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Biomedical subjects

K Kiyota

Publications and source records attributed to K Kiyota.

35 records · Page 2Linked to original sources
PubMed1992

[Epidemiology of non-ulcer dyspepsia (NUD) in Japan].

The purpose of this study is to investigate the incidence of NUD in Japan and to describe the clinical presentation of NUD. The population of this study consisted of the patients initially visited to our gastroenterology clinic during the period of one year from Feb. 1990 to Jan. 1991. Out of the total population, 106 patients with dyspepsia were suspected of NUD according to the definition of AGA, and have received the endoscopy and ultrasonography to find the existence of organic disease. While 50 cases presented organic diseases (19 peptic ulcers, 16 gastritis, 7 carcinoma, 4 gall stone, 4 esophageal disease), 56 cases were with no organic diseases and were regarded as NUD. NUD was more common in younger generation and was especially so in women under 40 years old. There was no significant difference in symptoms between NUD and organic diseases. On the other hand, peptic ulcer disease was frequently associated with sever epigastralgia, and smoking habit as a external factor, while abdominal fullness was predominant feature observed in NUD.

Adolescent↗
PubMed1987

Fundamentals of endoscopic laser therapy (ELT) for G.I. tumors--new aspects with endoscopic ultrasonography (EUS).

The possibility of employing endoscopic laser therapy (ELT) to cure early gastric cancer is discussed from the viewpoint of using endoscopic ultrasonography (EUS). Using EUS the digestive tract wall was seen as a 5-layered structure corresponding to the histological layers. On the basis of this layered structure of the gastric wall, the depth of cancer invasion and the results of laser treatment were evaluated. In 128 cases of gastric cancer examined by EUS and confirmed histologically, when the depth of cancer invasion was classified as mucosal, submucosal, muscularis propria, and deeper-than-subserosal invasion, the accuracy rate was 80%. In 26 cases of early gastric cancer, in the EUS images of the lesions before and after ELT, a lack of the gastric wall caused by the laser irradiation was observed. Furthermore, in the long-term follow-up study using EUS, the residual growth of the extraluminal cancer was detectable. EUS is one of the most promising methods for the evaluation of curative laser treatment of early gastric cancer.

Gastric Mucosa↗
PubMedDate not supplied

The diagnosis of submucosal tumors of the stomach by endoscopic ultrasonography.

The clinical value of endoscopic ultrasonography (EUS) in the diagnosis of submucosal tumors (SMTs) of the stomach was examined. We used echo endoscopes with a 7.5 or 10.0 MHz radial-scan transducer made by Olympus Co. Ltd. EUS was carried out on 80 patients with SMTs of the stomach including 54 cases confirmed histologically (24 cases of leiomyoma, 3 of leiomyosarcoma, 12 of cysts, 7 of aberrant pancreas, 4 of lipoma, 2 of carcinoid, and 3 of other diseases). Fifty-nine patients with extraluminal compression were detected by endoscopy and/or x-ray examination. We examined the effectiveness of EUS based on our analysis of the gastrointestinal tract wall seen in the EUS image as a five-layered structure corresponding with that of the histological layers. As a result, SMTs and extragastric compression were easily distinguishable in the EUS images of the lesions. The size, location, and origin of the SMTs could be detected. From the location of the SMT in the five-layered structure seen in the EUS image we could predict its histological nature. Thus, EUS was a most valuable method not only in the diagnosis of intramural and extramural SMTs but also in the detection of extragastric compressive lesions and organs.

Gastric Mucosa↗
PubMedDate not supplied

Triple therapy with omeprazole, amoxicillin and clarithromycin is effective against Helicobacter pylori infection in gastric ulcer patients as well as in duodenal ulcer patients. Results of a randomized controlled trial in Japan.

BACKGROUND/AIMS: There have been few reliable published studies permitting assessment of therapeutic regimens for Helicobacter pylori infection in gastric ulcer (GU) patients. The aim of the present study was to evaluate the efficacy of omeprazole-based dual and triple therapy regimens, both including clarithromycin, for the cure of H. pylori infection in active GU and duodenal ulcer (DU) patients. The study was conducted in Japan, a country in which GU is more prevalent than DU. METHODS: Two hundred and thirty-four consecutive peptic ulcer patients (GU: n = 124; DU: n = 103; GDU: n = 7) suffering from H. pylori infection were randomly treated with either omeprazole 20 mg b.i.d. + amoxicillin 500 mg q.i.d. + clarithromycin 400 mg b.i.d. (OAC) or with omeprazole 20 mg b.i.d. + clarithromycin 400 mg b.i.d. (OC) for 14 days. H. pylori infection was evaluated by histology and culture from antral and corpus biopsies 6 weeks after completing antimicrobial therapy. RESULTS: Follow-up data were available in 202 patients. The cure rates of H. pylori infection in GU patients were 83.9% (47/56) with OAC and 59. 2% (29/49) with OC. Corresponding rates in DU patients were 91.5% (43/47) and 70.5% (31/44), respectively. The cure rates with OAC were significantly higher than those with OC (p < 0.001, chi2 test). The cure rates in GU patients were lower than those in DU patients for both regimens, but these differences were not statistically significant. Side effects were generally mild and did not interfere with compliance. One patient in the OAC group and 2 patients in the OC group complained of severe side effects that led to therapy discontinuation. CONCLUSIONS: Triple therapy with omeprazole, amoxicillin and clarithromycin is a safe and effective regimen for the cure of H. pylori infection in GU patients as well as in DU patients. We recommend this triple regimen as a first-line treatment in all patients with peptic ulcers associated with H. pylori infection in Japan.

Adolescent↗