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Biomedical subjects

K Krishan

Publications and source records attributed to K Krishan.

29 records · Page 2Linked to original sources
PubMed1985

Skeletal muscle metabolism in mice bearing adenocarcinoma. II. Histochemical alterations in acid and alkaline phosphatases.

In Swiss albino mice bearing adenocarcinoma the degree of pathological damage as revealed by the activities of acid and alkaline phosphatases is greater in skeletal muscles closely proximal to the tumor site than in those away from it. Acid and alkaline phosphatases in myofibres of triceps, pectoralis and gastrocnemius muscles show a direct relationship between myofibre necrosis and activities of these phosphatases.

Acid Phosphatase↗
PubMed1985

Skeletal muscle metabolism in mice bearing adenocarcinoma. I. Histochemical alterations in glycogenolytic, glycolytic, lipolytic and oxidative metabolism.

Metabolism of triceps, pectoralis (in the vicinity of tumor) and gastrocnemius (away from the tumor) muscles in Swiss albino mice bearing adenocarcinoma has been studied histochemically with regard to content of glycogen, lipids, phosphorylase, aldolase, lipase, succinate dehydrogenase and cytochrome oxidase in the constituent fibres. At 9-10 weeks after transplantation of adenocarcinoma, a negligible glycogen content and decreased phosphorylase and aldolase activities are observed in the white, intermediate and red fibre types in the three muscles. Hypertrophy of fibres and occurrence of targetoid fibres is distinct in the muscles of tumor-bearing mice. The red fibres demonstrate a general loss of lipids, lipase, succinate dehydrogenase and cytochrome oxidase whereas the hypertrophied fibres reveal intense localization of these parameters in their central zones. The results indicate that a decline in glycogenolysis, glycolysis, lipolysis and oxidative metabolism in the various fibre types may contribute to the muscle weakness and muscle wasting in the adenocarcinoma-bearing mice.

Adenocarcinoma↗
PubMed1980

On the determination of skeletal muscle types in Swiss albino mouse.

Biochemical characteristics of the red, white and intermediate types of muscles have been studied with regard to the alterations in their glycogen, acid and basic proteins, nucleic acids (DNA and RNA) and SDH-activity, during the period of post-natal growth. The results of the investigation, which has been conducted on M, soleus, M. tibialis anterior and M. sartorius of Swiss albino mouse, indicate the predetermination of the biochemical characteristics of each muscle type with respect to the parameters studied and do not show post-embryonic differentiation.

Animals↗
PubMedDate not supplied

Circadian desynchronization in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in traumatic tetraplegics.

An investigation was undertaken to study the circadian rhythmicity in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in eight traumatic tetraplegics in view of the fact that diurnal rhythmicity in prolactin response to thyrotropin-releasing hormone was absent in such patients. The data, analysed by single cosinor procedure, showed absence of rhythmicity in all five parameters. Analysis of variance also showed no significant difference in these parameters at various time points. Knowledge of the alterations in circadian biology subsequent to cervical spinal cord trauma would provide useful guidelines towards chronotherapy and vocational rehabilitation of tetraplegics besides possible restoration of euchronism by pharmacological means.

Adolescent↗