Search PubMed⌕ Search

Biomedical subjects

K Koch

Publications and source records attributed to K Koch.

153 records · Page 9Linked to original sources
PubMedDate not supplied

Penetration of ceftazidime into human pancreas.

The use of antibiotics in patients with severe acute pancreatitis (stage II and III) is indicated since bacterial complications are the most common cause of death in these patients. In the present study the penetration of ceftazidime into pancreatic juice, into healthy and chronically inflamed pancreatic tissue as well as into necrotic regions in cases of severe acute pancreatitis was investigated. A peak concentration of 12.9 +/- 5.9 mg/l was found 60 min after intravenous administration of 35 mg/kg of the drug, which is 32% of the corresponding serum levels. Pancreatic tissue concentrations varied between 9 and 79% of the corresponding serum levels, depending on the stage of inflammation. After five days of antibiotic treatment with doses of 2 g t.i.d., concentrations between 1.8 and 6.9 mg/kg were detected even in pancreatic necroses. This suggests that sufficient antibacterial levels of ceftazidime were present in all pancreatic compartments analyzed following administration of common therapeutic dosages. Therefore, from a pharmacokinetic point of view, ceftazidime could be a potentially effective drug for the treatment of pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Acoustically evoked brain magnetic activity in normal and growth retarded fetuses during the third trimester of pregnancy].

The fetal magnetoencephalogram with a 31 chanal biomagnetometer made by Philips was measured in a fetal 1F-phase in 20 normotroph unimpaired and in 14 growth retarded fetuses with a birth weight < 5 percentile after completed 36th gestational week. Trough defined acoustic stimulations, which were applied over the maternal abdominal wall, it was possible to measure acoustic evoked cerebromagnetic field changes using a special computer programs. The registrated evoked cerebromagnetic field changes had a latence time of 112.8 +/- 18.4 ms in normotroph fetuses and 130.9 +/- 18.5 ms in hypotroph fetuses. The difference was significant (p < 0.01). The presented results lead to the conclusions that the fetal magnetoencephalography makes a differentiation between normal and disturbed fetal cerebral integrity possible.

Embryonic and Fetal Development↗