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Biomedical subjects

K Kono

Publications and source records attributed to K Kono.

At least 217 records · Page 12Linked to original sources
PubMed1985

Pneumatosis cystoides intestinalis and trichloroethylene exposure.

A case-control study was carried out to assess the association between pneumatosis cystoides intestinalis (PCI) and working conditions, including occupational exposure to organic solvents. Thirteen patients with primary PCI were individually matched with controls by sex, age, and admission year. It was found that there was a close association between the development of primary PCI and occupational exposure to trichloroethylene (TCE). Twelve of 13 patients with PCI (92.3%) were found to have been exposed occupationally to TCE, and the healing and recurrence of PCI in these patients substantially paralleled the profile of their occupational exposure to TCE. Two pairs of patients with PCI had been working in the same factories, where they had degreased camera lenses with TCE. These results suggest that chronic exposure to TCE could be one of the etiological factors in PCI.

Adult↗
PubMed1985

Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sjögren's syndrome.

Fibronectin, a high molecular weight plasma protein, was applied locally to 12 patients with keratoconjunctivitis sicca of Sjögren's syndrome refractory to conventional treatment. All patients had ophthalmologically proved keratoconjunctivitis sicca of unknown etiology and were suffering from severe eye symptoms. Fibronectin was purified from autologous plasma and administered to the patients as tear drops 3 times a day. All patients responded to the therapy with fewer subjective symptoms and decreased fluorescein staining. All but 3 responded to the therapy as judged by rose bengal test. No adverse effects were encountered. We conclude that local application of fibronectin may benefit patients with keratoconjunctivitis sicca of Sjögren's syndrome.

Fibronectins↗
PubMed1984

Arterial chemoembolization of hepatocellular carcinoma with mitomycin C microcapsules.

Chemoembolization by selective intra-arterial infusion of mitomycin C in microcapsule form exerts potential therapeutic effects through infarction and prolonged activity. Of 20 patients with inoperable hepatocellular carcinoma (HCC) treated with one or more courses via a hepatic arterial catheter, a change in tumor size could be measured in 16. Measurable tumor regression amounting to greater than 50% was shown in 6 patients (38%), 25-50% in 3 (19%), and less than or equal to 25% in 6 (38%), while tumor increased in 1. Serum alpha-fetoprotein, which was greater than 300 ng/ml before treatment in 13 patients, clearly fell after treatment in 10 (77%). The survival rate at 3, 6, and 12 months after treatment was 75%, 65%, and 24%, respectively, for all patients, and 92%, 85%, and 38% in 11 patients without a tumor cast in the portal vein or its major branches. Systemic toxicity was mild, and all patients tolerated treatment well. These results indicate that chemoembolization with mitomycin C microcapsules is a useful palliative measure for treatment of inoperable HCC.

Adult↗
PubMed1984

Clinical significance of serum alpha-fetoprotein in patients with liver cirrhosis.

The clinical significance of serum alpha-fetoprotein (AFP) was studied in 114 patients with liver cirrhosis, who were followed for more than one year. Out of 114 patients, serum HBs antigen (HBsAg) was positive in 49 (43%). The mean follow-up period was 4.3 years (from 1 to 13 years). Serial determinations of AFP by RIA were performed once a month in all patients. The pattern of serial changes of AFP levels could be divided into three characteristic types: 1) fluctuation of AFP levels to greater than 20ng/ml was observed in 39 cases (Type I); 2) a transient rise of AFP levels to greater than 50ng/ml was observed in 20 cases (Type II); 3) in the remaining 55 cases, AFP levels were always less than 20ng/ml. During the follow-up period, liver cell carcinoma (LCC) developed in 29 cases (25%) and hepatic failure in 11 cases (10%). The incidence of LCC was significantly higher in Type I (18/39, 46%) than in Type II (3/20, 15%) and Type III (8/55, 15%). It is concluded that cirrhotic patients with fluctuation of AFP levels should be included in the high-risk group for LCC.

Adult↗
PubMed1984

Significance of HB virus infection in an area of Japan with high incidence of liver cirrhosis and hepatocellular carcinoma: an analysis of consecutive studies among inhabitants of Tomié-Town, Goto Islands.

In an attempt to clarify the relationship of liver cirrhosis and hepatocellular carcinoma, we have carried out investigations at an area where both these diseases develop frequently. 1) We studied the incidence of HBsAg and its antibody in 3521 inhabitants of Tomié-Town in the Goto Islands; 5.5% proved to be positive for HBsAg and 22.0% positive for anti-HBs. 2) In the HBsAg-positive group, the incidence of hepatomegaly and abnormal liver function were significantly higher than those in other groups. 3) In relation to HBsAg, anti-HBs and histological abnormalities of the liver, positive HBsAg was detected in one subject with hepatocellular carcinoma associated with liver cirrhosis, six of nine with liver cirrhosis, and four of 11 with chronic hepatitis. A positive antibody was found in one subject with liver cirrhosis and four with chronic hepatitis. Thus, HB virus infections was closely associated with latent liver disease in Tomié-Town.

Adolescent↗
PubMed1984

Tumor/serum ratios of alphafetoprotein and radioimmunolocalization of primary liver cancer.

Twenty six patients with primary liver cancer (PLC) were injected with 131I-labeled antibodies to alphafetoprotein (AFP). Each patient was tested by external photoscanning, 24 and 48 hours after injection. Positive imaging in the tumors was obtained in only 50 percent of patients. Serum AFP levels did not correlate with the radioimmunolocalization results. In 15 patients with PLC, concentrations of AFP in the tumors and sera were determined simultaneously. Although tumor AFP concentrations correlated significantly with serum AFP levels, tumor/serum AFP ratios differed greatly among tumors, indicating that there exists a dissociation between the production and the secretion of AFP. In 8 patients in whom the measurement of serum and tumor AFP concentrations and radioimmunolocalization were performed, tumor/serum AFP ratios correlated significantly with the results of radioimmunolocalization. This suggests that a high tumor/serum AFP ratio is important for the detection of PLC by radioimmunolocalization with antibodies to AFP.

Carcinoembryonic Antigen↗