Epidermal lysosomes and ultraviolet light.
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Biomedical subjects
Publications and source records attributed to K Konrad.
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The phagocytosis of latex beads by epidermal cells is proposed as a model for stludies on melanosome kinetics within the epidermis. Large latex beads (0.8 micrometer) are ingested singly, whereas, small beads (0.1 micrometer) are taken up in groups, results showing that the uptake mechanism depends on the size of thze indlividual particles. This size-dependency may explain the different distribution patterns of melanosomes and thus the differences of skin color in the Caucasoid and Negroid races.
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Two cases of spindle cell tumors are presented which by histopathology, histochemistry and electron microscopy were classified as desmoplastic melanoma and neurotropic melanoma, respectively. The striking similarity of these tumors has to be regarded as further evidence of the close histogenetic relationship of desmoplastic and neurotropic melanoma.
The histological findings in needle biopsy specimens from 35 patients suffering from chronic exudative synovitis of the knee were compared with the clinical data and with the results of chemical synovectomy carried out after the needle biopsy. The investigations suggest that in cases with the pronounced histological changes less improvement can be expected from chemical synovectomy than in cases with slighter histological changes.