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Biomedical subjects

K Kosuga

Publications and source records attributed to K Kosuga.

At least 181 records · Page 10Linked to original sources
PubMed1985

The surface lining cells of cardiac myxoma. Light, electron microscopic and immunohistochemical observation.

Morphological, enzymatic and electron microscopic studies have been performed on the surface covering cells of cardiac myxoma (CM) in 4 clinical cases. The superficial layer of CM is composed of mono- or poly-layers of polygonal cells and the superficial cells are connected with the tumor cells within CM. Electron microscopic picture showed many microvilli on the surface of the superficial cells, and the neighboring cells extend extrusions one to another connecting with desmosomes. Formation of incomplete basal membrane was observed in the underlying cells. These cells were morphologically similar to those of the tumor cells in CM. Polygonal superficial cells were shown by scanning electron microscope, and there was no consistent arrangement, which was different from the vascular endothelial cells. Factor VIII-related antigen was proved in the tumor cells having vascular like space in CM, suggesting differentiation of the tumor cells to the vascular endothelial cells. Factor VIII-related antigen was negative in the superficial covering cells. It may be said that the superficial covering cells of CM are premature tumor cells having no character as endothelial cells.

Adult↗
PubMed1985

Calcification of matrix vesicles in cardiac myxoma.

The mechanism of calcification in cardiac myxoma, using histologic, ultrastructural and potassium pyroantimonate technique was demonstrated. There are a large number of extracellular membrane-invested structure measuring 100-700 millimicrons in cardiac myxoma. These structures are similar to the matrix vesicles observed in skeletal tissue and atherosclerotic foci. Potassium pyroantimonate reacts with these vesicular structures and degenerated myxoma cells. It was thought that calcification in cardiac myxoma occurs by the same mechanism as calcification in atherosclerosis.

Aged↗
PubMed1985

[Surgical therapy of the patient with valvular lesion combined with coronary disease].

We studied on operative indication, operative problem, and operative result in patients with valvular lesion with coronary disease. In 650 cases, 51 cases combined with coronary stenosis and ACBG (9 cases) or OTCA (6 cases) were performed in 15 cases of them. For operative indication, ACBG was applied in case with proximal stenosis of more than 70% and OTCA was applied in case with mild localized stenosis. Cardioplegia during operation was important and heart temperature should be kept less than 15 degrees C. In those cases with combined operation, there were no early deaths but one late death (3 years after operation). After operation, chest pain disappeared and clinical symptom and ability for exercise were improved. According to NYHA classification, the improvement before and after operation were class I, none and 11 cases; class II, one case and three cases; class III, 12 cases and none and class IV, two cases and none.

Adult↗
PubMed1984

[Valvuloplasty for congenital mitral valvular diseases].

Valvuloplasty is first applied as the surgical treatment for congenital mitral regurgitation (MR). Follow up study after the operation around the valvuloplasty was performed in the patients with congenital MR. In the patient under 12 years old, there were isolated MR in 3; MR associated with VSD in 14; MR and ASD in 3; MR with PDA in 10; and MR with ECD in 36. Operative methods were suturing of mitral cleft in 27; mitral annuloplasty in 17; mitral valve a, advancement in 7; cusp plasty in 4; no treatment for the MR in 14. Early death was noted in 6 cases (9.0% of mortality) and late death was noted in 3 cases (mortality rate of 9.0%). Conclusions were as follows: Surgical treatment was required in the patients with MR more severe than Sellers' Grade-II. Single suturing was recommended for the suturing of mitral cleft because shortening of the valve occurred in a few degree and the residual regurgitation reduced. Mitral valve advancement by elongation of the valvular apex was useful for the impediment of the regurgitation caused by incompetence of mitral coaptation. Mitral annuloplasty increased the effect for the impediment of the regurgitation. Ultrasonic cardiogram was useful for the follow up after the operation of the mitral valvuloplasty.

Child↗
PubMed1984

[Surgical treatment of infective endocarditis in childhood--report of 3 cases].

This is the case report of 3 surgical patients with infective endocarditis in childhood. Case 1: A 8 year-old boy was admitted with high fever and congestive heart failure. Aureus staphylococci were identified by blood culture. Echocardiogram showed a vegetating mass on the posterior mitral leaflet. This patient was cured by emergency mitral valve replacement during the active phase of infection. Case 2: A 3 year-old girl was admitted with infective endocarditis related to VSD. Viridans streptococci were identified by blood culture. Echocardiogram showed a vegetating mass on the septal tricuspid leaflet. After successful antibiotic therapy, this patient underwent the closure of VSD and tricuspid valvuloplasty. Case 3: A 7 year-old boy was admitted with infective endocarditis related to VSD. Aureus staphylococci were identified with blood culture. Echocardiogram showed a vegetating mass on the anterior tricuspid leaflet and moderate tricuspid regurgitation. After successful antibiotic therapy, this patient underwent the closure of VSD and tricuspid valvuloplasty. We believe that echocardiography plays an important role in the diagnosis and management of infective endocarditis and that tricuspid valvuloplasty is the method of first choice in treatment of the patient with regional tricuspid infective endocarditis.

Child↗
PubMed1983

[Cardiac myxoma--light, electron microscopic and immunocytochemical assessment of histogenesis].

Fourteen cardiac myxomas exhibiting a variety of histologic patterns were examined by light microscopy and the peroxidase anti peroxidase technic using factor VIII relating antigen. Four were also studied by election microscopy. Tumor cells showed variable cellular arrangements, e.g. cord clusters of rounded cells, network-like arrangement, concentric myxoma cell layers and vascular-like structures. Electron microscopically, these myxoma cells revealed smooth muscle-like cells, fibroblast-like cells and endothelial cells. Factor VIII-related antigen was found in some of the single tumor cells, in endothelial-like cells of the vascular-like structures and in cells on the inner side of the concentric cell layers. Cardiac myxoma arises from multipotential mesenchymal cells in the endocardium of the atrial septum which may develop into smooth muscle cells, fibroblasts, cartilage cells and endotherial cells.

Adult↗