A case of aspergillotic meningoencephalitis associated with trigeminal neuralgia was reported. The patient, a 41-year-old female, was admitted to our hospital on Nov. 20, 1977 with the chief complaint of right trigeminal neuralgia. On admission right facial paresthesia and right abducens palsy were found. The skull x-ray and tomogram showed enlargement of the right superior orbital fissure. Ct scan revealed an irregular high density around the right superior orbital fissure. The examination of spinal fluid showed 75 mg/dl protein, 72 mg/dl sugar and 11 cells. A biopsy of the mass and trigeminal rhizotomy were performed on Dec. 21, 1977. Microscopically, the specimen was composed of nonspecific granulomatous inflammatory tissue. Thereafter, loss of visual acuity, total ophthalmoplegia and facial paresis gradually appeared on the right side with high fever elevation. Immunologically, peripheral blood lymphocytes responded normally to PHA and PWM, but numbers of lymphocytes showed a tendancy of decrease with deterioration. On the other hand, serum IgG and IgM levels were rather increased. CT scan showed that an irregular high density mass extended to the right orbital apex and the pterygoid fossa. Spinal fluid revealed 260 mmH2O pressure with 76 mg/dl protein, 55 mg/dl sugar and 293 cells, but no organisms were demonstrated. Four months after the operation, swelling of the right subtemporal region became remarkable, in which region a puncture revealed much pus retention, and Aspergillus fumigatus was cultured from the aspirated pus. The patient became comatose and died on May 20, 1978. Autopsy showed thick, yellowish green pseudomembranes covering from the right temporal tip to the basal cistern. The both of cerebral hemispheres were swollen and revealed multiple small softenings all over the brain. Small hemorrhage occupying the right temporal subcortex and microabscess located in the left thalamus were also seen. Microscopical examination disclosed that the pseudomembrane was composed of the necrotizing suppurative inflammation with branched septate hypha of Aspergillus. There have been a few reports of aspergillotic meningoencephalitis associated with trigeminal neuralgia and enlargement of the superior orbital fissure like this case. Some discussion was made on the importance for the diagnosis of aspergillosis to perform fungal culture and histological examination of materials obtained from the inflammatory site, and immunological data of this case was also presented.

Adult↗

PubMed1981

Pharmacokinetics of a new water-soluble nitrosourea derivative (ACNU) in human gliomas.

The pharmacokinetics of a newly developed water-soluble nitrosourea derivative (ACNU) following a single intravenous injection was investigated in 11 patients with gliomas. A major portion of ACNU was excreted within 2 hours. The distribution rate was very fast, and the elimination rate tended to be slow. More than 50% of ACNU moves into the tissue compartment. ACNU tended to move into glioma tissue well. The ACNU level in glioma tissue was above 1.0 microgram/gm 30 to 60 minutes ater injections. ACNU was detected at a higher concentration in malignant gliomas than in benign gliomas. These results suggest that ACNU is taken up by tumor tissue relatively rapidly and eliminated slowly, which leads to effective manifestation of its antitumor activity.

Astrocytoma↗

PubMed1981

[Comparative studies on anti-tumor effects of nitrosoureas, ACNU and MCNU, on experimental brain tumors (author's transl)].

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Animals↗

PubMed1981

[Rathke's cleft cyst -a case report (author's transl)].

A 17-year-old male was admitted to the Department of Neurosurgery, Hiroshima University Hospital because of an enlarged sella turcica which had been pointed by the skull x-ray examination performed for the facial contusion of the traffic accident. CT scan revealed an oval shaped area of hyperdensity in the center of the sella without any extrasellar extensions. After contrast administration this area showed almost no increased density. The patient had no neurological abnormalities except for hyposmia and left blindness due to the traffic accident. Endocrinological studies were normal. From these findings non-functioning intrapituitary adenoma was suspected and exploration of the sella through the transsphenoidal route was performed. When the dura mater was opened, about 1.5 microliter of white mucous colloid material was exposed. This material fully occupied the pituitary fossa and the pituitary gland was compressed upward. Histologically the cyst wall was composed of pseudostriated columnar ciliated epithelium and partially squamous metaplasia was seen. These epithelium and colloid material structure were stained by PAS-Alcian blue. The tubular gland-like structure was visible in the posterior lobe adjacent to the cyst wall. The size of Rathke's cleft cyst, its pathogenesis, its findings by CT scan and surgical aspect were discussed.

Adolescent↗

PubMed1981

Effect of intracerebral administration of Corynebacterium parvum on the growth of brain tumors in mice.

The effect of intracerebral administration of Corynebacterium parvum (C. parvum) on the growth of syngeneic brain tumors in C57BL/6 mice and the mechanism of its action were investigated. Mice were inoculated with 10(4) malignant glioma cells intracerebrally, and treated with various doses of C parvum on day 6 after tumor inoculation. The growth of tumors was significantly inhibited in proportion ot the dose of C. parvum. The cytotoxic activity of effector cells was enhanced when C. parvum was administered at the site of tumor inoculation. Significant cytotoxic activity was observed in the adherent cell fraction of brain mononuclear cells, while less cytotoxic activity was observed in the nonadherent cell fraction. These results indicate that activated intracranial macrophages may participate in the tumoricidal effect of intracerebral C. parvum administration.

Animals↗

PubMed1978

[False cortical aneurysm complicated by chronic subdural hematoma (author's transl)].

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Cerebral Cortex↗

PubMedDate not supplied

Lethal effects of the combination of hyperthermia and bromocriptine or a somatostatin analogue on normal pituitary cells and pituitary tumour cells.

Effects of hyperthermia alone and combined with bromocriptine (BC) or a somatostatin analogue (SMS 201-995) were studied in vitro on normal pituitary and pituitary tumour cells (GH3 cells). GH3 cells were more sensitive to heat than normal pituitary cells and a maximal difference in survival was obtained with hyperthermia at 42.5 degrees C for 6 h. BC had cytotoxic and antiproliferative effects on GH3 cells, whereas SMS 201-995 was not effective. Hyperthermia at 42.5 degrees C for 3 h in combination with BC enhanced selective cytotoxicity for GH3 cells. In contrast, combined treatment with hyperthermia and SMS 201-995 failed to enhance cytotoxicity for GH3 cells. The combination of hyperthermia and BC could provide improved therapeutic efficacy in patients with pituitary adenomas.

Animals↗