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K Kozlowska

Publications and source records attributed to K Kozlowska.

40 records · Page 3Linked to original sources
PubMedDate not supplied

[Renal function in children after treatment of acute lymphoblastic leukaemia (ALL)].

UNLABELLED: The aim of the study was to evaluate the renal function (on the basis of serum: cystatin C, creatinine, beta2-microglobulin(B2M) levels, creatinine and cystatin C clearance, and urine osmolality) in 37 children with ALL (acute lymphoblastic leukaemia) after completing intensive treatment (9 in course of maintenance therapy), depending on nephrotoxic antibiotics use (</=3 times vs > 3 times) and methotrexate dose (1.0 g/m2 vs 5g/m2). The control group was formed by 15 healthy children. RESULTS: 1) Serum cystatin C, creatinine, beta2-microglobulin levels creatinine and cystatin C clearance, and urine osmolality were similar in the analysed and control groups. 2) We did not find any differences between the analyzed parameters in the groups of children: a) in maintenance therapy and after the end of the therapy, b) received methotrexate in the dose of 5.0 g/m2 vs 1.0 g/m2, c) not treated children and treated </= 3 times and gt; 3 times with nephrotoxic antibiotics. CONCLUSION: The renal function is normal after completion of antileukaemic therapy in spite of previous use of nephrotoxic drugs.

Adolescent↗
PubMedDate not supplied

Implication of macrophage no and cytokine secretion in the cytotoxicity of transplantable melanomas as regards the progression of these tumors.

We studied the connection between the secretion of TNF-alpha, IL-6, OSM and NO by hamster peritoneal macrophages (animals bearing two forms of hamster transplantable melanomas of common origin but differing in growth rates, levels of differentiation and immunogenicity) and the cytotoxic effect of these macrophages on the cells of those two melanoma lines. The melanotic melanoma, the native form of melanoma, evoked an increase of cytokine secretion, especially of TNF-alpha, while the amelanotic melanoma line caused an increase of macrophage cytotoxic activity and of NO release. These observations seem to reveal that the biological features of transplantable melanomas and their progression influenced changes in the cytotoxic activity of peritoneal macrophages by changing the effector mechanism of this phenomenon.

Journal Article↗