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Biomedical subjects

K Kostial

Publications and source records attributed to K Kostial.

At least 91 records · Page 5Linked to original sources
PubMed1975

Tetracyclines and lead metabolism in rats.

The effects of oral, parenteral pretreatment, and posttreatment with tetracyclines on lead metabolism were studied in 7 to 9 week-old female rats. In animals receiving different doses of tetracyclines orally (30 to 600 mg/kg daily) for 12 days the retention of an oral dose of 203Pb applied on the 4th day of the treatment was, at the end of the experiment, the same as in the controls. In animals receiving daily intraperitoneal doses of tetracycline (18.8 to 75 mg/kg for 12 days) the retention of an intraperitoneal dose of 203Pb applied on the 4th day of treatment was, at the end of the experiment, the same or higher than in the untreated group. This indicates that tetracyclines are not likely to be useful in the prevention or treatment of lead poisoning.

Animals↗
PubMed1974

Manganese ions and synaptic transmission in the superior cervical ganglion of the cat.

1 In the perfused superior cervical ganglion of the cat manganese ions (2.7 - 4.6 mM) caused a block of synaptic transmission and reduced the output of acetylcholine.2 Calcium ions (8.4-10.5 mM) relieved the synaptic block produced by manganese and partially restored the acetylcholine output.3 The presence of manganese also reduced the sensitivity of ganglion cells to injected acetylcholine.4 Both effects of manganese were completely reversible.

Acetylcholine↗
PubMed1971

Reduction in the absorption and retention of strontium in rats.

Rats were fed a stock diet supplemented with calcium phosphate and sodium alginate, both separately and simultaneously, over a period of 4-5 months. Observations were made at intervals on the growth rate and on visual and histological abnormalities in some body tissues. No toxic effects were observed. The absorption and skeletal retention of calcium for rats on the combined supplements remained almost unchanged but the absorption and retention of strontium was reduced 7-fold.

Alginates↗