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Biomedical subjects

K Koshida

Publications and source records attributed to K Koshida.

69 records · Page 4Linked to original sources
PubMed1985

Pseudouridine and uridine in normal kidney and kidney cancer tissues.

The tissue concentrations of a modified nucleoside, pseudouridine, and a normal nucleoside, uridine, were measured with high-performance liquid chromatography. Human kidneys were obtained from five patients with renal cell carcinoma and divided into a noncancerous part and a cancerous part. The pseudouridine concentration in the cancerous part of the kidneys ranged between less than 2-2.8 nmoles/g and in the noncancerous part 4.3-19.4 nmoles/g (mean 10,9 nmoles/g). The uridine concentration in the cancerous and noncancerous parts of the kidney ranged between 19.6-179.1 nmoles/g (mean 110.7 nmoles/g) and 117.5-235.6 nmoles/g (mean 191.5 nmoles/g), respectively. The pseudouridine concentration appeared to be approximately seven times higher in the noncancerous part as compared to the cancerous part of the kidney. In the case of uridine, the difference was less pronounced.

Carcinoma, Renal Cell↗
PubMed1985

[Hyperthermic perfusion therapy using peplomycin for bladder cancer].

Hyperthermic intravesical perfusion therapy using peplomycin (40 micrograms/ml) in distilled water at 43 degrees C as a perfusate was performed for 2 to 3 hours in 18 patients with superficial bladder tumors and 2 with deep bladder tumors. The therapeutic efficacy was determined by cystoscopy, ultrasonography and/or CT scan. Complete and partial tumor regression was obtained in 1 and 3 of the 18 patients, respectively. There was no tumor regression in the 12 patients. Most of the patients studied had bladder discomfort such as irritation, urinary frequency and so on, during and/or after perfusion. None of the patients developed acute pyelonephritis.

Aged↗
PubMed1985

[PPD, PHA and Su-PS skin tests in genitourinary malignancies].

PPA, PHA and Su-PS skin tests were performed on 152 urogenital malignancy patients and the results obtained were analysed in terms of clinical course. The survival rate of 86 patients showing a positive response to the PPD skin test was significantly higher (P less than 0.005) than that of 65 patients showing a negative response to the PPD skin test. Among the 33 renal tumor patients, the positive rate of the 10 patients with stage I tumors to PPD skin test was significantly higher (P less than 0.05) than that of the 13 patients with stage IV tumors. In 68 bladder tumor patients, the response rate to PPD skin test in 47 patients with a low stage tumor was significantly high (P less than 0.05) compared with that in 21 patients with a high stage tumor. Out of 47 patients who died during the 84-month observation period, 10 (21.7%) and 3 (13.3%) showed a response change from negative to positive, in the PPD test and Su-PS test, respectively. It was assumed that 32 of the 46 patients (69.6%), 4 of the 6 patients (66.7%) and 17 of the 23 patients (73.9%) submitted to the PPD, PHA and Su-PS tests, respectively, showed a negative response at the time of their death.

Carcinoma, Renal Cell↗
PubMed1979

[Superimpose of images by appending two simple video amplifier circuits to color television (author's transl)].

Images are very useful to obtain diagnostic informations in medical fields. Also by superimposing two or three images obtained from the same patient, various informations, for example a degree of overlapping and anatomical land mark, which can not be found in only one image, can be often found. In this paper characteristics of our trial color television system for the purpose of superimposing X-ray images and/or radionuclide images are described. This color television system, superimposing two images in each different color consists of two monochromatic vidicon cameras and 20 inches conventional color television in which only two simple video amplifier circuits are added. Signals from vidicon cameras are amplified about 40 dB and are directly applied to cathode terminals of color CRT in the television. This system is very simple and economical color displays, and enhance a degree of overlapping and displacement between images. As one of typical clinical applications, pancreas images were superimposed in color by this method. As a result, size and position of pancreas was enhanced. Also X-ray image and radionuclide image were superimposed to find exactly the position of tumors. Furthermore this system was very useful for color display of multinuclides scintigraphy.

Amplifiers, Electronic↗
PubMedDate not supplied

Myelolipoma of the adrenal gland found incidentally during abdominal ultrasound and computed tomography examinations.

We report a case of adrenal myelolipoma found incidentally during abdominal ultrasound (US) and computed tomography (CT) examinations for hypertension. The patient was a 34-year-old woman with a history of hypertension. In June 1992, she complained of dizziness and easy fatigability and went to a hospital, where she was diagnosed as very hypertensive. She was hospitalized for further examinations. Abdominal US and CT incidentally revealed a right adrenal tumor. The tumor was visualized as a hyperechoic mass on US and an inhomogeneous low density mass with inner fat density and focal calcification on CT. Magnetic resonance (MR) imaging visualized the tumor as a high signal intensity mass on both T1- and T2-weighted images. Since the tumor was relatively large and the possibility of malignancy could not be completely excluded, resection of the tumor was performed. The resected tumor, which measured 5.2 x 3.8 x 2.5 cm, was located in the right adrenal medulla and was composed of mature fat cells and bone marrow elements, with all the developmental stages of hematopoietic cells. Small areas of fresh hemorrhage and calcification were found. The fat cell component showed focal myxoid change, but there were no immature or atypical cells. These features were consistent with myelolipoma. The clinical and pathologic features of adrenal myelolipoma are discussed.

Abdomen↗