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Biomedical subjects

K Kletter

Publications and source records attributed to K Kletter.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Biphasic 201thallium scintigraphy after dipyridamole in mitral valve diseases (author's transl)].

The results of biphasic 201thallium scintigraphy after dipyridamole i.v. could neither prove nor exclude the presence of small focal lesions in the myocardium of 17 patients with mitral valve diseases. The frequent finding of a decrease in activity in the anterolateral myocardium is probably due to a relative increase in activity in the region of the inferior wall with superimposed areas of the papillary muscle and right ventricular myocardium. If the right ventricle is visualized in stress- or redistribution images, an increase in mean pulmonary artery pressure can be accepted. According to Cohen's criteria, a grade 2 or 3 virtually proves the existence of pulmonary hypertension, a grade 1 makes this finding rather probable. The possibility of pulmonary hypertension can not be excluded if the right ventricular myocardium is not visualized.

Adult↗
PubMed1980

[Radiation exposure in modified double-contrast examination of the intestine (author's transl)].

The radiation exposure of jejunum, skin and gonads during dynamic double contrast studies of the small intestine was measured by thermoluminescence-dosimetry. This radiological examination performed under fluoroscopic control, resulted in a higher dose of skin radiation than when applying conventional methods. The gonadal dose, however was not increased when small fields of view were used during fluoroscopy.

Female↗
PubMed1980

Evaluation of the 75Se-l-selenomethionine test for pancreatic disease. Studies on gel filtration.

Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) for 2 h. Duodenal juice was collected from a double-lumen Lagerlöf tube and the 75Se radioactivity measured. Gel filtrations on Sephadex G-50 were performed from samples of duodenal juice. Total duodenal radioactivity in pancreatic insufficient patients was significantly lower than in normal subjects 60-120 min after the start of the examination. When regarding the individual values of each subject an important overlap of normal and pancreatic insufficient persons could be observed. No difference in the gel filtration pattern was demonstrable between the two groups. From these results the use of 75Se-l-selenomethionine for diagnostic purposes in pancreatic diseases cannot be recommended.

Chromatography, Gel↗
PubMed1980

[Clinical significance of gamma camera renography in chronic renal insufficiency (author's transl)].

Gamma camera renography allows, together with renal imaging, an evaluation of individual renal function. For these examinations, J 123 orthoiodohippurate is preferred and most widely used. The results on patients with chronic renal insufficiency, including urologic and posttransplantation patients, are reported. Whereas the method is of clinical significance in evaluating posttransplantation complications and in assessing individual kidney function preoperatively in urology, as well as in monitoring therapeutic effects in the early period of renal disease, it is of limited diagnostic value in chronic renal insufficiency. In this latter regard, clinical and laboratory examinations are of primary importance.

Humans↗
PubMed1979

Comparison of two different biliary agents in healthy subjects and in patients with liver disease.

The kinetics of the iminodiacetic acids, dimethyl and diethyl IDA were studied in patients without and with liver disease. Diethyl IDA seems to be superior to dimethyl IDA in its diagnostic usefulness. It shows lower urinary excretion and a faster liver uptake, leading to more pronounced differences in liver peak time and in liver elimination half time and to faster visualisation of the gall bladder in patients with liver disease. The enterohepatic reabsorption is negligible as shown by enteral administration of the radiopharmaceutical and monitoring blood activity. Therefore it is not necessary to correct time activity curves of the liver for the IDA secreted into the gastrointestinal system. The most valuable diagnostic information with this substances may be gained in investigations on cholecystectomized patients with cholestasis.

Humans↗
PubMed1979

Radiation exposure due to 99mTc and 131I manipulated in syringes.

Dose rates around and at the surface of disposable polypropylene syringes of 1 and 2 ml volume filled with 99mTc and 131I solutions were determined by thermoluminescence dosimetry. Data for the efficacy of 0.5 and 1 mm lead shielding of 99mTc and for the dose contribution due to beta- -radiation from 131I are given.

Humans↗
PubMed1979

[Indication and value of erythrokinetic examinations in anemia].

As erythrokinetic studies are time consuming and costly, this technique should only be done to provide information which is unavailable through simpler tests. By means of discussion concerning the methodological procedure and obtainable information, the indications for erythrokinetic investigations with Cr 51 and Fe 59 are derived. Since the results should be interpreted together with the clinical and haematological findings, a close cooperation of the departments of nuclear medicine and haematology would be essential.

Anemia↗
PubMed1978

Irradiation therapy with 131I-6beta-iodocholesterol of metapyralone induced adrenal hyperplasia in rats.

Marked weight reduction of rat adrenals was observed after 131I-6beta-Iodocholesterol administration whether or not the animals were treated with metapyralone. Damage or even histologic changes of the adrenals have not been found. Though the radiation dose is high with the applied dose of 131-i-6-beta-Iodocholesterol and might limit or even prevent its application in the treatment of human adrenal disease, the influence of endogenous irradiation on rat adrenals is obvious and justifies further investigations.

