions and that thymus-dependent lymphocytes are necessary for macroscopic lesions to develop.

Animals↗
PubMed1975

A field trial, using killed-Mycoplasma gallisepticum vaccine to protect against chicken respiratory mycoplasmosis.

In a field trial with chickens, the efficacy of killed Mycoplasma gallisepticum vaccine against respiratory mycoplasmosis was determined. Broiler chickens were vaccinated by aerosol administration at 3, 14, and 25 days of age, and observations were made of survival rate, body weight gain ratio, macroscopic lesion grade of airsacculitis, isolation of organisms, serologic test results, histopathologic changes, and clinical signs. Inhalation of the vaccinal aerosol did not influence livability and body weight gain ratios. In the control group, M gallisepticum, M synoviae, or both, wereisolated in 6 of 10 chickens at age 84 days and in 1 of 10 chickens at age 134 days. In all of the vaccinated groups (10 broilers each), however, results of bacteriologic cultural examination during the observation period were negative. The killed M gallisepticum vaccine also suppressed increase of antibody titers in the tube agglutination and the hemagglutination-inhibition tests at different intervals. Both the histopathologic changes and the clinical signs appeared minimal in the vaccinated group.

Aerosols↗
PubMedDate not supplied

A clinicopathological study of gastric cancer with special reference to age of the patients: an analysis of 1,630 cases.

A series of 1,630 patients with gastric cancer was reviewed with special reference to their ages. The overall resectability rate was 84.6%. With increasing age, there was also an increase in: the male-to-female ratio, the frequency of tumors located in the distal third of the stomach, and the degree of differentiation of the carcinoma (p less than 0.01). There was no age-related association to: tumor size, early gastric cancer of 30-40%, macroscopic classification, histological staging, or symptomatology. The 5-year survival rates did not differ significantly among the various age groups. From 1980 to 1984, clinical characteristics were evaluated in 58 patients under 40 years of age and in 39 patients 80 years of age and older. Preexisting medical illnesses and postoperative complications were more frequent in the aged group; however, there were no operative deaths in either group. In conclusion, although there are several distinct properties depending on the age of the patients, very elderly as well as young patients can be successfully treated.

Adolescent↗
PubMedDate not supplied

Pre-operative imaging can diagnose torsion of the gallbladder: report of a case.

Torsion of the gallbladder is a rare disease and pre-operative diagnosis of the disease is uncommon. About 400 cases have been reported, but only 4 were diagnosed by pre-operative imaging. We report on a case of gallbladder volvulus diagnosed pre-operatively using pre-operative imaging with ultrasound and computed tomography.

Aged↗
PubMedDate not supplied

Portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt: three cases and literature review.

Extrahepatic portal-systemic encephalopathy due to congenital extrahepatic portosystemic shunt has so far been rarely reported in the literature. We herein report 3 such cases without liver cirrhosis or portal hypertension which were presented with the chief complaint being disturbance of consciousness and abnormal behavior. In all cases the brain computed tomography scan revealed no pathological findings, while electroencephalogram showed a diffuse slow activity with triphasic waves. The laboratory data revealed a high serum ammonia level. Percutaneous transhepatic portography demonstrated portosystemic shunts. After these shunts were surgically occluded, the serum ammonia level reached a normal range and encephalopathy disappeared. A liver biopsy also revealed neither fibrosis nor cirrhosis in any of the cases. The 23 previously reported cases are also discussed.

Aged↗
PubMedDate not supplied

Clinicopathological features of long-term survivors of scirrhous gastric cancer.

BACKGROUND/AIMS: Prognosis of scirrhous gastric cancer remains low. To determine the clinicopathological features that are correlated with prognosis, we studied long-term survivors of scirrhous gastric cancer (survival duration more than 5 years) in comparison with patients with short survival. METHODOLOGY: Among 2719 gastric cancer patients who underwent surgery at Matsuyama Red Cross Hospital, 211 cases were diagnosed as scirrhous type gastric cancer. Seventeen patients survived more than 5 years, and the rest had short survival (less than 5 years). Comparison of clinicopathological factors was done by chi 2 analysis. Multivariate analysis was done in order to focus on the prognostic factors. RESULTS: The 5-year survival of the total 211 patients was 12%. The 5-year survival of patients who underwent curative surgery (67 cases) was 30%, which was significantly higher than that of the non-curative surgery group (144 cases, 6%). Significant differences were noted in the following variables: peritoneal dissemination, hepatic metastasis, lymph node dissection, pattern of infiltrating growth, depth of invasion, histological lymph node metastasis, histological stage, and histological curability. Patients with either hepatic metastasis or peritoneal dissemination did not survive 5 years. Multivariate analysis revealed that the most significant independent prognostic factor was histological curability, followed by peritoneal dissemination. CONCLUSIONS: There is a possibility of long-term survival for patients with scirrhous gastric cancers without hepatic metastasis, peritoneal dissemination, or extensive lymph node metastasis. Curative surgery is important, suggesting that the extended operation is rational if possible.

Adenocarcinoma, Scirrhous↗
PubMedDate not supplied

The nutritional advantages of proximal gastrectomy for early gastric cancer.

BACKGROUND/AIMS: Total gastrectomy has generally been performed for the treatment of early gastric cancers involving the upper third of the stomach. However, proximal gastrectomy has also been used for the treatment of cardial early gastric cancer. METHODOLOGY: To compare the nutritional parameters after proximal gastrectomy with the parameters after total gastrectomy, and to also determine the advantages of the postoperative nutritional states, a retrospective analysis was made to evaluate the nutritional status of patients with early gastric cancer who underwent proximal gastrectomy with those undergoing total gastrectomy. Forty-nine patients were studied for one year after surgery; 9 underwent proximal gastrectomy while 40 had a total gastrectomy. RESULTS: Proximal gastrectomy allowed the patient to better maintain both their nutritional parameters and body weight. CONCLUSIONS: Proximal gastrectomy was thus found to be a beneficial modality for early gastric cancer patients regarding terms of the postoperative nutritional status, in comparison to total gastrectomy.

Aged↗