[Schizophrenia-like psychosis following administration of propranol].
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Biomedical subjects
Publications and source records attributed to K Koehler.
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First-rank symptoms of schizophrenia, such as thought insertion, thought broadcasting, "made" volition, and delusional perception, were introduced for purposes of diagnosis into a German university clinic. Such "Schneiderian" criteria were evaluated in 210 case records. Ratings employed formal definitions. Of 210 records examined, 69 (33%) of the schizophrenic patients had first-rank symptoms. The frequency of finding such symptoms in a group of schizophrenics is compared to other reports. There are considerable differences in frequency of individual symptoms as well as total number of such symptoms across centers, but the use of precisely agreed on definitions of first-rank symptoms may lead to better agreement.
The general importance of paying attention to symptomatology in psychiatry is stressed. Research in this area has been advanced by modern psychopathometric methods. A renewal of general interest in the "classical" symptomatology of the older German authors is also shown by research involving Kurt Schneider's first rank symptoms of schizophrenia in England and the USA. Important papers concerned with this latter trend are discussed.
Most earlier studies and all studies on national samples in Scandinavia and in England and Wales have shown that schizophrenics have a significant excess of births in the early months of the year when compared with the expected distribution of the normal population. The present German study, carried out on schizophrenic patients diagnosed in a strongly Kurt Schneider--oriented clinic, in contrast to almost all other authors, demonstrated no such significant overrepresentation of births in the winter months. Thus, the findings of Danneel's (1973) German report, also utilizing Schneider-diagnosed schizophrenics, seem, at least for the present, to be confirmed.
"Thought insertion" is one of Kurt Schneider's first rank symptoms of schizophrenia. Earlier, Karl Jaspers had made a finer distinction, differentiating between "thought insertion in a narrower sense" and "made thoughts." However, most German and English writers have dispensed with the Jasperian criteria for this differentiation and consequently their use of the term "thought insertion" is broader. Such authors, including Kurt Schneider and Weitbrecht, usually speak of "thought insertion", "made thoughts", and "influencing of thoughts" as if they were identical phenomena. In contrast, Jaspers' differentiation offers us the possibility of more clearly distinguishing such symptoms and thus his distinction should not be neglected. Furthermore, the Jasperian criteria can be logically and usefully extended to all "made and passivity experiences" enabling one to recognise four aspects of such phenomena. Some general differential diagnostic considerations with respect to "thought insertion" are then presented.
It is a neglected psychopathological fact that Schneider clearly differentiated the delusional notion linked to a perception ("wahrnehmungsgebundener Wahneinfall") from the delusional perception ("Wahnwahrnehmung"). When this distinction is not taken into account, it is very likely that the probability of a false positive rating for the delusional perception is increased. A possible practical aid to help operationalize the differential "diagnosis" between these two symptoms is offered. The section on "delusional" phenomena in Wing's present-state examination is then discussed in the light of these distinctions.
Most earlier studies and all recent studies on national samples have shown that compared with live births in the control population, schizophrenic patients have a significant excess of birth rates in the winter or early months of the year. In contrast, only some of the early research efforts and only some of the national studies (in England and Wales as well as for certain decades in Sweden) have demonstrated that the same holds true for patients with affective psychosis. The present German study, carried out on affective disorder diagnosed in a strongly Kurt Schneider-oriented clinic, found (as did most Scandinavian research on national samples) that there was no significant overrepresentation of births in the winter or early months of the year for all types of affective disorder, neurotic as well as psychotic. Thus, the findings on Schneider-diagnosed affective disturbances were similar to those on Schneider-diagnosed schizophrenia reported elsewhere.
A woman aged 20, first presenting with what appeared to be hysterical blindness as part of the syndrome of hysterical pseudo-dementia, soon showed the picture of speech-prompt catatonia, one of the subtypes of chronic schizophrenia described by Karl Leonhard. However, within a short time the neurological, EEG and laboratory findings indicated that the condition was one of subacute sclerosing panencephalitis.
The Chair of the University Nervenklinik in Homburg/Saar was held by Klaus Conrad from 1949-58 and by H.-H. Meyer, a former pupil and colleague of Kurt Schneider, from 1962-72. As the catchment area and admission policy of the clinic remained substantially unchanged throughout, comparison of the relative proportions of all admissions allocated to different diagnostic categories in 1949-58 and 1962-72 can be used to elucidate the similarities and differences between Conrad's and Schneider's diagnostic criteria. The results of this comparison indicate that Schneider's concept of schizophrenia was broader than Conrad's, and his concept of manic-depressive depression more restricted. More detailed comparisons are complicated by differences in nomenclature and in the varieties of functional mental illness recognized in the two periods. However, it seems that Conrad's concept of mania was wider only when the atypical schizophrenia-like psychoses diagnosed during the Conrad era were added to the Conrad-oriented cases of mania; when this was not done, the Schneiderian concept of mania was broader.
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Although rates for invasive cervical cancer have declined over the past twenty years among Alaska Native women, they continue to show high rates of pre-invasive cervical lesions (cervical intraepithelial neoplasia, or CIN). We investigated risk factors for CIN II/III among Alaska Native women in a pilot case-control study. Cases (n = 26) included women with biopsy-proven CIN II/III, while controls (n = 52) had normal cervical epithelium. The strongest risks associated with CIN II/III were HPV infection of any type (Crude Odds Ratio [OR] 8.4, 95% Confidence Interval [CI]: 2.9-29.4), HPV 16 infection (OR 40.8, 95% CI: 9.4-176.4), and a family history of cervical dysplasia (OR 3.9, 95% CI: 1.3-11.3). We also found that use of depot-medroxy progesterone acetate was associated with CIN (OR 3.0, 95% CI: 1.1-8.5). A larger investigation would be necessary to allow adequate evaluation of these, and other, risk factors for CIN among Alaska Native women.