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Biomedical subjects

K Koski

Publications and source records attributed to K Koski.

At least 55 records · Page 3Linked to original sources
PubMed1993

Trigeminal foraminal patterns in "skeletal" Class II and Class III adults--a radiocephalometric study.

Radiocephalometric analysis, based mainly on the foramina of the trigeminal nerve branches, was applied to three samples of adults, two representing fairly extreme profile types, the third representing "normal" dentofacial build. The aim of the study was to find out whether the analytical method could be used to differentiate between facial types. It appeared that some elements of the method had diagnostic powers, and could substitute for traditional methods. Many dimensions inspected, however, were fairly similar in all facial types, thus suggesting a general basic role of the trigeminal nerve in relation to craniofacial structure. Generally speaking, the foraminal pattern was relatively stable in "normal" faces, but more variable in deviant faces.

Adult↗
PubMed1992

Dietary intake of 70- to 89-year-old men in eastern and western Finland.

A detailed dietary history interview of 70- to 89-year-old men, 98 from eastern and 129 from western Finland, was obtained as part of a 30-year follow-up survey within the Seven Countries Study. The average energy intake was similar in level, about 2700 kcal, in both areas. The percentage of total energy intake from fat was 39.1% in the west, and 36.5% in the east. The P/S ratio was about the same, 0.27 and 0.29, in eastern and western areas, respectively. The intake of most micronutrients was similar in the two cohorts. Only the intake of vitamins A and C and phosphorus, manganese, copper and zinc was higher in eastern Finland than in western Finland. The nutritional density of the diet of the eastern cohort was slightly higher than that of the western one due to their higher consumption of rye products, vegetables and berries, and also sour milk and fish and fish products. The diet met the general recommendations and was comparable to that of younger age groups.

Aged↗
PubMed1991

Trabecular architecture of the mandibular condyle of the rat as revealed by vital staining.

The variability of the internal architecture of bone was studied in the mandibular condyle of young rats with the aid of vital staining capable of revealing bone trabeculae. The effect of season and age was observed in Spring- and Fall-born rats 28 and 56 days of age. There was no clear left-right asymmetry in the average direction of the condylar trabeculae, but their ranges of direction within the condyles exhibited such asymmetry. Both the average directions and the internal variability were different in the medial and the lateral sides of the condyles. There were also small but in most respects significant seasonal differences. These findings indicate that even the relatively small mandibular condyle of the rat is a very complex structure.

Aging↗
PubMed1990

Trigeminal foraminal pattern in the face.

The integration of the trigeminal nerve into the craniofacial skeleton was studied by examining cephalometrically the relationships of the openings of the branches of the trigeminal nerve to each other and to other structures. Lateral cephalograms were taken from 30 adult skulls; several linear and angular dimensions were measured from the cephalograms. The results suggest a relationship between nerve growth and bone growth in the craniofacial skeleton.

Cephalometry↗
PubMed1987

Craniofacial skeleton of 7-year-old children with enlarged adenoids.

In a radiocephalometric study of 7-year-old children, it was found that a diagnostically useful characteristic associated with the presence or past history of enlarged adenoids is a dorsal rotation of the mandibular ramus relative to the palate. This feature may also be common to other obstructions of the nasopharyngeal space. A possible mechanism causing this growth deviation and some methodological problems involved in its detection are discussed.

Adenoidectomy↗
PubMed1981

The passage of flunitrazepam into cerebrospinal fluid in man.

The passage of flunitrazepam into cerebrospinal fluid (CSF) was studied in 23 surgical patients (group 1), after a single 0.02 mg/kg intravenous injection, in 9 otherwise healthy patients undergoing neurological examination (group 2), after a single 2 mg oral dose, and in 9 chronically-ill neurological patients (group 3), after 2 to 4 successive 2 mg oral doses. Flunitrazepam in plasma and the CSF was determined by gas chromatography and its plasma protein binding by equilibrium dialysis. Uptake of flunitrazepam into human CSF was found to very fast: even 5 min. after intravenous injection the drug level in the CSF was 2.8% of the corresponding plasma concentration. CSF levels increased up to 77 min. after intravenous injection. In group 2 the mean percentage level in the CSF was 23.5 +/- 13.0 (S.D.) and in group 3 it was 16.7 +/- 3.1. In group 1, 22.9+/- 8.0% of flunitrazepam was not bound to plasma protein, in group 2, 12.1 +/- 8.3% and, in group 3, 30.3 +/- 14.1%. Groups 1 and 2 (P less than 0.01) and 2 and 3 (P less than 0.01) differ significantly from each other. In groups 2 and 3 there was no significant correlation between the percentage not bound to protein and CSF levels of flunitrazepam. The uptake of flunitrazepam by CSF provides an explanation for its rapid drug effects. Its binding to plasma protein is affected by disease and, possible, by other drugs.

Adult↗
PubMed1981

Pharmacokinetics of dihydroergotamine in healthy volunteers and in neurological patients after a single intravenous injection.

The pharmacokinetics of dihydroergotamine (DHE) was studied in healthy volunteers (n = 6) and in neurological patients (n = 12). After a single 1.0 mg intravenous injection (n = 5) DHE quickly disappeared (T 1/2 beta = 32.9 min, Vdss = 0.33 liter/kg, Cltot = 1055.7 ml/min). In saliva (dose 1.0 mg, n =6) and cerebrospinal fluid (dose 0.5 mg, n =12) there were no measurable amounts of DHE after a single i.v. dose. The 32-h cumulative urinary excretion was 0.02-0.04% of the 1.0 mg intravenous dose. In one subject renal (0.18 ml/min) and extrarenal (692.9 ml/min) clearance of DHE was calculated. According to our results DHe is probably eliminated mainly by hepatic metabolism. The pharmacokinetic properties of DHE indicate a fast clinical response without a cumulative action.

Adult↗
PubMed1978

Craniofacial and dental study of mulibrey nanism.

Dental and craniofacial features of 17 children and young adults suffering from the recently discovered mulibrey nanism syndrome are described and discussed. The present data do not allow any definite craniofacial typification of the syndrome. However, several findings suggest that we may be dealing with persistence of infantile structural relationships in the craniofacial area.

Adolescent↗
PubMed1976

A note on craniofacial sutural growth.

The paper presents and discusses some features of sutural structures. Fibre orientation in sutures seems to be quite variable and associated with minute local growth phenomena. Trabecular patterns in bones, reflecting growth, appear to support the idea of the outside determination of growth. The bevelled and interdigitated structures seen in many sutures may be interpreted as an expedient solution to the problem of fast growth.

Animals↗
PubMed1975

Adaptation of the mandible in children with adenoids.

In a sample of lateral x-ray cephalograms of children with obstructing adenoids, a dorsal rotation of the mandibular ramus was found to characterize the facial skeleton. The mandibular body and the condylar process were not correspondingly rotated. The findings suggest that dorsal rotation of the mandible occurring in association with various pathologic processes could always be primarily a response to an encroachment of the pharyngeal space. A possible involvement of the clivus region, to a minor degree, was also indicated. The need for "tailormade" cephalometric methods in studies of specific problems is stressed.

Adenoidectomy↗