RADIOTHERAPY IN CANCER OF THE CERVIX.
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Biomedical subjects
Publications and source records attributed to K Kiviniitty.
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A simplified single-plane angiocardiographic method for the measurement of the left ventricular volumes in the reindeer heart has been developed, on the assumption that the left ventricle forms half a revolution ellipsoid. On the basis of a study of 30 ventricular casts the following formulae were constructed for the calculation of the left ventricular volume (VLV) in end-diastole (D) and end-systole (S): VLVD = 0.60 k3a2l - 3.9 and VVLS = 0.40 k3a2l - 12 where k = magnification factor of the x-ray system, a = cross-sectional diameter of the ventricle and 1 = longitudinal diameter of the ventricle. The method was tested on the casts by comparison with biplane integration and with the single-plane ellipsoid method. In addition to this, a comparison was made in vivo by simultaneous stroke volume determination by angiocardiography and the oxygen Fick, and a good agreement was observed.
Structural chromosome aberrations were analysed in the peripheral blood lymphocytes of 15 children, aged 1 to 13 years, before, immediately after, 24 hours after and 6 to 8 months after cardioangiographic examination. Statistically significant increases were only demonstrated in the frequency of gaps (p less than 0.05) and, consequently, in the frequency of aberrant cells (p less than 0.05) immediately after cardioangiography. Most of the chromosome damage clearly disappeared within 24 hours. In addition, whole blood cultures were exposed in vitro to low dose radiation, a contrast medium, and radiation together with the contrast medium. No statistically significant differences could be observed in the chromosome aberration frequencies. It was concluded that the modern radiographic procedure, which uses very low radiation doses and less contrast medium, does not cause a consistent, permanent increase of chromosomal damage in the lymphocytes of children. However, the situation may be different if the child undergoes many radiographic examinations or the radiation doses are high.
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