Adrenal Gland Diseases↗
PubMed1978

[Pulmonary metastatic calcifications in malignant lymphoma demonstrated by imaging agents. Case report (author's transl)].

This report describes a patient with malignant lymphoma and hypercalcemic crises. A bone scan showed pronounced uptake of 99mTc-Methylene diphosphonate (MDP). This finding is thought to be due to metastatic lung calcification, which absorbs skeletal radiopharmaceuticals. The developement of metastatic calcifications in this case is most likely caused by phosphate applications to treat hypercalcemia. The mechanisms of formation and the detection of metastatic lung calcification with 99mTc-MDP are discussed.

Calcinosis↗
PubMed1978

[Scintigraphy of the adrenal glands].

The use of 6 beta-131I-Iodomethyl-Cholesterol as an adrenal imaging agent instead of 131I-19-Iodocholesterol has improved the szintigraphic visualization of the adrenals and radiation safety as well. Best results are obtained with respectively unilateral changes of the adrenals or with steroid producing tumors. Pheochromocytomas are diagnosed by decreased uptake of iodinated cholesterol by the adrenals. Possible therapeutic application of radiocholesterol in steroid producing tumors of the adrenals is discussed.

Adrenal Gland Neoplasms↗
PubMed1977

[The clinical relevance of scintigraphic adrenal imaging (author's transl)].

Labelled steroid precursors have been found to be valuable in scintigraphic imaging of localized adrenal disease or even in adrenal hyperplasia. Scanning procedures are non-invasive diagnostic methods and, in the case of the adrenals the images reflect anatomical as well as functional changes in the organs, constituting an advantage over angiographic methods. However, careful preparation of the patient, sophisticated technical prerequisites and a case-oriented programme of the procedure favouring either dexamethasone suppression, comparsion with phantom measurements adrenal profiles and/or multichannel analysis are necessary for the attainment of optimum results on scintigraphy.

Adrenal Gland Diseases↗
PubMed1977

[Improved scintigraphic imaging of the adrenals with 6beta-131I-iodomethyl-cholesterol (author's transl)].

Scintigraphic visualization of the adrenals is greatly improved after substitution of 131I-19-I-Cholesterol by 6beta-131I-Iodomethyl-Cholesterol which was first seen as a radiochemical impurity during the synthesis of 131I-19-Iodocholesterol. The interpretation of the scintigraphic imaging is further improved by application of a cross section through the visualized adrenals. In an animal experiment the radioactivity of the adrenals and to a less degree that of different tissues was found up to four times higher after injection of 6beta-131I-Iodomethyl-Cholesterol than with the applications of 131I-19-Iodocholesterol. The high affinity of the tissue for 6beta-131I-Iodomethyl-Cholesterol results in high radiation exposure of the patients. However, since less activity of 6beta-131I-Iodomethyl-Cholesterol is necessary for visualization of the adrenals the overall radiation is also less than with the application of 131I-Iodocholesterol. Higher stability of the labelled molecule is suggested to be responsible for improved scintigraphic imaging of the adrenals.

Adrenal Glands↗
PubMed1977

Humoral function of acute leukaemic blasts.

Leukamic blasts from 8 patients with different forms of acute leukaemia were investigated for their capability to produce colony stimulating factor. A second point of investigation was to detect inhibitory activity from the same blasts. The agar technique in its double layer modification was used with bone marrow from C57 Bl mice as target cell population. No single pattern of colony growth was observed. CSF production was absent or very low, when compared with CSF from normal mononuclear cells. However, blasts from 4 patients disclosed inhibition of colony growth. No certain relationship existed between the cytochemic type of leukaemia and the production of either activator or inhibitor of in vitro colony formation.

Acute Disease↗
PubMedDate not supplied

Influence of parenteral nutrition on serum levels of proteins in patients with Crohn's disease.

Parenteral nutrition (PN) is commonly used in the management of inflammatory bowel disease. Previously we reported about the serum protein levels in Crohn's disease before and after treatment with PN; in that study we found an increase of some indicators of nutritional status and a decrease of some acute phase reactants after treatment. We have now completed the trial determining the concentration of 19 serum proteins in 25 patients with Crohn's disease before and after treatment with PN and 8 wk thereafter. The concentration of albumin, retinol-binding protein, prealbumin, and transferrin were found to rise in parallel with the body weight during PN, whereas 8 wk after treatment only albumin and transferrin showed a further significant rise. alpha-1-Glycoprotein, alpha-2-chymotrypsin, alpha-1-antitrypsin, CRP, and haptoglobin decreased during and 8 wk after PN, alpha-1-glycoprotein, alpha-2-chymotrypsin, and alpha-1-antitrypsin showed a positive correlation to the Crohn's Disease Activity Index. The serum IgM-levels were found to be significantly increased during and after PN with a negative correlation to the Crohn's Disease Activity Index. Our data indicate that PN not only improves nutritional status in the active phase of Crohn's disease during therapy but reduces the grade of inflammatory activity during and even after treatment with PN.

Adolescent↗