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Biomedical subjects

K Krishnaswamy

Publications and source records attributed to K Krishnaswamy.

At least 91 records · Page 5Linked to original sources
PubMed1976

Undernutrition and tetracycline half life.

The plasma half life of tetracycline hydrochloride was determined in groups of well-nourished and undernourished subjects employing two dosage schedules and two routes of administration, namely oral and parenteral. Protein binding of the drug was estimated and relative volume distribution was calculated. The results indicated that in undernourished subjects, the half life of tetracycline hydrochloride, protein binding and relative volume distribution were all significantly low as compared to well-nourished subjects. The elimination rate was considerably higher in the undernourished groups, which accounted for the shorter half life. These data suggest that to maintain adequate serum concentrations of the drug in undernourished subjects, tetracycline needs to be given at more frequent intervals.

Administration, Oral↗
PubMed1976

Effect of vitamin B6 on leucine-induced changes in human subjects.

Distrubances in the tryptophan-niacin pathway seen in endemic pellagra among sorghum eaters have been ascribed to high dietary intake of leucine. Vitamin B6 plays an important role in several steps of this pathway. Therefore, studies on possible metabolic interrelations between excess dietary leucine and vitamin B6 were undertaken in normal healthy human subjects. The results indicated that vitamin B6 could successfully counteract the effects of leucine on quinolinic acid excretion in urine, and on in vitro nicotinamide nucleotide synthesis by erythrocytes, and also could correct the abnormalities of 5-hydroxytryptamine metabolism induced by excess leucine. These observations suggest that vitamin B6 nutritional status may have a contributory role in the pathogenesis of endemic pellagra.

Adult↗
PubMed1975

Serotonin metabolism is pellagra.

Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.

Adult↗
PubMed1975

Role of vitamin B6 on leucine-induced metabolic changes.

Administration of leucine at 3% level in the diet has been shown to increase tryptophan oxygenase activity and to decrease kynureninase activity in the liver and to increase quinolinic acid excretion in the urine of rats fed low amounts of vitamin B6 (0.5 mug/g diet). Vitamin B6 at 3 mug/g of diet was able to reverse the effects of leucine on enzyme activities, but not on quinolinic acid excretion. Isoleucine at 0.2% level could counteract the leucine effect on kynureninase but not on tryptophan oxygenase. Administration of leucine also decreased the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the brain. Simultaneous administration of isoleucine could counteract the effects of leucine on brain 5-HT and 5-HIAA partially at low amount of vitamin B6 but completely at higher levels of vitamin B6 in the diet.

Animals↗
PubMed1975

Tropical ataxic myelopathy.

A syndrome of ataxic myelopathy with optic atrophy and perceptive deafness has been described. This is essentially similar to the Nigerian ataxic myelopathy which has been ascribed to chronic cyanide intoxication through dietary means. The results of biochemical investigations and bone marrow examination indicate that neither vitamin B12 deficiency nor cyanide intoxication are likely factors in the detiology of our cases. It is possible that the disease may be due to an unrecognized toxic for factor which may or may not be of dietary origin.

Adult↗
PubMed1975

Famine oedema.

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Adult↗