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Biomedical subjects

K Kochsiek

Publications and source records attributed to K Kochsiek.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Influence of propranolol and digoxin on the leftventricular pressure-volume-relation of the guinea pig (author's transl)].

Leftventricular parameters of pressure, volume and contractility were recorded in the guinea pig treated with propranolol and digoxin. Propranolol shifts the isovolumetric pressure-volume-relation to higher enddiastolic volume. Pressure, rate of pressure rise, and heart rate considerably decrease. Cardiodepression of high-dose propranolol treatment is reversed in part by digoxin. Conclusions for application of beta-blockers, especially in imparied ventricular function, are discussed.

Animals↗
PubMed1980

[Tl-201-imaging as a follow-up method after left ventricular aneurysmectomy (author's transl)].

Thallium myocardial scanning was performed in 30 patients after aneurysm resection of left ventricle. The aim of the study was to try an assertion about the completeness of adaptation of the marginal zones of aneurysm and about the postoperative reduction of left ventricular size. After standardization of size and distance of pictures we suggested quantification of dimensions of left ventricle by counting picture-points using a computer matrix. For that purpose left ventricle had to be deliminated exceptional distinctly from the background. That intention was realized by an interpolating background subtraction. Postoperatively an evident reduction of heart size, especially of ventricle cavity could be proved. Thallium myocardial scanning therefore seems to be suitable for postoperative supervision after aneurysm resection too.

Computers↗
PubMed1979

Noninvasive perfusion control by thallium-201 myocardial scintigraphy after coronary artery bypass surgery.

Thallium-201 myocardial scintigraphy, which has been shown accurate in the assessment of myocardial perfusion, was employed in the evaluation of 34 patients after coronary artery bypass surgery. In 28 patients (82.4%), there was a clear correspondence in the postoperative studies between the defects shown on scintigraphy and the coronary artery stenosis documented by arteriography. Thallium imaging after coronary artery bypass revealed an increased or newly developed scintigraphic defect in eight of 10 patients with recurrent angina. Follow-up arteriography in these 10 patients revealed occlusion or stenosis of the bypass graft in five, perioperative myocardial infarction in two, and increased stenosis of a preoperatively less occluded artery in two. In 24 patients with postoperative clinical improvement or relief of angina, 201Tl scintigraphy revealed complete normalization of thallium uptake in three, improvement of uptake in 17, and unchanged uptake defects in four.

Adult↗
PubMed1979

Clinical significance of immunopathological findings in patients with post-pericardiotomy syndrome. II. The significance of serum inhibition and rosette inhibitory factors.

Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found in the first post-operative week in almost all patients; patients with complete post-pericardiotomy syndrome (PPS) still had these factors in the fourth postoperative week. The appearance of SIF correlated well with the intensity of the PPS. Persistence of SIF in eleven out of eighteen patients with clinically incomplete PPS reaffirms the probability that they had an 'immunologically' positive PPS. RIF was to be found in one third of the patients with complete or incomplete PPS and may be of prognostic value. The two factors were not identical.

Alpha-Globulins↗
PubMed1978

[Familial coincidence of hypertrophic cardiomyopathies and thyroxine-binding globulin deficiency (athyropexinemia) (author's transl)].

A twenty-five year old man was found to have simultaneous total deficiency of thyroxine-binding globulin ("thyropexin") and hereditary hypertrophic obstructive cardiomyopathy (HOCM). The thyroxine-binding capacity (RT3U), thyroid hormone levels, PB127I, PB131I and TBG (RIA) in serum were very low and TBG cap was zero. Trapping of radioiodine in the thyroid was enhanced. Clinically, the patient appeared euthyroid. The case seems to be similar to another one described earlier by Ingbar. An investigation of the family showed that in one uncle and two nephews of the patient thyropexin was absent whilst the mother, one sister and one female cousin had partial thyropexin deficiencies. One of these nephews also suffers from asymmetric septal hypertrophy (ASH), the mother of the propositus has a non-obstructive hypertrophic cardiomyopathy (HCM).

Adult↗
PubMed1978

[Computer-assisted 201Tl myocardial scintigraphy in the routine diagnosis of coronary heart disease (author's transl)].

The aim of the study was to evaluate the validity of 201Tl scanning for clinical routine use in the diagnosis of coronary heart disease. A computer-aided matrix with very high resolution displaying subtle color nuances was used. For semi-quantitative assessment a scale with 16 colors was applied. This permitted to differentiate between changes of intensity of 6.25%. Compared with the ECG on exercise no higher sensitivity or specifity of 201Tl scanning was found using coronary angiography as the reference method. When a typical angina pectoris and a pathological ECG on exercise was present, confirmation of the diagnosis of coronary heart disease by scanning was readily obtained. Moreover, in the event of equivocal findings in the ECG and of atypical chest pain scanning is helpful without having to resort to invasive methods. Additionally to the exercise ECG, the location of ischemic areas in the myocardium can be easily demonstrated by scanning. When angiography has shown unobstructed coronary arteries but the ECG is suggestive of scar formation, scintigraphy provides additional information regarding the diagnosis of coronary heart disease. It is also possible by scanning to delineate the tissue defect representing fibrotic areas. This is necessary for instance when aneurysmectomy is planned.

Adult↗
PubMed1976

[Classification of cardiomyopathiess (author's transl)].

Cardiomyopathies are functional disorders of the heart muscle which are not due to a mechanical overstrain or coronary circulatory disorder. They occupy a special place because they occur either from an unknown cause (primary cardiomyopathies) or in connection with a known primary disease or with infectious or toxic influences (secondary myocardiopathies) as generalized or circumscribed disturbances of the contraction process of the myocardial fibres. A classification can be made according to etiological and according to hemodynamic aspects.

Blood Pressure↗
PubMed1975

[Determination of serum-digitalisglycoside concentrations by radioimmunoassay before, during and after operations with extracorporal circulation (author's transl)].

In 13 adult patients serum-glycoside concentrations, renal glycoside elimination and endogenic creatinine clearance were determined before, during and in the first 4 days following the operation. A postoperative digitalis cumulation has not been seen. But there was a diminished digitalis tolerance in the immediate postoperative phase. Two patients got ventricular bigeminus. The low potassium values at the same time may possibly affect the sensitivity of digitalis.

Adolescent↗