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Biomedical subjects

K Klemm

Publications and source records attributed to K Klemm.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Indication, technic and results using the external fixator in infected fractures and infected pseudarthrosis].

Infected pseudo-arthrosis is the dreaded combination of chronic osteomyelitis and instability at the fracture site. Treatment consists in radical removal of sequestered bone and alloplastic implants, temporary implantation of Septopal chains for high-dose local antibiotic therapy and re-osteosynthesis with external fixator. The external fixator of Raoul Hoffmann is preferred because of its unlimited versatility. A total of 131 patients were treated in accordance with the method described. In 90.1% of the cases bone consolidation was achieved, and in 89.3% chronic osteomyelitis subsided.

Adolescent↗
PubMed1982

[The fall of Icarus or the seriously injured young motorcyclist (author's transl)].

During 1979 70 motorcyclists were treated in the Department of Traumatology of the "Berufsgenossenschaftliche Unfallklinik" Frankfurt/Main. The psychological reasons of the motorcycle-boom and the consequences are compared. The psychic status of these young motorcyclists was different from that of other patients. An analysis of the data showed that in 24.3% the accident occurred on the way to work or to school; 75.7% of the accidents happened during a pleasure-trip. 58.6% of the motorcyclists suffered injuries with permanent sequels. The different types of permanent damage are described. Based on two case reports the arising costs are analysed.

Accidents, Traffic↗
PubMed1981

[Synthesis and physico-chemical properties of lonazolac-Ca, a new antiphlogistic/antirheumatic agent].

Calcium-[3-(p-chlorophenyl)-1-phenylpyrazole-4]-acetate (Lonazolac-Ca, active principle of Irritren) is a new antiinflammatory/antirheumatic agent whose synthesis and physico-chemical properties are described. The physical parameters measured (pKa, partition coefficient P, saturation concentration Cs, surface activity, protein binding) are held against the corresponding values of indomethacin, diclofenac, and phenylbutazone. The size of the permeability coefficient PM of the passive transport through artificial phospholipid collodion membranes as well as the invasion curves calculated from PM indicate a good absorption of lonazolac in man.

Acetates↗
PubMed1979

[In vitro method for estimation of enteral absorption of clanobutin and other drugs].

Two models have been developed for the determination of in vitro absorption of 4-[4-chloro-N-(4-methoxyphenyl)-benzamidol]-butyric acid (clanobutin) and other agents. Permeability coefficients PM are obtained on artificial phospholipid collodion membranes which permit calculation of absorption coefficients k1 for anticipated human enteral absorption with consideration of physiological parameters. At a pH of 7--8 (small intestine) in particular, k1 shows good agreement with in vitro absorption determined in swine intestine and absorption constant ka derived from pharmacological studies in man. The kinetic absorption model simulates gastro-intestinal transport of the substance as well as local changes in pH. It allows calculation of anticipated human gastric (pH 3) and intestinal (pH 7.5) absorption rates with k1 for different gastric filling volumes. The calculated invasion curves are held against invasion curves calculated from pharmacokinetic studies in man. The comparison shows that all invasion curves calculated according to the kinetic absorption model for gastric filling volumes of 125--1000 ml are within the 95% confidence range; very good agreement exists above all with filling volumes of 125--250 ml. The prognostic value of permeation studies on artificial phospholipid collodion membranes and of the use of the kinetic absorption model in drug design is demonstrated by corresponding studies with chenodesoxycholic acid, indometacin, and clofibrinic acid.

Absorption↗
PubMed1979

[Gentamicin-PMMA-beads in treating bone and soft tissue infections (author's transl)].

Temporary implantation of gentamicin-PMMA-beads and -chains provides a most-effective local antibiotic therapy as supplementary and consecutive treatment after surgical procedures executed in bone and soft tissue infections. The broad spectrum antibiotic gentamicin is gradually released from the PMMA beads in high doses, thus ensuring local concentrations of the antibiotic which never can be achieved by systemic application of the same antibiotic. Operative technique and advantages of this new way of local antibiotic therapy are explained. 128 patients were treated for different manifestations of chronic osteomyelitis in 1976. The chronic bone infections subsided completely in 91,4% of the patients, but 11 reinfections were observed within 6 to 24 months after termination of treatment. In 6 of those 11 cases this re-infection was caused by sequestered bone particles which had been overlooked.

Abscess↗
PubMed1978

[The results of experimental and clinical use of Gentamycin PMMA balls (author's transl)].

Authors describe a new method of treatment for bone and soft tissue infections using polymethyl methacrylate balls containing Gentamycin. Advantages of this method can be summarized in 3 points: 1. From the patients point of view saving the rinsing-sucking drainage, early mobilisation etc. 2. From nursing point of view a significant facilitation of the patient's care. 3. From the hospital management's point of view: improved hygienic conditions by eliminating the possible infections related to a rinsing-sucking wet system. Cutting down hospital expences both by abbreviation of the time of hospitalization and saving on expensive antibiotics.

Administration, Topical↗
PubMed1977

[Osteosynthesis for infected femoral pseudarthroses using the interlocking nail. 31 case reports (author's transl)].

31 cases of infected pseudarthrosis of the femur were re-osteosynthesized with the interlocking nail. Bony consolidation was obtained in 26 patients, in all cases the chronic osteomyelitic infection subsided with removal of the nail. Pseudarthrosis persisted in 3 cases, after removal of the nail the patients could walk with a walking splint. In one of this group bony consolidation was obtained after repeated interlocking nailing. Persisting pseudarthrosis and infection was the indication for amputation in 2 cases.

Adolescent↗
PubMed1977

[Synthesis and physico-chemical properties of the antihypertensive agent urapidil (author's transl)].

6-(3-[4-(o-Methoxyphenyl)-1-piperazinyl]-propylamino)-1,3-dimethyluracil (Urapidil, Ebrantil) is a new antihypertensive agent whose synthesis and physico-chemical properties are described. The size of the permeation constant KD of the passive transport through collodion-lecithin membranes and the value of the partition coefficient P in the neutral area indicate a good absorption and uniform distribution of the substance in the organism.

Antihypertensive Agents↗