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Biomedical subjects

K Krug

Publications and source records attributed to K Krug.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Observations on polymyalgia rheumatica].

The polyalgia rheumatica, which appears in one part of the patients together with a giant cell arteritis of the region of shoulder girdle and pelvic girdle. Also intensive temporal artery, is manifest with severe pains of their headache may be dominant in the disease. Observations on 14 own patients who belong to this picture of the disease confirm the initially existing and under glucocorticoids rapidly reversible severe general humoral reactions. Up to now the incompletely tested immunological phenomena are not specific for the polyalgia rheumatica and must be supplemented by further examinations.

Aged↗
PubMed1980

[Pathophysiology of aplastic anemia and its treatment with methenolone enanthate].

For the development of an aplastic anaemia a large number of causes is taken into consideration. In our own clinical material of 26 patients in 15 patients none of the up to now known noxae could be established. Recently in the clarification of the picture of the disease important pathophysiological realizations were got. In these cases disturbances of the stem cell compartments, effects through the matrix of the haematopoietic cells and immunological processes have been recognized as significant. --Own investigations concerning the therapy with the anabolic metenolonenanthat (Primobolan-S) yielded approximately the same large number of therapeutic failures and patients with a good result of the treatment or a partial remission in 15 idiopathic and 11 toxically conditioned anaemias. In the partial remissions in most cases a thrombocytopenia continued existing. A therapy lasting at least two months is necessary in order to estimate the result of the therapy. At the present time cannot yet be predicted on which conditions the use of anabolics will be successful.

Anemia, Aplastic↗
PubMed1979

[Serology of toxoplasmosis in patients with lymphogranulomatosis].

The technical progress in the development of the fiber coloscopy gives the possibility to inspect the whole large intestine including the terminal ileum. The essential contribution of the coloscopy consists in the early diagnosis of the carcinoma of the large intestine. The malignant change of the polyp may be proved or excluded only after total polypectomy. In our clinical material consisting of 250 patients in 44% of the cases the total coloscopy confirmed the radiological suspicion. In 38% of the cases the pathological changes of the large intestine could be excluded, and a laparotomy was unnecessary. In 18% another severe finding of the large intestine was established. In haemorrhage of the large intestine of unclear genesis the coloscopy made possible the final recognition of the source of haemorrhage in 92% of the cases. In patients with colitis we established coloscopically larger changes than could be assumed on the basis of the barium enema. The total coloscopy given a highest possible certainty in the diagnostics of the large intestine.

Adolescent↗
PubMed1979

[Liver involvement in lymphogranulomatosis].

Of 146 patients with lymphogranulomatosis biochemical parameters were tested for their diagnostic valency concerning the recognition of a liver infiltration. In patients with histologically proved affection of the liver the AP, GGTP, AAP, LAP and LDH show a significant increase in comparison to the enzyme values of the patients without any hepatic manifestation. In an increased result of 4 enzyme values with a probability of 85% muste be reckoned with a participation of the liver. The enzyme SGOT, SGPT, GDH, LDH-isoenzymes, choline esterase, beta-GC, the De Ritis quotient and the quotient (Formula: see text), on the other hand, do not give any additional differential-diagnostic information.

Acid Phosphatase↗
PubMed1979

[Bone changes in hemoblastoses and malignant lymphomas].

In haematological systemic diseases such as acute and chronic leukoses, malignant lymphomas, lymphogranulomatoses, osteomyelofibroses, polycythaemias and aplastic anaemias with a different proportion changes of the bones in form of osteoporoses, osteolytic processes and deformations of the vertebral bodies are to be found. The proof may be performed radiologically and histologically. In 461 patients with different haematological diseases absorption measurings of monoenergetic rays of a J-125-source were performed at the distal third of radius and ulna. It was shown that the bone mineral content of patients with proved bone destructions did not significantly differ from the normal group. The too peripherally located place of the measuring and also the late inclusion of the compacta into the changes is regarded as cause for the negative result.

Bone Diseases↗
PubMed1979

[Diagnosis and therapy of idiopathic thrombocytopenic purpura].

To the diagnostics of the idiopathic thrombopenia caused by autoantibodies belong: 1. the clinical findings such as type of haemorrhage and the controls of the capillary function. 2. the proof of antibodies, in which case positive findings are proving, but negative ones do not exclude the immune thrombopenia, 3. smear of the sternal marrow with judgment of the megakaryocytes and formation of thrombocytes, 4. isotopic control of the survival time of the thrombocytes, which is reserved to special insitutions. As therapy essentially three forms have developed: 1. Therapy with glucocorticoids, 2. Immunosuppressive drugs, 3. Splenectomy. In own observations of 48 patients the glucocorticoids bring an actual improvement only for 7 patients, the others fail in therapy or show only a partial remission. The least prospects are in the immunosuppressive drugs, being equal whether preceding or accompanying a glucocorticoid therapy was performed. Most successes (11 out of 16 patients) are to be stated in splenectomy. Following an after-control of all therapeutic methods together a successful therapy results only in one third, in the next two thirds the therapy either fails or at most evokes a partial remission.

Coombs Test↗
PubMed1978

[Varying course of pancytopenia after busulfan treatment of chronic myelocytic leukemia (CML)].

In 84 patients with chronic myeloid leukaemia receiving a cytostatic monotherapy with busulfan, an aplastic syndrome developed which was confirmed by a biopsy of the pelvis crest and examination of the sternal marrow. The time interval until pancytopenia was detected varied considerably in each case, ranging between 6 and 126 months. There are no correlations to the initial doses of busulfan. 3 patients died of the immediate effects of the bone-marrow damage caused by busulfan. In 4 from 6 of the following pancytopenic patients the leukocyte values lay between 12,800/microliter and 80,400 microliter when busulfan adminstration was interrupted. Thus, it is scarcely possible to give any reliable informations about a leukocyte limit value as a standard for an interruption of therapy in order to prevent bone-marrow aplasia. Taking this into account, the conclusion may be drawn that relatively short control intervals have to be made in this monochemotherapy of CML which often can be used successfully for many years.

Adolescent↗
PubMed1977

[Diagnostic and differential diagnostic value of cytological findings in toxoplasmic lymphadenitis].

The cytologic investigation of needle biopsy material from lymphomas of unclear genesis may give valuable diagnostic references in patients with lymphadenitis toxoplasmotica. Findings of 19 patients are explained. Suspicious for a toxoplasmogenic genesis are colouredness of the cell picture with large basophilic roundnuclear cells, conspicious macrophagocytosis in reticulum cells and small-focal proliferation of the epitheloid cell. In own material these 3 criteria only 5 times appeared together. Two simultaneously existing, suspicious for Piringer's lymphadenitis findings, were shown in 11 patients. Most frequently was found the coloured picture of the round-nuclear cells (16/19). A conspicuous RHS-phagocytosis was to be observed in 12 smears. In careful clinical and serological controls only in 4 out of 19 patients a histological investigation was necessary. In the cytological findings also other lymphomatous processes must differential-diagnostically be taken into consideration.

Adolescent↗